ENSMUSG00000003309


Mus musculus

Features
Gene ID: ENSMUSG00000003309
  
Biological name :Ap1m2
  
Synonyms : adaptor related protein complex 1 mu 2 subunit / Ap1m2
  
Possible biological names infered from orthology : Q9Y6Q5
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A3
Gene start: 21294275
Gene end: 21312337
  
Corresponding Affymetrix probe sets: 10591522 (MoGene1.0st)   1460190_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003397
Ensembl peptide - ENSMUSP00000150667
Ensembl peptide - ENSMUSP00000149196
Ensembl peptide - ENSMUSP00000111093
NCBI entrez gene - 11768     See in Manteia.
MGI - MGI:1336974
RefSeq - XM_006509950
RefSeq - NM_001110300
RefSeq - NM_009678
RefSeq - XM_006509949
RefSeq Peptide - NP_033808
RefSeq Peptide - NP_001103770
swissprot - A0A1L1SUA0
swissprot - A0A0R4J1L4
swissprot - A0A0R4IZX6
swissprot - A0A1L1SQU9
Ensembl - ENSMUSG00000003309
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap1m2ENSDARG00000096454Danio rerio
 LO018011.1ENSDARG00000113932Danio rerio
 AP1M2ENSG00000129354Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*ENSMUSG0000000303379
Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*ENSMUSG0000002284141
Ap3m1 / Q9JKC8 / AP-3 complex subunit mu-1 / Q9Y2T2* / adaptor related protein complex 3 mu 1 subunit*ENSMUSG0000002182428
Ap3m2 / Q8R2R9 / AP-3 complex subunit mu-2 / P53677* / adaptor related protein complex 3 mu 2 subunit*ENSMUSG0000003153928
Ap4m1 / Q9JKC7 / AP-4 complex subunit mu-1 / O00189* / adaptor related protein complex 4 mu 1 subunit*ENSMUSG0000001951828


Protein motifs (from Interpro)
Interpro ID Name
 IPR001392  Clathrin adaptor, mu subunit
 IPR011012  Longin-like domain superfamily
 IPR018240  Clathrin adaptor, mu subunit, conserved site
 IPR022775  AP complex, mu/sigma subunit
 IPR028565  Mu homology domain
 IPR036168  AP-2 complex subunit mu, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008012 duodenal polyps "development of numerous growths that are connected to and protrude from the mucous membrane of the duodenum" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0008109 abnormal small intestinal microvillus morphology "any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0010157 abnormal small intestinal crypt cell proliferation "anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division" [MGI:jbubier "Jason Bubier, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011882 enlarged duodenum "increased size of the portion of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Colin_McKerlie]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0013482 abnormal duodenum crypts of Lieberkuhn morphology "any structural anomaly of the intestinal crypts located in the mucosa of the duodenum, the first division of the small intestine that extends from the pyloris to the junction with the jejunum" [MGI:Anna]
Show

Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0013483 abnormal jejunum crypts of Lieberkuhn morphology "any structural anomaly of the intestinal crypts located in the mucosa of the jejunum, the portion of the small intestine that extends from the duodenum to the ileum" [MGI:Anna]
Show

Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0014082 decreased small intestinal villus height "decreased height of the tiny hair-like projections which protrude from the inside of the small intestine and contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; usually accompanied by crypt elongation or hyperplasia" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004849 Ap1s1 / P61967 / AP-1 complex subunit sigma-1A / P61966* / adaptor related protein complex 1 sigma 1 subunit*  / complex
 ENSMUSG00000031731 Ap1g1 / P22892 / AP-1 complex subunit gamma-1 / O43747* / adaptor related protein complex 1 gamma 1 subunit*  / complex
 ENSMUSG00000031367 Ap1s2 / Q9DB50 / AP-1 complex subunit sigma-2 / P56377* / adaptor related protein complex 1 sigma 2 subunit*  / complex
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction
 ENSMUSG00000009090 Ap1b1 / O35643 / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA. / Q10567* / adaptor related protein complex 1 beta 1 subunit*  / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / complex
 ENSMUSG00000054702 Ap1s3 / Q7TN05 / AP-1 complex subunit sigma-3 / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*  / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000019785 Clvs2 / Q8BG92 / Clavesin-2 / Q5SYC1*  / complex
 ENSMUSG00000041216 Clvs1 / Q9D4C9 / Clavesin-1 / Q8IUQ0*  / complex






 

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