ENSDARG00000055543


Danio rerio

Features
Gene ID: ENSDARG00000055543
  
Biological name :appb
  
Synonyms : amyloid beta (A4) precursor protein b / appb
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 35026415
Gene end: 35155089
  
Corresponding Affymetrix probe sets: Dr.2615.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000072374
Ensembl peptide - ENSDARP00000112424
Ensembl peptide - ENSDARP00000110143
Ensembl peptide - ENSDARP00000072360
Ensembl peptide - ENSDARP00000072367
NCBI entrez gene - 170846     See in Manteia.
RefSeq - NM_152886
RefSeq Peptide - NP_690842
swissprot - F1R8S2
swissprot - B0V0E5
swissprot - F1RC40
swissprot - B0V0E4
ZFIN ID - ZDB-GENE-020220-1
Ensembl - ENSDARG00000055543
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
aplp2 / amyloid beta (A4) precursor-like protein 2 / Q06335* / Q06481* / Amyloid-like protein 2 * / amyloid beta precursor like protein 2*ENSDARG0000005486448
aplp1 / amyloid beta (A4) precursor-like protein 1 / P51693* / amyloid beta precursor like protein 1*ENSDARG0000009836838
appa / amyloid beta (A4) precursor protein a / APP* / P12023* / P05067* / amyloid beta precursor protein* / amyloid beta (A4) precursor protein*ENSDARG0000010427920


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008154  Amyloidogenic glycoprotein, extracellular
 IPR008155  Amyloidogenic glycoprotein
 IPR011178  Amyloidogenic glycoprotein, copper-binding
 IPR013803  Amyloidogenic glycoprotein, amyloid-beta peptide
 IPR015849  Amyloidogenic glycoprotein, heparin-binding
 IPR019543  Beta-amyloid precursor protein C-terminal
 IPR019744  Amyloidogenic glycoprotein, extracellular domain conserved site
 IPR019745  Amyloidogenic glycoprotein, intracellular domain, conserved site
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR024329  Amyloidogenic glycoprotein, E2 domain
 IPR028866  Amyloid beta A4 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001944 vasculature development IGI
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0045664 regulation of neuron differentiation IMP
 biological_processGO:0048675 axon extension IMP
 biological_processGO:0060026 convergent extension IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0046914 transition metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000006 ball ball increased size , abnormal
Show

 ZFA:0000012 central nervous system central nervous system malformed , abnormal
central nervous system morphology , abnormal
Show

 ZFA:0000029 hindbrain hindbrain increased amount , abnormal
hindbrain decreased amount , abnormal
hindbrain Notch signaling pathway increased occurrence , abnormal
hindbrain cell proliferation in hindbrain decreased occurrence , abnormal
hindbrain neuron differentiation decreased occurrence , abnormal
hindbrain has number of Mauthner neuron , ameliorated
hindbrain lacks parts or has fewer parts of type Mauthner neuron , abnormal
Show

 ZFA:0000084 yolk yolk decreased size , abnormal
Show

 ZFA:0000099 brain vasculature brain vasculature has fewer parts of type central artery , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000135 notochord notochord undulate , abnormal
notochord cell circular , abnormal
notochord increased width , abnormal
notochord bifurcated , abnormal
Show

 ZFA:0000155 somite somite increased width , abnormal
somite decreased width , abnormal
somite deformed , abnormal
Show

 ZFA:0000206 facial nerve motor nucleus facial nerve motor nucleus axon decreased length , abnormal
Show

 ZFA:0000737 cranium cranium edematous , abnormal
Show

 ZFA:0000948 rhombomere 3 rhombomere 3 decreased length , abnormal
Show

 ZFA:0001032 rhombomere 4 rhombomere 4 decreased length , abnormal
Show

 ZFA:0001056 myotome myotome increased width , abnormal
Show

 ZFA:0001058 caudal fin caudal fin curled , abnormal
caudal fin decreased length , abnormal
Show

 ZFA:0001094 whole organism whole organism shortened , abnormal
whole organism anterior-posterior axis decreased length , abnormal
whole organism decreased length , abnormal
whole organism decreased size , abnormal
Show

 ZFA:0001115 trunk trunk deformed , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region curved , abnormal
Show

 ZFA:0001365 trigeminal motor nucleus trigeminal motor nucleus axon decreased length , abnormal
Show

 ZFA:0005020 central artery central artery decreased length , abnormal
central artery decreased branchiness , abnormal
central artery shortened , abnormal
Show

 ZFA:0009052 motor neuron motor neuron axon decreased branchiness , abnormal
motor neuron cytoskeleton disorganized , abnormal
Show

 ZFA:0009139 endodermal cell endodermal cell mislocalised laterally , abnormal
Show

 ZFA:0009149 Mauthner neuron Mauthner neuron microtubule decreased amount , abnormal
Mauthner neuron microtubule cytoskeleton decreased mass density , abnormal
Show

 ZFA:0009243 CaP motoneuron CaP motoneuron axon decreased length , abnormal
CaP motoneuron axon increased branchiness , abnormal
CaP motoneuron axon extension decreased process quality , abnormal
Show

 ZFA:0009244 primary motor neuron primary motor neuron axon increased branchiness , abnormal
Show

 ZFA:0009247 secondary motor neuron secondary motor neuron axon extension decreased process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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