ENSGALG00000039193


Gallus gallus

Features
Gene ID: ENSGALG00000039193
  
Biological name :AGRN
  
Synonyms : agrin / AGRN
  
Possible biological names infered from orthology : A2ASQ1 / Agrin Agrin N-terminal 110 kDa subunit Agrin C-terminal 110 kDa subunit Agrin C-terminal 90 kDa fragment Agrin C-terminal 22 kDa fragment / O00468
  
Species: Gallus gallus
  
Chr. number: 21
Strand: -1
Band:
Gene start: 2702980
Gene end: 2766080
  
Corresponding Affymetrix probe sets: Gga.16642.1.S1_at (Chicken Array)   Gga.4448.1.S1_at (Chicken Array)   Gga.4448.2.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045270
Ensembl peptide - ENSGALP00000059759
Ensembl peptide - ENSGALP00000052205
Ensembl peptide - ENSGALP00000047647
NCBI entrez gene - 396538     See in Manteia.
RefSeq - XM_015296845
RefSeq - XM_015296840
RefSeq - XM_015296841
RefSeq - XM_015296842
RefSeq - XM_015296843
RefSeq - XM_015296844
RefSeq - NM_205527
RefSeq - XM_015296839
RefSeq Peptide - NP_990858
swissprot - A0A1L1RLW7
swissprot - A0A1D5PHC7
swissprot - A0A1D5P4N5
swissprot - A0A1D5NY15
Ensembl - ENSGALG00000039193
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agrnENSDARG00000079388Danio rerio
 AGRNENSG00000188157Homo sapiens
 AgrnENSMUSG00000041936Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSPG2 / heparan sulfate proteoglycan 2 / P98160* / perlecan (heparan sulfate proteoglycan 2)*ENSGALG0000003571722
EGFLAM / EGF like, fibronectin type III and laminin G domains / Q4VBE4* / Q63HQ2* / Pikachurin *ENSGALG0000000372611
ENSGALG000000312626
EYS* / Q5T1H1* / eyes shut homolog (Drosophila)*ENSGALG000000162635


Protein motifs (from Interpro)
Interpro ID Name
 IPR000082  SEA domain
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002350  Kazal domain
 IPR003645  Follistatin-like, N-terminal
 IPR003884  Factor I / membrane attack complex
 IPR004850  NtA (N-terminal agrin) domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007158 neuron cell-cell adhesion TAS
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007528 neuromuscular junction development TAS
 biological_processGO:0010977 negative regulation of neuron projection development IDA
 biological_processGO:0043113 receptor clustering IEA
 biological_processGO:0071340 skeletal muscle acetylcholine-gated channel clustering IDA
 biological_processGO:0099601 regulation of neurotransmitter receptor activity IEA
 cellular_componentGO:0005576 extracellular region IMP
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031012 extracellular matrix TAS
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0045178 basal part of cell IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0002162 dystroglycan binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005539 glycosaminoglycan binding IMP
 molecular_functionGO:0030548 acetylcholine receptor regulator activity IMP
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0043237 laminin-1 binding IDA
 molecular_functionGO:0050840 extracellular matrix binding IMP


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000015770 APP / amyloid beta A4 protein precursor / P05067* / P12023* / amyloid beta precursor protein* / amyloid beta (A4) precursor protein*  / reaction / complex






 

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contact: otassy@igbmc.fr