ENSDARG00000104279


Danio rerio

Features
Gene ID: ENSDARG00000104279
  
Biological name :appa
  
Synonyms : amyloid beta (A4) precursor protein a / appa
  
Possible biological names infered from orthology : amyloid beta (A4) precursor protein / amyloid beta precursor protein / APP / P05067 / P12023
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 617620
Gene end: 656693
  
Corresponding Affymetrix probe sets: Dr.1442.2.S1_a_at (Zebrafish Array)   Dr.1442.2.S2_a_at (Zebrafish Array)   Dr.22516.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000130555
Ensembl peptide - ENSDARP00000136061
Ensembl peptide - ENSDARP00000136859
Ensembl peptide - ENSDARP00000141303
swissprot - A0A0R4IAB7
swissprot - A0A0R4IM64
swissprot - A0A0R4IN41
swissprot - A0A0R4IZ16
ZFIN ID - ZDB-GENE-000616-13
Ensembl - ENSDARG00000104279
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APPENSGALG00000015770Gallus gallus
 APPENSG00000142192Homo sapiens
 AppENSMUSG00000022892Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
appb / amyloid beta (A4) precursor protein bENSDARG0000005554371
aplp2 / amyloid beta (A4) precursor-like protein 2 / Q06335* / Q06481* / Amyloid-like protein 2 * / amyloid beta precursor like protein 2*ENSDARG0000005486432
aplp1 / amyloid beta (A4) precursor-like protein 1 / P51693* / amyloid beta precursor like protein 1*ENSDARG0000009836829


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008154  Amyloidogenic glycoprotein, extracellular
 IPR008155  Amyloidogenic glycoprotein
 IPR011178  Amyloidogenic glycoprotein, copper-binding
 IPR013803  Amyloidogenic glycoprotein, amyloid-beta peptide
 IPR015849  Amyloidogenic glycoprotein, heparin-binding
 IPR019543  Beta-amyloid precursor protein C-terminal
 IPR019744  Amyloidogenic glycoprotein, extracellular domain conserved site
 IPR019745  Amyloidogenic glycoprotein, intracellular domain, conserved site
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR024329  Amyloidogenic glycoprotein, E2 domain
 IPR028866  Amyloid beta A4 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001944 vasculature development IGI
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0060026 convergent extension IGI
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0046914 transition metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ECM proteoglycans
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
G alpha (i) signalling events
Lysosome Vesicle Biogenesis
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000012 central nervous system central nervous system morphology , abnormal
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 ZFA:0000737 cranium cranium edematous , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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