ENSMUSG00000031996


Mus musculus

Features
Gene ID: ENSMUSG00000031996
  
Biological name :Aplp2
  
Synonyms : Amyloid-like protein 2 / Aplp2 / Q06335
  
Possible biological names infered from orthology : amyloid beta precursor like protein 2 / Q06481
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 31149557
Gene end: 31211815
  
Corresponding Affymetrix probe sets: 10592023 (MoGene1.0st)   1421887_a_at (Mouse Genome 430 2.0 Array)   1421888_x_at (Mouse Genome 430 2.0 Array)   1421889_a_at (Mouse Genome 430 2.0 Array)   1423739_x_at (Mouse Genome 430 2.0 Array)   1432344_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072428
Ensembl peptide - ENSMUSP00000078694
Ensembl peptide - ENSMUSP00000149023
Ensembl peptide - ENSMUSP00000149732
NCBI entrez gene - 11804     See in Manteia.
MGI - MGI:88047
RefSeq - XM_006509952
RefSeq - NM_001102455
RefSeq - NM_001102456
RefSeq - NM_009691
RefSeq - XM_006509951
RefSeq Peptide - NP_033821
RefSeq Peptide - NP_001095926
RefSeq Peptide - NP_001095925
swissprot - A0A1L1SS44
swissprot - Q60709
swissprot - Q06335
swissprot - Q64348
Ensembl - ENSMUSG00000031996
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aplp2ENSDARG00000054864Danio rerio
 APLP2ENSGALG00000001250Gallus gallus
 APLP2ENSG00000084234Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
App / P12023 / amyloid beta (A4) precursor protein / P05067* / amyloid beta precursor protein*ENSMUSG0000002289245
Aplp1 / amyloid beta precursor like protein 1 / P51693*ENSMUSG0000000665134


Protein motifs (from Interpro)
Interpro ID Name
 IPR002223  Pancreatic trypsin inhibitor Kunitz domain
 IPR008154  Amyloidogenic glycoprotein, extracellular
 IPR008155  Amyloidogenic glycoprotein
 IPR011178  Amyloidogenic glycoprotein, copper-binding
 IPR015849  Amyloidogenic glycoprotein, heparin-binding
 IPR019543  Beta-amyloid precursor protein C-terminal
 IPR019744  Amyloidogenic glycoprotein, extracellular domain conserved site
 IPR019745  Amyloidogenic glycoprotein, intracellular domain, conserved site
 IPR020901  Proteinase inhibitor I2, Kunitz, conserved site
 IPR024329  Amyloidogenic glycoprotein, E2 domain
 IPR036176  E2 domain superfamily
 IPR036454  Amyloidogenic glycoprotein, heparin-binding domain superfamily
 IPR036669  Amyloidogenic glycoprotein, copper-binding domain superfamily
 IPR036880  Pancreatic trypsin inhibitor Kunitz domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001967 suckling behavior IGI
 biological_processGO:0006878 cellular copper ion homeostasis IMP
 biological_processGO:0007176 regulation of epidermal growth factor-activated receptor activity IGI
 biological_processGO:0007617 mating behavior IGI
 biological_processGO:0007626 locomotory behavior IGI
 biological_processGO:0008203 cholesterol metabolic process IGI
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030198 extracellular matrix organization IGI
 biological_processGO:0030900 forebrain development IGI
 biological_processGO:0030901 midbrain development IGI
 biological_processGO:0043393 regulation of protein binding IGI
 biological_processGO:0050885 neuromuscular process controlling balance IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046914 transition metal ion binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Chattm2(cre)Lowl/Chat+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm1.2Zhe
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm2.1Zhe/Apptm2.1Zhe
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1Dbo/Apptm3.1Zhe
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm3.1Zhe/Apptm3.1Zhe
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001411 spinning "compulsive rolling of the body" [J:17123]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Aplp2tm1.1Umu/Aplp2tm1.1Umu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.1Zhe/Apptm1.1Zhe,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap4e1tm1b(KOMP)Wtsi/Ap4e1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ap4e1tm1b(KOMP)Wtsi/Orl

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm2.1Zhe/Apptm2.1Zhe
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1.2Zhe/Apptm2.1Zhe
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1Dbo/Apptm1Dbo
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm1Dbo/Apptm3.1Zhe
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Apptm3.1Zhe/Apptm3.1Zhe
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Aplp2tm1Dbo/Aplp2tm1Dbo,Lrp4tm1Her/Lrp4tm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Tgfb1tm1Doe/Tgfb1tm1Doe
Genetic Background: involves: 129S2/SvPas * CF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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