ENSMUSG00000019518


Mus musculus

Features
Gene ID: ENSMUSG00000019518
  
Biological name :Ap4m1
  
Synonyms : AP-4 complex subunit mu-1 / Ap4m1 / Q9JKC7
  
Possible biological names infered from orthology : adaptor related protein complex 4 mu 1 subunit / O00189
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 138172002
Gene end: 138180429
  
Corresponding Affymetrix probe sets: 10526754 (MoGene1.0st)   1418846_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019662
Ensembl peptide - ENSMUSP00000123770
Ensembl peptide - ENSMUSP00000121338
NCBI entrez gene - 11781     See in Manteia.
MGI - MGI:1337063
RefSeq - NM_021392
RefSeq - XM_006504551
RefSeq Peptide - NP_067367
swissprot - E9Q9U6
swissprot - Q9JKC7
swissprot - E9Q416
Ensembl - ENSMUSG00000019518
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap4m1ENSDARG00000056871Danio rerio
 AP4M1ENSG00000221838Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*ENSMUSG0000002284128
Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*ENSMUSG0000000303327
Ap1m2 / adaptor related protein complex 1 mu 2 subunit / Q9Y6Q5*ENSMUSG0000000330927
Ap3m1 / Q9JKC8 / AP-3 complex subunit mu-1 / Q9Y2T2* / adaptor related protein complex 3 mu 1 subunit*ENSMUSG0000002182422
Ap3m2 / Q8R2R9 / AP-3 complex subunit mu-2 / P53677* / adaptor related protein complex 3 mu 2 subunit*ENSMUSG0000003153922


Protein motifs (from Interpro)
Interpro ID Name
 IPR001392  Clathrin adaptor, mu subunit
 IPR011012  Longin-like domain superfamily
 IPR018240  Clathrin adaptor, mu subunit, conserved site
 IPR022775  AP complex, mu/sigma subunit
 IPR028565  Mu homology domain
 IPR036168  AP-2 complex subunit mu, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0006622 protein targeting to lysosome IEA
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0006895 Golgi to endosome transport IEA
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0090160 Golgi to lysosome transport IEA
 biological_processGO:1903361 protein localization to basolateral plasma membrane ISS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030124 AP-4 adaptor complex IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Lysosome Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ap4e1tm1b(KOMP)Wtsi/Ap4e1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1b(KOMP)Wtsi/Orl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001998 Ap4e1 / Q80V94 / AP-4 complex subunit epsilon-1 / Q9UPM8* / adaptor related protein complex 4 epsilon 1 subunit*  / complex
 ENSMUSG00000022892 App / P12023 / amyloid beta (A4) precursor protein / P05067* / amyloid beta precursor protein*  / reaction / complex
 ENSMUSG00000020955 Ap4s1 / Q9WVL1 / AP-4 complex subunit sigma-1 / Q9Y587* / adaptor related protein complex 4 sigma 1 subunit*  / complex
 ENSMUSG00000032952 Ap4b1 / Q9WV76 / AP-4 complex subunit beta-1 / Q9Y6B7* / adaptor related protein complex 4 beta 1 subunit*  / complex






 

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