Manteia - Molecule gene

ENSMUSG00000001998

Mus musculus

Features

Gene ID:	ENSMUSG00000001998

Biological name :	Ap4e1

Synonyms :	AP-4 complex subunit epsilon-1 / Ap4e1 / Q80V94

Possible biological names infered from orthology :	adaptor related protein complex 4 epsilon 1 subunit / Q9UPM8

Species:	Mus musculus

Chr. number:	2
Strand:	1
Band:	F1
Gene start:	127008717
Gene end:	127067909

Corresponding Affymetrix probe sets:	10475686 (MoGene1.0st) 1440261_at (Mouse Genome 430 2.0 Array) 1456948_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000135599 Ensembl peptide - ENSMUSP00000135257 Ensembl peptide - ENSMUSP00000135449 Ensembl peptide - ENSMUSP00000002063 Ensembl peptide - ENSMUSP00000106023 Ensembl peptide - ENSMUSP00000106024 NCBI entrez gene - 108011 See in Manteia. MGI - MGI:1336993 RefSeq - XM_006498553 RefSeq - NM_175550 RefSeq - XM_006498548 RefSeq - XM_006498549 RefSeq - XM_006498550 RefSeq - XM_006498551 RefSeq Peptide - NP_780759 swissprot - Q80V94 swissprot - H3BK54 swissprot - H3BKM4 swissprot - H3BL03 swissprot - F6W7A9 swissprot - A2ASB3 Ensembl - ENSMUSG00000001998

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ap4e1	ENSDARG00000103684	Danio rerio
	ENSGALG00000032171	Gallus gallus
	ENSGALG00000030049	Gallus gallus
	ENSGALG00000038286	Gallus gallus
AP4E1	ENSG00000081014	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ap1g1 / P22892 / AP-1 complex subunit gamma-1 / O43747* / adaptor related protein complex 1 gamma 1 subunit*	ENSMUSG00000031731	17
Ap1g2 / O88512 / AP-1 complex subunit gamma-like 2 / O75843* / adaptor related protein complex 1 gamma 2 subunit*	ENSMUSG00000040701	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR002553	Clathrin/coatomer adaptor, adaptin-like, N-terminal
IPR011989	Armadillo-like helical
IPR016024	Armadillo-type fold
IPR017109	Adaptor protein complex AP-4, epsilon subunit
IPR028269	AP-4 complex subunit epsilon-1, C-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006886	intracellular protein transport	IEA
biological_process	GO:0015031	protein transport	IEA
biological_process	GO:0016192	vesicle-mediated transport	IEA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005802	trans-Golgi network	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0030117	membrane coat	IEA
cellular_component	GO:0030124	AP-4 adaptor complex	ISO
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Lysosome Vesicle Biogenesis

Golgi Associated Vesicle Biogenesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Akap9^{tm1a(KOMP)Wtsi}/Akap9^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Akap9^{tm1a(KOMP)Wtsi}/Wtsi
MP:0000223	decreased monocyte count	"fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Akap9^{tm1a(KOMP)Wtsi}/Akap9^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Akap9^{tm1a(KOMP)Wtsi}/Wtsi
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
MP:0000781	reduced size of corpus callosum	"smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm,Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺,Pten^tm1Hwu/Pten⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0001303	abnormal lens morphology	"malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
MP:0001488	increased startle reflex	"reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0001539	decreased number of caudal vertebrae	"reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm,Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺,Pten^tm1Hwu/Pten⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0002067	abnormal sensory capabilities/reflexes/nociception	"inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
MP:0002699	abnormal vitreous body	"anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm,Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺,Pten^tm1Hwu/Pten⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6 Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Bay Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Akap9^{tm1a(KOMP)Wtsi}/Akap9^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Akap9^{tm1a(KOMP)Wtsi}/Wtsi
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0003131	increased erythrocyte count	"greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg
MP:0003393	decreased cardiac output	"reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Bay
MP:0003733	abnormal inner nuclear layer morphology	"malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
MP:0003917	increased kidney weight	"greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0003929	decreased heart rate variability	"reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
MP:0003960	increased lean body mass	"more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Bay Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Orl Allelic Composition: Ap4e1^{tm1a(KOMP)Wtsi}/Ap4e1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd Allelic Composition: Ap4e1^{tm1a(KOMP)Wtsi}/Ap4e1^{tm1a(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Bay
MP:0005385	cardiovascular system phenotype		Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J
MP:0005562	decreased mean corpuscular hemoglobin	"less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Akap9^{tm1a(KOMP)Wtsi}/Akap9^{tm1a(KOMP)Wtsi} Genetic Background: B6JTyr;B6N-Akap9^{tm1a(KOMP)Wtsi}/Wtsi
MP:0005564	increased hemoglobin content	"increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg
MP:0005599	increased cardiac muscle contractility	"greater than the normal ability of the heart muscle to shorten or to develop increased tension " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg
MP:0005641	increased mean corpuscular hemoglobin concentration	"greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:8936]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd
MP:0008346	increased gamma-delta T cell number	"greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Braf^tm1Mmcm/Braf^tm1Mmcm,Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺,Pten^tm1Hwu/Pten⁺ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6
MP:0009141	increased prepulse inhibition	"increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Bay Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ucd Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Orl
MP:0010053	decreased grip strength	"reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Orl
MP:0010101	increased sacral vertebrae number	"increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0010123	increased bone mineral content	"elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J
MP:0010124	decreased bone mineral content	"reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Orl
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0011275	abnormal behavioral response to light	"unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J
MP:0011396	abnormal sleep behavior	"any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/J
MP:0011952	decreased cardiac stroke volume	"reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Bay
MP:0011965	decreased total retina thickness	"decreased width of the retina through the center plane" [MGI:csmith]	Show Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Ieg Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Orl
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi Allelic Composition: Ap4e1^{tm1b(KOMP)Wtsi}/Ap4e1^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Ap4e1^{tm1b(KOMP)Wtsi}/Bay
MP:0012765	decreased alpha-beta T cell number	"reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi
MP:0013026	decreased Ly6C low monocyte number	"decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]	Show Allelic Composition: Anks6^{tm1b(KOMP)Wtsi}/Anks6^{tm1b(KOMP)Wtsi} Genetic Background: C57BL/6N-Anks6^{tm1b(KOMP)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020955	Ap4s1 / Q9WVL1 / AP-4 complex subunit sigma-1 / Q9Y587* / adaptor related protein complex 4 sigma 1 subunit*	/ complex
ENSMUSG00000019518	Ap4m1 / Q9JKC7 / AP-4 complex subunit mu-1 / O00189* / adaptor related protein complex 4 mu 1 subunit*	/ complex
ENSMUSG00000032952	Ap4b1 / Q9WV76 / AP-4 complex subunit beta-1 / Q9Y6B7* / adaptor related protein complex 4 beta 1 subunit*	/ complex
ENSMUSG00000022892	App / P12023 / amyloid beta (A4) precursor protein / P05067* / amyloid beta precursor protein*	/ reaction / complex

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