ENSMUSG00000022892


Mus musculus

Features
Gene ID: ENSMUSG00000022892
  
Biological name :App
  
Synonyms : amyloid beta (A4) precursor protein / App / P12023
  
Possible biological names infered from orthology : amyloid beta precursor protein / P05067
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.3
Gene start: 84949685
Gene end: 85173766
  
Corresponding Affymetrix probe sets: 10440491 (MoGene1.0st)   1420621_a_at (Mouse Genome 430 2.0 Array)   1427442_a_at (Mouse Genome 430 2.0 Array)   1438373_at (Mouse Genome 430 2.0 Array)   1438374_x_at (Mouse Genome 430 2.0 Array)   1440153_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005406
Ensembl peptide - ENSMUSP00000153907
Ensembl peptide - ENSMUSP00000154061
Ensembl peptide - ENSMUSP00000154097
Ensembl peptide - ENSMUSP00000154389
Ensembl peptide - ENSMUSP00000154401
NCBI entrez gene - 11820     See in Manteia.
MGI - MGI:88059
RefSeq - XM_006522874
RefSeq - NM_001198823
RefSeq - NM_001198824
RefSeq - NM_001198825
RefSeq - NM_001198826
RefSeq - NM_007471
RefSeq - XM_006522873
RefSeq Peptide - NP_001185754
RefSeq Peptide - NP_001185755
RefSeq Peptide - NP_031497
RefSeq Peptide - NP_001185752
RefSeq Peptide - NP_001185753
swissprot - Q6GR78
swissprot - P12023
swissprot - Q3TWF3
Ensembl - ENSMUSG00000022892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 appaENSDARG00000104279Danio rerio
 APPENSGALG00000015770Gallus gallus
 APPENSG00000142192Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aplp2 / Q06335 / Amyloid-like protein 2 / Q06481* / amyloid beta precursor like protein 2*ENSMUSG0000003199649
Aplp1 / amyloid beta precursor like protein 1 / P51693*ENSMUSG0000000665133


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008154  Amyloidogenic glycoprotein, extracellular
 IPR008155  Amyloidogenic glycoprotein
 IPR011178  Amyloidogenic glycoprotein, copper-binding
 IPR013803  Amyloidogenic glycoprotein, amyloid-beta peptide
 IPR015849  Amyloidogenic glycoprotein, heparin-binding
 IPR019543  Beta-amyloid precursor protein C-terminal
 IPR019744  Amyloidogenic glycoprotein, extracellular domain conserved site
 IPR019745  Amyloidogenic glycoprotein, intracellular domain, conserved site
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR024329  Amyloidogenic glycoprotein, E2 domain
 IPR028866  Amyloid beta A4 protein
 IPR036176  E2 domain superfamily
 IPR036454  Amyloidogenic glycoprotein, heparin-binding domain superfamily
 IPR036669  Amyloidogenic glycoprotein, copper-binding domain superfamily
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily
 IPR037071  Amyloidogenic glycoprotein, amyloid-beta peptide superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001967 suckling behavior IGI
 biological_processGO:0002265 astrocyte activation involved in immune response IEA
 biological_processGO:0006378 mRNA polyadenylation IDA
 biological_processGO:0006417 regulation of translation IDA
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0006878 cellular copper ion homeostasis IMP
 biological_processGO:0006897 endocytosis IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006979 response to oxidative stress IGI
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007176 regulation of epidermal growth factor-activated receptor activity IGI
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007613 memory TAS
 biological_processGO:0007617 mating behavior IGI
 biological_processGO:0007626 locomotory behavior IGI
 biological_processGO:0008088 axo-dendritic transport IMP
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0009987 cellular process IEA
 biological_processGO:0010288 response to lead ion IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0014005 microglia development IEA
 biological_processGO:0016199 axon midline choice point recognition IMP
 biological_processGO:0016322 neuron remodeling IMP
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0030198 extracellular matrix organization IGI
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031175 neuron projection development IDA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032640 tumor necrosis factor production IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IMP
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043393 regulation of protein binding IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IGI
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048143 astrocyte activation IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048669 collateral sprouting in absence of injury IGI
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050803 regulation of synapse structure or activity IMP
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0050885 neuromuscular process controlling balance IGI
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051124 synaptic growth at neuromuscular junction IGI
 biological_processGO:0051247 positive regulation of protein metabolic process IEA
 biological_processGO:0051260 protein homooligomerization ISO
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051563 smooth endoplasmic reticulum calcium ion homeostasis IGI
 biological_processGO:0060291 long-term synaptic potentiation TAS
 biological_processGO:0061890 positive regulation of astrocyte activation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071874 cellular response to norepinephrine stimulus IEA
 biological_processGO:0090647 modulation of age-related behavioral decline IEA
 biological_processGO:0098815 modulation of excitatory postsynaptic potential IEA
 biological_processGO:0150003 regulation of spontaneous synaptic transmission IEA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1903980 positive regulation of microglial cell activation IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1905908 positive regulation of amyloid fibril formation IEA
 biological_processGO:1990000 amyloid fibril formation IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990535 neuron projection maintenance IEA
 biological_processGO:2000406 positive regulation of T cell migration IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005641 nuclear envelope lumen IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0035253 ciliary rootlet IDA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0044304 main axon IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0051233 spindle midzone IDA
 cellular_componentGO:0097449 astrocyte projection IEA
 cellular_componentGO:1990761 growth cone lamellipodium IEA
 cellular_componentGO:1990812 growth cone filopodium IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046914 transition metal ion binding IEA
 molecular_functionGO:0051425 PTB domain binding IEA
 molecular_functionGO:0070851 growth factor receptor binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
RIP-mediated NFkB activation via ZBP1
ECM proteoglycans
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
G alpha (i) signalling events
Lysosome Vesicle Biogenesis
Formyl peptide receptors bind formyl peptides and many other ligands
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Advanced glycosylation endproduct receptor signaling
Post-translational protein phosphorylation
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm3.1Tcs/Apptm3.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Atmintm1.1Axbe/Atmintm1.1Axbe
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Npc1m1N/Npc1m1N
Genetic Background: C.Cg-Apptm1Dbo Npc1m1N

