ENSMUSG00000006651


Mus musculus

Features
Gene ID: ENSMUSG00000006651
  
Biological name :Aplp1
  
Synonyms : amyloid beta precursor like protein 1 / Aplp1
  
Possible biological names infered from orthology : P51693
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30434982
Gene end: 30445535
  
Corresponding Affymetrix probe sets: 10561927 (MoGene1.0st)   1416134_at (Mouse Genome 430 2.0 Array)   1435857_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006828
NCBI entrez gene - 11803     See in Manteia.
MGI - MGI:88046
RefSeq - NM_007467
RefSeq - XM_017321948
RefSeq Peptide - NP_031493
swissprot - A0A0R4IZZ1
Ensembl - ENSMUSG00000006651
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aplp1ENSDARG00000098368Danio rerio
 APLP1ENSG00000105290Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aplp2 / Q06335 / Amyloid-like protein 2 / Q06481* / amyloid beta precursor like protein 2*ENSMUSG0000003199639
App / P12023 / amyloid beta (A4) precursor protein / P05067* / amyloid beta precursor protein*ENSMUSG0000002289235


Protein motifs (from Interpro)
Interpro ID Name
 IPR008154  Amyloidogenic glycoprotein, extracellular
 IPR008155  Amyloidogenic glycoprotein
 IPR011178  Amyloidogenic glycoprotein, copper-binding
 IPR015849  Amyloidogenic glycoprotein, heparin-binding
 IPR019543  Beta-amyloid precursor protein C-terminal
 IPR019744  Amyloidogenic glycoprotein, extracellular domain conserved site
 IPR019745  Amyloidogenic glycoprotein, intracellular domain, conserved site
 IPR024329  Amyloidogenic glycoprotein, E2 domain
 IPR036176  E2 domain superfamily
 IPR036454  Amyloidogenic glycoprotein, heparin-binding domain superfamily
 IPR036669  Amyloidogenic glycoprotein, copper-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0071874 cellular response to norepinephrine stimulus IEA
 biological_processGO:0106072 negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0031694 alpha-2A adrenergic receptor binding IEA
 molecular_functionGO:0031695 alpha-2B adrenergic receptor binding IEA
 molecular_functionGO:0031696 alpha-2C adrenergic receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046914 transition metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rxratm2Ipc/Rxra+
Genetic Background: involves: 129/Sv

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Aplp1tm1Umu/Aplp1tm1Umu,Apptm2Cwe/Apptm2Cwe
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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