ENSMUSG00000031367


Mus musculus

Features
Gene ID: ENSMUSG00000031367
  
Biological name :Ap1s2
  
Synonyms : AP-1 complex subunit sigma-2 / Ap1s2 / Q9DB50
  
Possible biological names infered from orthology : adaptor related protein complex 1 sigma 2 subunit / P56377
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F5
Gene start: 163909017
Gene end: 163933666
  
Corresponding Affymetrix probe sets: 10603051 (MoGene1.0st)   1437998_at (Mouse Genome 430 2.0 Array)   1447903_x_at (Mouse Genome 430 2.0 Array)   1452657_at (Mouse Genome 430 2.0 Array)   1456252_x_at (Mouse Genome 430 2.0 Array)   1460036_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033734
Ensembl peptide - ENSMUSP00000066185
Ensembl peptide - ENSMUSP00000107913
Ensembl peptide - ENSMUSP00000114902
NCBI entrez gene - 108012     See in Manteia.
MGI - MGI:1889383
RefSeq - XM_011247769
RefSeq - NM_001290378
RefSeq - NM_001290379
RefSeq - NM_026887
RefSeq - XM_006528678
RefSeq Peptide - NP_081163
RefSeq Peptide - NP_001277308
RefSeq Peptide - NP_001277307
swissprot - B1B0F6
swissprot - Q8BW87
swissprot - Q3TIV9
swissprot - Q9DB50
Ensembl - ENSMUSG00000031367
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AP1S2ENSDARG00000113225Danio rerio
 AP1S2ENSGALG00000016551Gallus gallus
 AP1S2ENSG00000182287Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ap1s1 / P61967 / AP-1 complex subunit sigma-1A / P61966* / adaptor related protein complex 1 sigma 1 subunit*ENSMUSG0000000484980
Ap1s3 / Q7TN05 / AP-1 complex subunit sigma-3 / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*ENSMUSG0000005470268
Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*ENSMUSG0000000803641
Ap4s1 / Q9WVL1 / AP-4 complex subunit sigma-1 / Q9Y587* / adaptor related protein complex 4 sigma 1 subunit*ENSMUSG0000002095533


Protein motifs (from Interpro)
Interpro ID Name
 IPR000804  Clathrin adaptor complex, small chain
 IPR011012  Longin-like domain superfamily
 IPR016635  Adaptor protein complex, sigma subunit
 IPR022775  AP complex, mu/sigma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0036465 synaptic vesicle recycling IMP
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0060612 adipose tissue development IMP
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008565 protein transporter activity IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Ap1s2tm1Pschu/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0003107 abnormal response to novelty "alteration in amount of exploration/investigation of a novel object, situation or environment" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0004793 abnormal synaptic vesicle clustering "any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

 MP:0006320 abnormal interscapular fat pad "any structural anomaly of the encapsulated adipose tissue located between the scapulae" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Ap1s2tm1Pschu/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Ap1s2tm1Pschu/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Ap1s2tm1Pschu/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Ap1s2tm1Pschu/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Ap1s2tm1Pschu/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Ap1s2tm1Pschu/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011174 lipodystrophy "abnormal or degenerative conditions of the body s adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized" [MGI:csmith]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

Allelic Composition: Ap1s2tm1Pschu/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Vangl2Lp/Vangl2+
Genetic Background: involves: 129 * LPT/LeJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003033 Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*  / complex
 ENSMUSG00000003309 Ap1m2 / adaptor related protein complex 1 mu 2 subunit / Q9Y6Q5*  / complex
 ENSMUSG00000009090 Ap1b1 / O35643 / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA. / Q10567* / adaptor related protein complex 1 beta 1 subunit*  / complex
 ENSMUSG00000019785 Clvs2 / Q8BG92 / Clavesin-2 / Q5SYC1*  / complex
 ENSMUSG00000031731 Ap1g1 / P22892 / AP-1 complex subunit gamma-1 / O43747* / adaptor related protein complex 1 gamma 1 subunit*  / complex
 ENSMUSG00000041216 Clvs1 / Q9D4C9 / Clavesin-1 / Q8IUQ0*  / complex
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex






 

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