ENSMUSG00000073421


Mus musculus

Features
Gene ID: ENSMUSG00000073421
  
Biological name :H2-Ab1
  
Synonyms : H2-Ab1 / histocompatibility 2, class II antigen A, beta 1 / P14483
  
Possible biological names infered from orthology : HLA-DQB1 / HLA-DQB2 / major histocompatibility complex, class II, DQ beta 1 / major histocompatibility complex, class II, DQ beta 2 / P05538
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 34263209
Gene end: 34269418
  
Corresponding Affymetrix probe sets: 10444291 (MoGene1.0st)   1425477_x_at (Mouse Genome 430 2.0 Array)   1450648_s_at (Mouse Genome 430 2.0 Array)   1451721_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041008
NCBI entrez gene - 14961     See in Manteia.
MGI - MGI:103070
RefSeq - NM_207105
RefSeq Peptide - NP_996988
swissprot - P14483
swissprot - Q3TD53
Ensembl - ENSMUSG00000073421
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU929676.1ENSDARG00000104635Danio rerio
 FO744840.1ENSDARG00000110501Danio rerio
 mhc2bENSDARG00000104730Danio rerio
 mhc2dabENSDARG00000079105Danio rerio
 mhc2dbbENSDARG00000056330Danio rerio
 si:busm1-104n07.3ENSDARG00000074510Danio rerio
 si:busm1-228j01.4ENSDARG00000088872Danio rerio
 si:busm1-228j01.6ENSDARG00000041705Danio rerio
 si:ch73-158p21.3ENSDARG00000101030Danio rerio
 si:zfos-2070c2.3ENSDARG00000076307Danio rerio
 zgc:103700ENSDARG00000116524Danio rerio
 HLA-DQB1ENSG00000179344Homo sapiens
 P05538ENSG00000232629Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*ENSMUSG0000006058660
H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*ENSMUSG0000006734151
H2-Ob / histocompatibility 2, O region beta locus / P13765* / HLA-DOB* / major histocompatibility complex, class II, DO beta*ENSMUSG0000004153847
H2-DMb1 / histocompatibility 2, class II, locus Mb1 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*ENSMUSG0000007954725
H2-DMb2 / histocompatibility 2, class II, locus Mb2 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*ENSMUSG0000003754825


Protein motifs (from Interpro)
Interpro ID Name
 IPR000353  MHC class II, beta chain, N-terminal
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR003597  Immunoglobulin C1-set
 IPR007110  Immunoglobulin-like domain
 IPR011162  MHC classes I/II-like antigen recognition protein
 IPR013783  Immunoglobulin-like fold
 IPR014745  MHC class II, alpha/beta chain, N-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002344 B cell affinity maturation IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response ISO
 biological_processGO:0002455 humoral immune response mediated by circulating immunoglobulin ISO
 biological_processGO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II IEA
 biological_processGO:0002579 positive regulation of antigen processing and presentation IDA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IDA
 biological_processGO:0006955 immune response IMP
 biological_processGO:0019882 antigen processing and presentation IDA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
 biological_processGO:0046635 positive regulation of alpha-beta T cell activation TAS
 biological_processGO:0048002 antigen processing and presentation of peptide antigen IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005771 multivesicular body IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0042613 MHC class II protein complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0015643 toxic substance binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042605 peptide antigen binding IDA
 molecular_functionGO:1990405 protein antigen binding IPI


Pathways (from Reactome)
Pathway description
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
MHC class II antigen presentation
PD-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Ighmtm1Cgn/Ighmtm1Cgn,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Ighmtm1Cgn H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: FVB.129S7-Rock1tm1Leiw

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0000716 abnormal immune system cell morphology "anomalous structure, development, or number of immune cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0000727 absent CD4-8+ cells "lack of the set of single-positive T cells that express CD8 on their surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Doi/H2-Ab1tm1Doi,Lattm1Mal/Lattm1Mal
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Engtm1Hma/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Hma

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)1Dv/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rfx5tm1.1Ifo/Rfx5tm1.1Ifo
Genetic Background: involves: 129 * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Stc2tm1Gthi/Stc2tm1Gthi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)70Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Ighmtm1Cgn/Ighmtm1Cgn,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Ighmtm1Cgn H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)70Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Engtm1Hma/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Hma

