ENSMUSG00000041936


Mus musculus

Features
Gene ID: ENSMUSG00000041936
  
Biological name :Agrn
  
Synonyms : A2ASQ1 / Agrin Agrin N-terminal 110 kDa subunit Agrin C-terminal 110 kDa subunit Agrin C-terminal 90 kDa fragment Agrin C-terminal 22 kDa fragment / Agrn
  
Possible biological names infered from orthology : agrin / O00468
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 156165290
Gene end: 156197488
  
Corresponding Affymetrix probe sets: 10519270 (MoGene1.0st)   1426670_at (Mouse Genome 430 2.0 Array)   1443980_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071229
Ensembl peptide - ENSMUSP00000101199
Ensembl peptide - ENSMUSP00000101200
Ensembl peptide - ENSMUSP00000137931
NCBI entrez gene - 11603     See in Manteia.
MGI - MGI:87961
RefSeq - XM_006538492
RefSeq - XM_006538496
RefSeq - XM_011250176
RefSeq - XM_011250177
RefSeq - XM_011250178
RefSeq - XM_017319921
RefSeq - NM_021604
RefSeq - XM_006538491
RefSeq - XM_006538493
RefSeq - XM_006538494
RefSeq - XM_006538495
RefSeq Peptide - NP_067617
swissprot - M0QWP1
swissprot - Z4YJS5
swissprot - Z4YK85
swissprot - A2ASQ1
Ensembl - ENSMUSG00000041936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agrnENSDARG00000079388Danio rerio
 AGRNENSGALG00000039193Gallus gallus
 AGRNENSG00000188157Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hspg2 / perlecan (heparan sulfate proteoglycan 2) / P98160* / heparan sulfate proteoglycan 2*ENSMUSG0000002876326
Egflam / Q4VBE4 / Pikachurin / Q63HQ2* / EGF like, fibronectin type III and laminin G domains*ENSMUSG0000004296112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000082  SEA domain
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002350  Kazal domain
 IPR003645  Follistatin-like, N-terminal
 IPR003884  Factor I / membrane attack complex
 IPR004850  NtA (N-terminal agrin) domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR036058  Kazal domain superfamily
 IPR036364  SEA domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0007009 plasma membrane organization IMP
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007528 neuromuscular junction development IGI
 biological_processGO:0008582 regulation of synaptic growth at neuromuscular junction IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0043087 regulation of GTPase activity IDA
 biological_processGO:0043113 receptor clustering IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IMP
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0045213 neurotransmitter receptor metabolic process IDA
 biological_processGO:0045887 positive regulation of synaptic growth at neuromuscular junction IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051491 positive regulation of filopodium assembly ISS
 biological_processGO:0055117 regulation of cardiac muscle contraction IDA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IDA
 biological_processGO:0086036 regulation of cardiac muscle cell membrane potential IDA
 biological_processGO:0099601 regulation of neurotransmitter receptor activity IEA
 biological_processGO:1903277 negative regulation of sodium ion export across plasma membrane IDA
 biological_processGO:1903407 negative regulation of sodium:potassium-exchanging ATPase activity IDA
 biological_processGO:2000541 positive regulation of protein geranylgeranylation IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005605 basal lamina IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0043083 synaptic cleft IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0002162 dystroglycan binding ISS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030548 acetylcholine receptor regulator activity IDA
 molecular_functionGO:0033691 sialic acid binding ISS
 molecular_functionGO:0035374 chondroitin sulfate binding IDA
 molecular_functionGO:0042030 ATPase inhibitor activity IDA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding ISS
 molecular_functionGO:0044325 ion channel binding IPI


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
ECM proteoglycans
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000751 myopathy "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574]
Show

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001052 abnormal muscle innervation "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: C57BL/6J-Agrnnmf380/J

Allelic Composition: Agrntm1Rwb/Agrntm1Rwb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: AgrnGt(Ex192)Byg/AgrnGt(Ex192)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agrntm3Jrs/Agrntm3Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: involves: C57BL/6J * DBA

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: involves: C57BL/6J * CAST

 MP:0001054 failure of presynaptic differentiation "inability of nerve terminals to find target and/or form terminal arbors for synaptic transmission" [J:61509]
Show

Allelic Composition: Chattm1Fhg/Chattm1Fhg
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Agrntm4Jrs/Agrntm4Jrs,Chrna1tm1Klee/Chrna1tm1Klee,Chrna7tm1Bay/Chrna7tm1Bay
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: KitW-42J/Kit+,X/SryPOS-TIR
Genetic Background: involves: C57BL/6J

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-42J/Kit+,X/SryPOS-TIR
Genetic Background: involves: C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca1tm2Jp/Abca1+,Tg(APOA1)427Bres/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * CBA/J

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: involves: C57BL/6J * DBA

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agrntm3Jrs/Agrntm3Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Agrntm3Jrs/Agrntm3Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: B6.Cg-Ctslnkt

 MP:0002923 increased post-tetanic potential "increase in the size or duration of potentials that persist after tetanic stimulation of central synapses" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Itpr3tf/Itpr3tf,Prkralear-5J/Prkralear-5J
Genetic Background: BTBR-Prkralear-5J Itpr3tf/GrsrJ

 MP:0003807 camptodactyly "permanant flexion of one or more digits; contractures may also be seen in the wrists and at the elbows" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: C57BL/6J-Agrnnmf380/J

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: C57BL/6J-Agrnnmf380/J

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: C57BL/6J-Agrnnmf380/J

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: involves: C57BL/6J * DBA

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agrnnmf380/Agrnnmf380
Genetic Background: C57BL/6J-Agrnnmf380/J

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Agrntm3Jrs/Agrntm3Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: AgrnGt(Ex192)Byg/AgrnGt(Ex192)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(NOS3)3Crom/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Agrntm1Rwb/Agrntm1Rwb,Tg(Pax3-cre)1Joe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Agrntm3Jrs/Agrntm3Jrs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
Show

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
Show

Allelic Composition: Ctslnkt/Ctslnkt
Genetic Background: C.Cg-Ctslnkt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022892 App / P12023 / amyloid beta (A4) precursor protein / P05067* / amyloid beta precursor protein*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr