ENSDARG00000076564


Danio rerio

Features
Gene ID: ENSDARG00000076564
  
Biological name :hspg2
  
Synonyms : heparan sulfate proteoglycan 2 / hspg2
  
Possible biological names infered from orthology : P98160 / perlecan (heparan sulfate proteoglycan 2)
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 26543716
Gene end: 26725637
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000141317
Ensembl peptide - ENSDARP00000100979
Ensembl peptide - ENSDARP00000104137
swissprot - A0A0R4IZA6
swissprot - F1R5K7
swissprot - F1RCP6
ZFIN ID - ZDB-GENE-080807-4
Ensembl - ENSDARG00000076564
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HSPG2ENSGALG00000035717Gallus gallus
 HSPG2ENSG00000142798Homo sapiens
 Hspg2ENSMUSG00000028763Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
agrn / agrin / A2ASQ1* / O00468* / Agrin Agrin N-terminal 110 kDa subunit Agrin C-terminal 110 kDa subunit Agrin C-terminal 90 kDa fragment Agrin C-terminal 22 kDa fragment*ENSDARG0000007938812
CT737133.1 / EGFLAM* / Q63HQ2* / EGF like, fibronectin type III and laminin G domains*ENSDARG000000990087


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000082  SEA domain
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR002049  Laminin EGF domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013098  Immunoglobulin I-set
 IPR013151  Immunoglobulin
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001935 endothelial cell proliferation IMP
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0043534 blood vessel endothelial cell migration IMP
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Integrin cell surface interactions
Laminin interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle elongated , abnormal
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 ZFA:0000010 cardiovascular system cardiovascular system morphology , abnormal
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 ZFA:0000014 dorsal aorta dorsal aorta collapsed , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000471 atrium atrium elongated , abnormal
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 ZFA:0000473 trunk musculature trunk musculature dystrophic , abnormal
trunk musculature striated muscle thin filament decreased amount , abnormal
trunk musculature myofibril misaligned with trunk musculature myofibril, abnormal
trunk musculature refractivity , abnormal
trunk musculature sarcomere morphology , abnormal
trunk musculature mitochondrial matrix absent , abnormal
trunk musculature actin filament bundle disorganized , abnormal
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 ZFA:0001056 myotome myotome morphology , abnormal
myotome vacuolated , abnormal
myotome shape , abnormal
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 ZFA:0001089 myoseptum myoseptum U-shaped , abnormal
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 ZFA:0001094 whole organism whole organism decreased length , abnormal
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 ZFA:0001115 trunk trunk kinked , abnormal
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 ZFA:0001117 post-vent region post-vent region curved dorsal , abnormal
post-vent region curved ventral , abnormal
post-vent region kinked , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
intersegmental vessel unlumenized , abnormal
intersegmental vessel blood vessel endothelial cell decreased amount , abnormal
intersegmental vessel decreased length , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel aplastic , abnormal
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 ZFA:0005035 subintestinal vein subintestinal vein aplastic , abnormal
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 ZFA:0005314 blood vessel blood vessel decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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