ENSMUSG00000031539


Mus musculus

Features
Gene ID: ENSMUSG00000031539
  
Biological name :Ap3m2
  
Synonyms : AP-3 complex subunit mu-2 / Ap3m2 / Q8R2R9
  
Possible biological names infered from orthology : adaptor related protein complex 3 mu 2 subunit / P53677
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 22787354
Gene end: 22805622
  
Corresponding Affymetrix probe sets: 10577586 (MoGene1.0st)   1417527_at (Mouse Genome 430 2.0 Array)   1432125_at (Mouse Genome 430 2.0 Array)   1447524_at (Mouse Genome 430 2.0 Array)   1448751_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128446
Ensembl peptide - ENSMUSP00000147967
NCBI entrez gene - 64933     See in Manteia.
MGI - MGI:1929214
RefSeq - NM_001122820
RefSeq - NM_029505
RefSeq Peptide - NP_001116292
RefSeq Peptide - NP_083781
swissprot - Q8R2R9
Ensembl - ENSMUSG00000031539
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap3m2ENSDARG00000016128Danio rerio
 AP3M2ENSGALG00000038155Gallus gallus
 AP3M2ENSG00000070718Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ap3m1 / Q9JKC8 / AP-3 complex subunit mu-1 / Q9Y2T2* / adaptor related protein complex 3 mu 1 subunit*ENSMUSG0000002182484
Ap1m2 / adaptor related protein complex 1 mu 2 subunit / Q9Y6Q5*ENSMUSG0000000330929
Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*ENSMUSG0000000303328
Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*ENSMUSG0000002284126
Ap4m1 / Q9JKC7 / AP-4 complex subunit mu-1 / O00189* / adaptor related protein complex 4 mu 1 subunit*ENSMUSG0000001951824


Protein motifs (from Interpro)
Interpro ID Name
 IPR001392  Clathrin adaptor, mu subunit
 IPR011012  Longin-like domain superfamily
 IPR018240  Clathrin adaptor, mu subunit, conserved site
 IPR022775  AP complex, mu/sigma subunit
 IPR028565  Mu homology domain
 IPR036168  AP-2 complex subunit mu, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0008089 anterograde axonal transport IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0048490 anterograde synaptic vesicle transport IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:1904115 axon cytoplasm IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0000948 nonconvulsive seizures "seizures without uncontrolled motor activity, but with impairment of consciousness" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0001499 kindling "long-lasting epileptogenic changes induced by daily sub threshold electrical brain stimulation, induced model for epilepsy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45446]
Show

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0003990 decreased neurotransmitter release "reduced secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mettm3Kln/Mettm3Kln
Genetic Background: involves: 129/Sv * C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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