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DRB1)31Dmz/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)1Dv/0,Tg(HLA-DRB1)31Dmz/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)70Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Jae/B2mtm1Jae,Cd4tm1.1Yzo/Cd4tm1.1Yzo
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: H2-Ab1tm1.1Jssh/H2-Ab1tm1.1Jssh
Genetic Background: C57BL/6-H2-Ab1tm1.1Jssh

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scnn1atm1Hum/Scnn1atm1Hum
Genetic Background: involves: 129/Sv

Allelic Composition: H2-Ab1tm1Hpl/H2-Ab1+
Genetic Background: involves: 129S4/SvJae

 MP:0002358 abnormal spleen periarteriolar lymphoid sheath morphology "anomalous structure of the area of the spleen in which T cells surround the central arteriole " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: March1tm1.1Sish/March1tm1.1Sish
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug
Genetic Background: involves: C57BL/6

Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DRB1)31Dmz/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)1Dv/0,Tg(HLA-DRB1)31Dmz/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: B6(C)-H2-Ab1bm12/KhEgJ

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
Genetic Background: involves: 129 * C57BL/6J

 MP:0002454 abnormal macrophage antigen presentation "impairment of these phagocytic cells to process and present antigen to T lymphocytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
Genetic Background: involves: 129 * C57BL/6J

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Rb1tm3Tyj/Rb1tm3Tyj,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0,Tg(tetO-RNAi:Trp53)ASlowe/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: B6.129S2-H2-Ab1tm1Gru

Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug
Genetic Background: involves: C57BL/6

Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0002726 abnormal pulmonary vein morphology "structrual anomaly of the veins that return oxygenated blood from the lungs to the left atrium of the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0003410 abnormal artery development "anomaly in the process of forming the blood vessels that carry blood away from the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ptstm1Ich/Ptstm1Ich,Tg(DBH-PTS)6Csic/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003504 thyroid inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the thyroid gland" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Ighmtm1Cgn/Ighmtm1Cgn,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Ighmtm1Cgn H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)70Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Doi/H2-Ab1tm1Doi,Lattm1Mal/Lattm1Mal
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tespa1tm1Lrgl/Tespa1tm1Lrgl
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug
Genetic Background: involves: C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-B2mtm1Unc H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0003901 abnormal PQ interval "anomaly in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Ighmtm1Cgn/Ighmtm1Cgn,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Ighmtm1Cgn H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: B6.129S2-H2-Ab1tm1Gru

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr3tm3.1Cxd/Fgfr3+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: H2-Ab1tm1Doi/H2-Ab1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * NOD/Lt

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)70Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0004566 myocardial fiber degeneration "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0004797 increased anti-erythrocyte antigen antibody level "elevated level of antibodies to erythrocyte antigen present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug
Genetic Background: involves: C57BL/6

Allelic Composition: H2-Ab1tm1Wug/H2-Ab1tm1Wug,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Engtm1Hma/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Hma

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)1Dv/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DRB1)31Dmz/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)1Dv/0,Tg(HLA-DRB1)31Dmz/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0004824 decreased susceptibility to experimental autoimmune myasthenia gravis "reduced likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: B6(C)-H2-Ab1bm12/KhEgJ

 MP:0004918 abnormal negative T cell selection "any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]
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Allelic Composition: Tg(TcrAND)53Hed/?,Themistm1Lov/Themistm1Lov
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1.1Jssh/H2-Ab1tm1.1Jssh
Genetic Background: C57BL/6-H2-Ab1tm1.1Jssh

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DRB1)31Dmz/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)1Dv/0,Tg(HLA-DRB1)31Dmz/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9tm3(cre)Crm/Sox9+,Sp7tm1Crm/Sp7tm2Crm
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pomctm1Low/Pomctm1Low,Tg(Pomc)#Low/Tg(Pomc)#Low
Genetic Background: involves: 129 * C57BL/6 * CBA * DBA/2 * Swiss Webster

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: B6(C)-H2-Ab1bm12/KhEgJ

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: B6(C)-H2-Ab1bm12/KhEgJ

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Ighmtm1Cgn/Ighmtm1Cgn,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Ighmtm1Cgn H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: B6(C)-H2-Ab1bm12/KhEgJ

