ENSMUSG00000032952


Mus musculus

Features
Gene ID: ENSMUSG00000032952
  
Biological name :Ap4b1
  
Synonyms : Ap4b1 / AP-4 complex subunit beta-1 / Q9WV76
  
Possible biological names infered from orthology : adaptor related protein complex 4 beta 1 subunit / Q9Y6B7
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 103809520
Gene end: 103822025
  
Corresponding Affymetrix probe sets: 10494957 (MoGene1.0st)   1416631_at (Mouse Genome 430 2.0 Array)   1421726_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000075904
Ensembl peptide - ENSMUSP00000143355
Ensembl peptide - ENSMUSP00000142457
Ensembl peptide - ENSMUSP00000102437
Ensembl peptide - ENSMUSP00000102436
Ensembl peptide - ENSMUSP00000044262
NCBI entrez gene - 67489     See in Manteia.
MGI - MGI:1337130
RefSeq - XM_006501933
RefSeq - NM_001163552
RefSeq - NM_001163553
RefSeq - NM_026193
RefSeq - XM_006501932
RefSeq Peptide - NP_001157025
RefSeq Peptide - NP_001157024
RefSeq Peptide - NP_080469
swissprot - A0A0G2JDQ2
swissprot - B0V3P3
swissprot - A0A0G2JFY6
swissprot - B0V3P4
swissprot - Q9WV76
Ensembl - ENSMUSG00000032952
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap4b1ENSDARG00000013726Danio rerio
 AP4B1ENSGALG00000035295Gallus gallus
 AP4B1ENSG00000134262Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm43064 / AP4B1* / Q9Y6B7* / adaptor related protein complex 4 beta 1 subunit*ENSMUSG0000010505390
Ap1b1 / O35643 / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA. / Q10567* / adaptor related protein complex 1 beta 1 subunit*ENSMUSG0000000909027
Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*ENSMUSG0000003515227


Protein motifs (from Interpro)
Interpro ID Name
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR011989  Armadillo-like helical
 IPR015151  Beta-adaptin appendage, C-terminal subdomain
 IPR016024  Armadillo-type fold
 IPR016342  AP-1/2/4 complex subunit beta
 IPR026739  AP complex subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IMP
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0061938 protein localization to somatodendritic compartment IMP
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network TAS
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019898 extrinsic component of membrane ISO
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030124 AP-4 adaptor complex ISO
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030276 clathrin binding IEA


Pathways (from Reactome)
Pathway description
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ildr2Dbsm1-DBA/2J/Ildr2Dbsm1-DBA/2J
Genetic Background: B6.D2-Ildr2Dbsm1-DBA/2J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ildr2Dbsm1-DBA/2J/Ildr2Dbsm1-DBA/2J
Genetic Background: B6.D2-Ildr2Dbsm1-DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001998 Ap4e1 / Q80V94 / AP-4 complex subunit epsilon-1 / Q9UPM8* / adaptor related protein complex 4 epsilon 1 subunit*  / complex
 ENSMUSG00000022892 App / P12023 / amyloid beta (A4) precursor protein / P05067* / amyloid beta precursor protein*  / reaction / complex
 ENSMUSG00000019518 Ap4m1 / Q9JKC7 / AP-4 complex subunit mu-1 / O00189* / adaptor related protein complex 4 mu 1 subunit*  / complex
 ENSMUSG00000020955 Ap4s1 / Q9WVL1 / AP-4 complex subunit sigma-1 / Q9Y587* / adaptor related protein complex 4 sigma 1 subunit*  / complex






 

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