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: B6.129S2-Apptm1Cwe

Allelic Composition: Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1Ini/App+
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apptm1Dbo/App+,Dab1tm1Bwh/Dab1tm1Bwh
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Npc1m1N/Npc1m1N
Genetic Background: C.Cg-Apptm1Dbo Npc1m1N

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Npc1m1N/Npc1m1N
Genetic Background: C.Cg-Apptm1Dbo Npc1m1N

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Prkar1atm1Gsm/Prkar1atm1Gsm
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Apptm1Ck/Apptm1Ck,Tg(PDGFB-PSEN1)1Jhd/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Chattm2(cre)Lowl/Chat+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm2.1Zhe/Apptm2.1Zhe
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1Dbo/Apptm3.1Zhe
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm3.1Zhe/Apptm3.1Zhe
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Apptm1Dbo/Apptm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm

Allelic Composition: Apptm3.2Umu/Apptm2Cwe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Npc1m1N/Npc1m1N
Genetic Background: C.Cg-Apptm1Dbo Npc1m1N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Apptm3.1Zhe/Apptm3.1Zhe,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Apptm1Ck/Apptm1Ck
Genetic Background: involves: 129

Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apptm1Ini/App+
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Apptm1Ini/App+
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm

Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Npc1m1N/Npc1m1N
Genetic Background: C.Cg-Apptm1Dbo Npc1m1N

 MP:0001411 spinning "compulsive rolling of the body" [J:17123]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Apptm1Ini/App+
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Apptm1Ini/App+
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm3.1Tcs/Apptm3.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002065 abnormal fear/anxiety-related behavior "altered response in tests for fear or anxiety related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apptm2Umu/Apptm2Umu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apptm1Ini/App+
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Apptm1Dbo/Apptm1Dbo,Npc1m1N/Npc1m1N
Genetic Background: C.Cg-Apptm1Dbo Npc1m1N

Allelic Composition: Apptm1Dbo/App+,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apptm1Dbo/Apptm1Dbo,Lrp4tm1Her/Lrp4+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

Allelic Composition: Apptm1Ck/Apptm1Ck
Genetic Background: involves: 129

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoa1tm1Bres/Apoa1tm1Bres,Apoa2tm1Bres/Apoa2tm1Bres
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apptm3.1Umu/Apptm3.1Umu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Apptm2.1Zhe/Apptm2.1Zhe
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apptm3.1Zhe/Apptm3.1Zhe
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: 129S-Apptm1Cwe

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: B6.129S2-Apptm1Cwe

Allelic Composition: Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apptm2Umu/Apptm2Umu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apptm3.2Umu/Apptm2Cwe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: 129S-Apptm1Cwe

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: 129S-Apptm1Cwe

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: B6.129S2-Apptm1Cwe

Allelic Composition: Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apptm2Umu/Apptm2Umu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002798 abnormal active avoidance behavior "defects in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Apptm1Ini/App+
Genetic Background: involves: C57BL/6 * CBA * CD-1

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0003062 abnormal coping response "altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli" [RGD:Rat Genome Database submission]
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Allelic Composition: Ap4e1tm1b(KOMP)Wtsi/Ap4e1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1b(KOMP)Wtsi/Orl

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Apptm1Ini/App+
Genetic Background: involves: C57BL/6 * CBA * CD-1

Allelic Composition: Apptm1.1Cep/Apptm1.1Cep,Psen1tm1Dgf/Psen1tm1Dgf
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Apptm1Ck/Apptm1Ck,Tg(PDGFB-PSEN1M146L)2Jhd/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

