ENSG00000105290


Homo sapiens

Features
Gene ID: ENSG00000105290
  
Biological name :APLP1
  
Synonyms : amyloid beta precursor like protein 1 / APLP1 / P51693
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.12
Gene start: 35867899
Gene end: 35879791
  
Corresponding Affymetrix probe sets: 209462_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467854
Ensembl peptide - ENSP00000466623
Ensembl peptide - ENSP00000474762
Ensembl peptide - ENSP00000221891
Ensembl peptide - ENSP00000441501
Ensembl peptide - ENSP00000465694
Ensembl peptide - ENSP00000466116
Ensembl peptide - ENSP00000466576
NCBI entrez gene - 333     See in Manteia.
OMIM - 104775
RefSeq - XM_017026738
RefSeq - NM_001024807
RefSeq - NM_005166
RefSeq - XM_017026737
RefSeq Peptide - NP_001019978
RefSeq Peptide - NP_005157
swissprot - S4R3U6
swissprot - B7Z4G8
swissprot - P51693
swissprot - F5GZ08
swissprot - K7ELK0
swissprot - K7EMS1
swissprot - K7EMN4
swissprot - K7EQJ4
Ensembl - ENSG00000105290
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aplp1ENSDARG00000098368Danio rerio
 Aplp1ENSMUSG00000006651Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
APLP2 / Q06481 / amyloid beta precursor like protein 2ENSG0000008423438
APP / P05067 / amyloid beta precursor proteinENSG0000014219235


Protein motifs (from Interpro)
Interpro ID Name
 IPR008154  Amyloidogenic glycoprotein, extracellular
 IPR008155  Amyloidogenic glycoprotein
 IPR011178  Amyloidogenic glycoprotein, copper-binding
 IPR015849  Amyloidogenic glycoprotein, heparin-binding
 IPR019543  Beta-amyloid precursor protein C-terminal
 IPR019744  Amyloidogenic glycoprotein, extracellular domain conserved site
 IPR019745  Amyloidogenic glycoprotein, intracellular domain, conserved site
 IPR024329  Amyloidogenic glycoprotein, E2 domain
 IPR036176  E2 domain superfamily
 IPR036454  Amyloidogenic glycoprotein, heparin-binding domain superfamily
 IPR036669  Amyloidogenic glycoprotein, copper-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0071874 cellular response to norepinephrine stimulus IDA
 biological_processGO:0106072 negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
 cellular_componentGO:0005604 basement membrane TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0031694 alpha-2A adrenergic receptor binding IPI
 molecular_functionGO:0031695 alpha-2B adrenergic receptor binding IPI
 molecular_functionGO:0031696 alpha-2C adrenergic receptor binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046914 transition metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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