ENSDARG00000079388


Danio rerio

Features
Gene ID: ENSDARG00000079388
  
Biological name :agrn
  
Synonyms : agrin / agrn
  
Possible biological names infered from orthology : A2ASQ1 / Agrin Agrin N-terminal 110 kDa subunit Agrin C-terminal 110 kDa subunit Agrin C-terminal 90 kDa fragment Agrin C-terminal 22 kDa fragment / O00468
  
Species: Danio rerio
  
Chr. number: 23
Strand: 1
Band:
Gene start: 23485858
Gene end: 23914687
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133459
Ensembl peptide - ENSDARP00000101095
NCBI entrez gene - 565373     See in Manteia.
RefSeq - NM_001177452
RefSeq - XM_009296864
RefSeq - XM_009296863
RefSeq - XM_021469837
RefSeq - XM_021469833
RefSeq Peptide - NP_001170923
swissprot - F1R074
swissprot - A0A0R4IJ40
ZFIN ID - ZDB-GENE-030131-1033
Ensembl - ENSDARG00000079388
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AGRNENSGALG00000039193Gallus gallus
 AGRNENSG00000188157Homo sapiens
 AgrnENSMUSG00000041936Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hspg2 / heparan sulfate proteoglycan 2 / P98160* / perlecan (heparan sulfate proteoglycan 2)*ENSDARG0000007656421
CT737133.1 / EGFLAM* / Q63HQ2* / EGF like, fibronectin type III and laminin G domains*ENSDARG0000009900812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000082  SEA domain
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002350  Kazal domain
 IPR003645  Follistatin-like, N-terminal
 IPR003884  Factor I / membrane attack complex
 IPR004850  NtA (N-terminal agrin) domain
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007213 G-protein coupled acetylcholine receptor signaling pathway IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007422 peripheral nervous system development IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0043113 receptor clustering IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0043236 laminin binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer decreased size , abnormal
retinal ganglion cell layer apoptotic , abnormal
retinal ganglion cell layer neuron projection mislocalised , abnormal
Show

 ZFA:0000029 hindbrain hindbrain neuron decreased amount , abnormal
hindbrain decreased amount , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary aplastic , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000075 spinal cord spinal cord neuron decreased amount , abnormal
Show

 ZFA:0000107 eye eye apoptotic , abnormal
eye decreased size , abnormal
eye decreased amount , abnormal
Show

 ZFA:0000109 forebrain forebrain decreased amount , abnormal
Show

 ZFA:0000155 somite somite morphology , abnormal
somite decreased size , abnormal
Show

 ZFA:0000310 cranial nerve VI cranial nerve VI axon decreased length , abnormal
Show

 ZFA:0000435 cranial nerve II cranial nerve II decreased size , abnormal
cranial nerve II axon decreased amount , abnormal
Show

 ZFA:0000453 cranial nerve X cranial nerve X axon decreased length , abnormal
Show

 ZFA:0000668 cranial nerve IX cranial nerve IX axon decreased length , abnormal
Show

 ZFA:0000697 cranial nerve V cranial nerve V axon decreased length , abnormal
cranial nerve V axon defasciculated , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism immobile , abnormal
Show

 ZFA:0001106 pharyngeal pouch pharyngeal pouch morphology , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region curvature , abnormal
Show

 ZFA:0001291 facial ganglion facial ganglion decreased size , abnormal
Show

 ZFA:0001365 trigeminal motor nucleus trigeminal motor nucleus decreased size , abnormal
Show

 ZFA:0001462 somite border somite border morphology , abnormal
Show

 ZFA:0001479 lateral line nerve lateral line nerve axon decreased length , abnormal
Show

 ZFA:0009053 sensory neuron sensory neuron morphology , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron axon decreased length , abnormal
Rohon-Beard neuron axon decreased amount , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron axon decreased length , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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