Allelic Composition: Apptm3.1Zhe/Apptm3.1Zhe,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav

Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm3.1Tcs/Apptm3.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Apptm1Dbo/Apptm1Dbo,Npc1m1N/Npc1m1N
Genetic Background: C.Cg-Apptm1Dbo Npc1m1N

Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm3.1Tcs/Apptm3.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003459 increased fear-related response "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm

 MP:0004250 tau protein deposits "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Atmintm1.1Axbe/Atmintm1.1Axbe
Genetic Background: involves: BALB/c * C57BL/6

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ap4e1tm1b(KOMP)Wtsi/Ap4e1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1b(KOMP)Wtsi/Orl

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Xpctm1Ecf/Xpctm1Ecf
Genetic Background: involves: 129

Allelic Composition: Apptm1Cep/App+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apptm1.1Cep/Apptm1.1Cep
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Apptm1.1Cep/App+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005635 decreased circulating bilirubin level "less thant the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ap4e1tm1b(KOMP)Wtsi/Ap4e1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1b(KOMP)Wtsi/Orl

 MP:0008222 decreased hippocampal commissure size "reduced size of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: 129S-Apptm1Cwe

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: B6.129S2-Apptm1Cwe

Allelic Composition: Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: 129S-Apptm1Cwe

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: B6.129S2-Apptm1Cwe

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

 MP:0008817 hematoma "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm3.1Tcs/Apptm3.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs,Casttm1Tcs/Casttm1Tcs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmintm1.1Axbe/Atmintm1.1Axbe
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmintm1.1Axbe/Atmintm1.1Axbe
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm
Genetic Background: involves: 129 * 129S1/Sv * 129X1/SvJ

Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0
Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Apptm2.1Tcs/Apptm2.1Tcs
Genetic Background: involves: C57BL/6

Allelic Composition: Apptm3.1Tcs/Apptm3.1Tcs
Genetic Background: involves: C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Apptm1Somm/Apptm1Somm
Genetic Background: C57BL/6-Apptm1Somm

Allelic Composition: Apptm3.2Umu/Apptm2Cwe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0010162 increased brain cholesterol level "greater than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Npc1m1N/Npc1m1N
Genetic Background: C.Cg-Apptm1Dbo Npc1m1N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm2.1Zhe/Apptm2.1Zhe
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm2.1Zhe
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1Dbo/Apptm1Dbo
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1Dbo/Apptm3.1Zhe
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm3.1Zhe/Apptm3.1Zhe
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Apptm1Dbo/Apptm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0012065 increased astrocyte number "increase in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord" [CL:0000127, MGI:csmith]
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Allelic Composition: Apptm1Ck/Apptm1Ck,Tg(PDGFB-PSEN1M146L)2Jhd/0
Genetic Background: involves: 129 * Black Swiss * C57BL/6 * DBA/2 * SW

 MP:0020408 altered susceptibility to induced thrombosis "any anomaly in the formation of thrombi following mechanical or chemical stimulation of thrombosis" [PMID:16614756, PMID:9262402]
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Allelic Composition: Apoetm1Bres/Apoe+
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c) or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
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Allelic Composition: Apptm1Cwe/Apptm1Cwe
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019518 Ap4m1 / Q9JKC7 / AP-4 complex subunit mu-1 / O00189* / adaptor related protein complex 4 mu 1 subunit*  / reaction / complex
 ENSMUSG00000032952 Ap4b1 / Q9WV76 / AP-4 complex subunit beta-1 / Q9Y6B7* / adaptor related protein complex 4 beta 1 subunit*  / reaction / complex
 ENSMUSG00000079700 Fpr3 / O08790 / Formyl peptide receptor-related sequence 1 / FPR2* / P25090* / formyl peptide receptor 2*  / reaction / complex
 ENSMUSG00000041936 Agrn / A2ASQ1 / Agrin Agrin N-terminal 110 kDa subunit Agrin C-terminal 110 kDa subunit Agrin C-terminal 90 kDa fragment Agrin C-terminal 22 kDa fragment / agrin* / O00468*  / complex / reaction
 ENSMUSG00000052270 Fpr2 / O88536 / Formyl peptide receptor 2 / P25090*  / reaction / complex
 ENSMUSG00000020955 Ap4s1 / Q9WVL1 / AP-4 complex subunit sigma-1 / Q9Y587* / adaptor related protein complex 4 sigma 1 subunit*  / reaction / complex
 ENSMUSG00000001998 Ap4e1 / Q80V94 / AP-4 complex subunit epsilon-1 / Q9UPM8* / adaptor related protein complex 4 epsilon 1 subunit*  / reaction / complex
 ENSMUSG00000022892 App / P12023 / amyloid beta (A4) precursor protein / P05067* / amyloid beta precursor protein*  / -






 

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