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0005355 enlarged thyroid gland "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85158, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Ighmtm1Cgn/Ighmtm1Cgn,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Ighmtm1Cgn H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Engtm1Hma/Eng+
Genetic Background: 129P2/OlaHsd-Engtm1Hma

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)1Dv/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Rag1tm1Mom/Rag1tm1Mom,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-Rag1tm1Mom H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0006085 myocardial necrosis "pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)70Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl

 MP:0006120 mitral valve prolapse "collapse of one or more of the mitral valve cusps backward allowing blood to leak backwards, ususally the result of enlargement of one or more of the valve cusps" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Runx1tm1Toku/Runx1tm1Toku,Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: H2-Ab1tm1Koni/H2-Ab1tm1.1Koni,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Cd8b1tm1Litt/Cd8b1tm1Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129 * FVB/N

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: B6.129S2-H2-Ab1tm1Gru

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Allelic Composition: H2-Ab1em1Ygch/H2-Ab1em1Ygch
Genetic Background: NOD/ShiLtJ-H2-Ab1em1Ygch

Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
Genetic Background: involves: 129 * C57BL/6J

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Cd8atm1Asin/Cd8atm1Asin,Cd8b1tm1Litt/Cd8b1tm1Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cd4tm3.2Litt/Cd4tm3.2Litt,H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1bm12/H2-Ab1bm12
Genetic Background: NZB.B6(C)-H2-Ab1bm12

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tespa1tm1Lrgl/Tespa1tm1Lrgl
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008397 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology "any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: H2-Ab1tm1Koni/H2-Ab1tm1.1Koni,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Runx1tm1Toku/Runx1tm1Toku,Runx3tm1Itan/Runx3tm1Itan,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: March1tm1.1Sish/March1tm1.1Sish
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)1Dv/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: March1tm1.1Sish/March1tm1.1Sish
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)1Dv/0,Tg(Ins2-CD80)3B7Flv/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA

 MP:0008828 abnormal lymph node cell ratio "deviation from the standard ratios of lymph node cell subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Pax6Sey/Pax6Sey
Genetic Background: involves: Swiss

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tsc1tm1Chdl/Tsc1tm1Chdl
Genetic Background: B6NHsd.129P2-Tsc1tm1Chdl

Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Doi/H2-Ab1tm1Doi
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number "a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: H2-Ab1tm1Koni/H2-Ab1tm1.1Koni,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J

 MP:0010334 pleural effusion "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(HLA-DQA1,HLA-DQB1)73Myl/0
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

Allelic Composition: B2mtm1Unc/B2mtm1Unc,H2-Ab1tm1Gru/H2-Ab1tm1Gru,Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
Genetic Background: NOD.Cg-B2mtm1Unc H2-Ab1tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell

 MP:0010539 decreased level of surface class II molecules "reduction in the concentration of major histocompatibility complex class II molecules expressed at the cell surface" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
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Allelic Composition: H2-Ab1tm1Koni/H2-Ab1tm1.1Koni,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: H2-Ab1tm1Koni/H2-Ab1tm1.1Koni,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129X1/SvJ * C3H * C57BL/6 * C57BL/6J

