ENSGALG00000015770


Gallus gallus

Features
Gene ID: ENSGALG00000015770
  
Biological name :APP
  
Synonyms : amyloid beta A4 protein precursor / APP
  
Possible biological names infered from orthology : amyloid beta (A4) precursor protein / amyloid beta precursor protein / P05067 / P12023
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 102609866
Gene end: 102809834
  
Corresponding Affymetrix probe sets: Gga.4613.1.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000001894
Ensembl peptide - ENSGALP00000064392
Ensembl peptide - ENSGALP00000058783
Ensembl peptide - ENSGALP00000036014
NCBI entrez gene - 374198     See in Manteia.
RefSeq - NM_204308
RefSeq - XM_015299094
RefSeq Peptide - NP_989639
swissprot - E1C440
swissprot - F1P0B2
swissprot - A0A1L1RZU6
swissprot - A0A1L1RJ57
Ensembl - ENSGALG00000015770
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 appaENSDARG00000104279Danio rerio
 APPENSG00000142192Homo sapiens
 AppENSMUSG00000022892Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APLP2 / Q06335* / Q06481* / Amyloid-like protein 2 * / amyloid beta precursor like protein 2*ENSGALG0000000125052


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008154  Amyloidogenic glycoprotein, extracellular
 IPR008155  Amyloidogenic glycoprotein
 IPR011178  Amyloidogenic glycoprotein, copper-binding
 IPR013803  Amyloidogenic glycoprotein, amyloid-beta peptide
 IPR015849  Amyloidogenic glycoprotein, heparin-binding
 IPR019543  Beta-amyloid precursor protein C-terminal
 IPR019744  Amyloidogenic glycoprotein, extracellular domain conserved site
 IPR019745  Amyloidogenic glycoprotein, intracellular domain, conserved site
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR024329  Amyloidogenic glycoprotein, E2 domain
 IPR028866  Amyloid beta A4 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0002265 astrocyte activation involved in immune response IEA
 biological_processGO:0006378 mRNA polyadenylation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006878 cellular copper ion homeostasis IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007176 regulation of epidermal growth factor-activated receptor activity IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007617 mating behavior IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008088 axo-dendritic transport IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0009987 cellular process IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IEA
 biological_processGO:0014005 microglia development IEA
 biological_processGO:0016199 axon midline choice point recognition IEA
 biological_processGO:0016322 neuron remodeling IEA
 biological_processGO:0016358 dendrite development IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032640 tumor necrosis factor production IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0040014 regulation of multicellular organism growth IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0043393 regulation of protein binding IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048143 astrocyte activation IEA
 biological_processGO:0048169 regulation of long-term neuronal synaptic plasticity IEA
 biological_processGO:0048669 collateral sprouting in absence of injury IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050803 regulation of synapse structure or activity IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0050885 neuromuscular process controlling balance IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051124 synaptic growth at neuromuscular junction IEA
 biological_processGO:0051247 positive regulation of protein metabolic process IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051563 smooth endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0061890 positive regulation of astrocyte activation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090647 modulation of age-related behavioral decline IEA
 biological_processGO:0098815 modulation of excitatory postsynaptic potential IEA
 biological_processGO:0150003 regulation of spontaneous synaptic transmission IEA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1903980 positive regulation of microglial cell activation IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:1905908 positive regulation of amyloid fibril formation IEA
 biological_processGO:1990000 amyloid fibril formation IEA
 biological_processGO:1990535 neuron projection maintenance IEA
 biological_processGO:2000406 positive regulation of T cell migration IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005641 nuclear envelope lumen IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030134 COPII-coated ER to Golgi transport vesicle IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0035253 ciliary rootlet IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0051233 spindle midzone IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046914 transition metal ion binding IEA
 molecular_functionGO:0051425 PTB domain binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ECM proteoglycans
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
G alpha (i) signalling events
Lysosome Vesicle Biogenesis
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000015770 APP / amyloid beta A4 protein precursor / P05067* / P12023* / amyloid beta precursor protein* / amyloid beta (A4) precursor protein*  / -
 ENSGALG00000039193 AGRN / agrin / A2ASQ1* / O00468* / Agrin Agrin N-terminal 110 kDa subunit Agrin C-terminal 110 kDa subunit Agrin C-terminal 90 kDa fragment Agrin C-terminal 22 kDa fragment*  / reaction / complex






 

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