ENSDARG00000054864


Danio rerio

Features
Gene ID: ENSDARG00000054864
  
Biological name :aplp2
  
Synonyms : amyloid beta (A4) precursor-like protein 2 / aplp2
  
Possible biological names infered from orthology : amyloid beta precursor like protein 2 / Amyloid-like protein 2 / Q06335 / Q06481
  
Species: Danio rerio
  
Chr. number: 18
Strand: -1
Band:
Gene start: 44364530
Gene end: 44527124
  
Corresponding Affymetrix probe sets: Dr.14472.1.A1_at (Zebrafish Array)   Dr.25088.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000147863
Ensembl peptide - ENSDARP00000071593
NCBI entrez gene - 796801     See in Manteia.
RefSeq - NM_001123012
RefSeq Peptide - NP_001116484
swissprot - A2BID8
ZFIN ID - ZDB-GENE-061009-28
Ensembl - ENSDARG00000054864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APLP2ENSGALG00000001250Gallus gallus
 APLP2ENSG00000084234Homo sapiens
 Aplp2ENSMUSG00000031996Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
appb / amyloid beta (A4) precursor protein bENSDARG0000005554343
aplp1 / amyloid beta (A4) precursor-like protein 1 / P51693* / amyloid beta precursor like protein 1*ENSDARG0000009836837
appa / amyloid beta (A4) precursor protein a / APP* / P12023* / P05067* / amyloid beta precursor protein* / amyloid beta (A4) precursor protein*ENSDARG000001042798


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008154  Amyloidogenic glycoprotein, extracellular
 IPR008155  Amyloidogenic glycoprotein
 IPR011178  Amyloidogenic glycoprotein, copper-binding
 IPR015849  Amyloidogenic glycoprotein, heparin-binding
 IPR019543  Beta-amyloid precursor protein C-terminal
 IPR019744  Amyloidogenic glycoprotein, extracellular domain conserved site
 IPR019745  Amyloidogenic glycoprotein, intracellular domain, conserved site
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR024329  Amyloidogenic glycoprotein, E2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0046914 transition metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation blood vasculature , abnormal
Show

 ZFA:0000114 heart heart non-functional , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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