 MP:0012765 decreased alpha-beta T cell number "reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]
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Allelic Composition: H2-Ab1em1Dvs/H2-Ab1em1Dvs,H2-D1em5Dvs/H2-D1em5Dvs,H2-K1em1Dvs/H2-K1em1Dvs
Genetic Background: NOD/ShiLtDvs-H2-K1em1Dvs H2-Ab1em1Dvs H2-D1em5Dvs/Dvs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001052 Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*  / reaction / complex
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex / reaction
 ENSMUSG00000003033 Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*  / complex
 ENSMUSG00000003309 Ap1m2 / adaptor related protein complex 1 mu 2 subunit / Q9Y6Q5*  / complex
 ENSMUSG00000002033 Cd3g / P11942 / T-cell surface glycoprotein CD3 gamma chain / P09693* / CD3g molecule*  / complex
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSMUSG00000005763 Cd247 / P24161 / T-cell surface glycoprotein CD3 zeta chain / P20963* / CD247 molecule*  / complex
 ENSMUSG00000009090 Ap1b1 / O35643 / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA. / Q10567* / adaptor related protein complex 1 beta 1 subunit*  / complex
 ENSMUSG00000004266 Ptpn6 / P29351 / protein tyrosine phosphatase, non-receptor type 6 / P29350*  / reaction
 ENSMUSG00000020386 Sar1b / Q9CQC9 / secretion associated Ras related GTPase 1B / Q9Y6B6*  / reaction / complex
 ENSMUSG00000020368 Canx / P35564 / Calnexin / P27824*  / reaction / complex
 ENSMUSG00000038642 Ctss / O70370 / cathepsin S / P25774*  / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / complex / reaction
 ENSMUSG00000021190 Lgmn / O89017 / legumain / Q99538*  / reaction
 ENSMUSG00000020986 Q01405 / Sec23a / Protein transport protein Sec23A / Q15436* / Sec23 homolog A, coat complex II component*  / reaction / complex
 ENSMUSG00000026117 Zap70 / P43404 / zeta-chain (TCR) associated protein kinase / P43403* / zeta chain of T cell receptor associated protein kinase 70*  / reaction / complex
 ENSMUSG00000027843 P29352 / Ptpn22 / Tyrosine-protein phosphatase non-receptor type 22 / Q9Y2R2* / protein tyrosine phosphatase, non-receptor type 22*  / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex / reaction
 ENSMUSG00000031731 Ap1g1 / P22892 / AP-1 complex subunit gamma-1 / O43747* / adaptor related protein complex 1 gamma 1 subunit*  / complex
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / reaction
 ENSMUSG00000031367 Ap1s2 / Q9DB50 / AP-1 complex subunit sigma-2 / P56377* / adaptor related protein complex 1 sigma 2 subunit*  / complex
 ENSMUSG00000032094 Cd3d / P04235 / T-cell surface glycoprotein CD3 delta chain / P04234* / CD3d molecule*  / complex
 ENSMUSG00000030298 Sec13 / Q9D1M0 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735*  / reaction / complex
 ENSMUSG00000041538 H2-Ob / histocompatibility 2, O region beta locus / P13765* / HLA-DOB* / major histocompatibility complex, class II, DO beta*  / complex / reaction
 ENSMUSG00000000409 Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction
 ENSMUSG00000035325 Q3UPL0 / Sec31a / Protein transport protein Sec31A / O94979* / SEC31 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction
 ENSMUSG00000036391 Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*  / complex / reaction
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / reaction / complex
 ENSMUSG00000023274 Cd4 / P06332 / T-cell surface glycoprotein CD4 / P01730* / CD4 molecule*  / complex
 ENSMUSG00000032093 Cd3e / P22646 / T-cell surface glycoprotein CD3 epsilon chain / P07766* / CD3e molecule*  / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000030124 Lag3 / Q61790 / Lymphocyte activation 3 protein / P18627* / lymphocyte activating 3*  / complex / reaction
 ENSMUSG00000037548 H2-DMb2 / histocompatibility 2, class II, locus Mb2 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*  / reaction / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction / complex
 ENSMUSG00000079547 H2-DMb1 / histocompatibility 2, class II, locus Mb1 / P28068* / HLA-DMB* / AL645941.2* / major histocompatibility complex, class II, DM beta*  / complex / reaction
 ENSMUSG00000037649 H2-DMa / histocompatibility 2, class II, locus DMa / P28067* / HLA-DMA* / major histocompatibility complex, class II, DM alpha*  / complex / reaction
 ENSMUSG00000024334 H2-Oa / major histocompatibility complex, class II, DO alpha / P06340* / HLA-DOA*  / reaction / complex
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / complex / reaction
 ENSMUSG00000039234 Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*  / complex / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / reaction / complex
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction
 ENSMUSG00000025314 Ptprj / protein tyrosine phosphatase, receptor type J / Q12913*  / reaction
 ENSMUSG00000004849 Ap1s1 / P61967 / AP-1 complex subunit sigma-1A / P61966* / adaptor related protein complex 1 sigma 1 subunit*  / complex
 ENSMUSG00000054702 Ap1s3 / Q7TN05 / AP-1 complex subunit sigma-3 / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*  / complex






 

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