ENSG00000084234


Homo sapiens

Features
Gene ID: ENSG00000084234
  
Biological name :APLP2
  
Synonyms : amyloid beta precursor like protein 2 / APLP2 / Q06481
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q24.3
Gene start: 130069837
Gene end: 130144811
  
Corresponding Affymetrix probe sets: 208248_x_at (Human Genome U133 Plus 2.0 Array)   208701_at (Human Genome U133 Plus 2.0 Array)   208702_x_at (Human Genome U133 Plus 2.0 Array)   208703_s_at (Human Genome U133 Plus 2.0 Array)   208704_x_at (Human Genome U133 Plus 2.0 Array)   211404_s_at (Human Genome U133 Plus 2.0 Array)   214875_x_at (Human Genome U133 Plus 2.0 Array)   228520_s_at (Human Genome U133 Plus 2.0 Array)   243854_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345444
Ensembl peptide - ENSP00000433582
Ensembl peptide - ENSP00000435914
Ensembl peptide - ENSP00000435470
Ensembl peptide - ENSP00000434592
Ensembl peptide - ENSP00000434379
Ensembl peptide - ENSP00000434059
Ensembl peptide - ENSP00000263574
Ensembl peptide - ENSP00000263575
Ensembl peptide - ENSP00000278756
NCBI entrez gene - 334     See in Manteia.
OMIM - 104776
RefSeq - NM_001642
RefSeq - NM_001142276
RefSeq - NM_001142277
RefSeq - NM_001142278
RefSeq - NM_001243299
RefSeq Peptide - NP_001135748
RefSeq Peptide - NP_001135749
RefSeq Peptide - NP_001135750
RefSeq Peptide - NP_001230228
RefSeq Peptide - NP_001633
swissprot - Q9UED0
swissprot - E9PQS3
swissprot - E9PPD0
swissprot - E9PK76
swissprot - A0A140VJE9
swissprot - Q06481
swissprot - E9PSC7
Ensembl - ENSG00000084234
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aplp2ENSDARG00000054864Danio rerio
 APLP2ENSGALG00000001250Gallus gallus
 Aplp2ENSMUSG00000031996Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APP / P05067 / amyloid beta precursor proteinENSG0000014219249
APLP1 / P51693 / amyloid beta precursor like protein 1ENSG0000010529033


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008154  Amyloidogenic glycoprotein, extracellular
 IPR008155  Amyloidogenic glycoprotein
 IPR011178  Amyloidogenic glycoprotein, copper-binding
 IPR015849  Amyloidogenic glycoprotein, heparin-binding
 IPR019543  Beta-amyloid precursor protein C-terminal
 IPR019744  Amyloidogenic glycoprotein, extracellular domain conserved site
 IPR019745  Amyloidogenic glycoprotein, intracellular domain, conserved site
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR024329  Amyloidogenic glycoprotein, E2 domain
 IPR036176  E2 domain superfamily
 IPR036454  Amyloidogenic glycoprotein, heparin-binding domain superfamily
 IPR036669  Amyloidogenic glycoprotein, copper-binding domain superfamily
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway NAS
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0031092 platelet alpha granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003677 DNA binding NAS
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046914 transition metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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