ENSMUSG00000031731


Mus musculus

Features
Gene ID: ENSMUSG00000031731
  
Biological name :Ap1g1
  
Synonyms : AP-1 complex subunit gamma-1 / Ap1g1 / P22892
  
Possible biological names infered from orthology : adaptor related protein complex 1 gamma 1 subunit / O43747
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 109778554
Gene end: 109864204
  
Corresponding Affymetrix probe sets: 10575302 (MoGene1.0st)   1423388_at (Mouse Genome 430 2.0 Array)   1434081_at (Mouse Genome 430 2.0 Array)   1460658_at (Mouse Genome 430 2.0 Array)   1460712_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034171
Ensembl peptide - ENSMUSP00000090844
Ensembl peptide - ENSMUSP00000136724
NCBI entrez gene - 11765     See in Manteia.
MGI - MGI:101919
RefSeq - NM_009677
RefSeq - NM_001301211
RefSeq Peptide - NP_001288140
RefSeq Peptide - NP_033807
swissprot - P22892
swissprot - Q3TDN1
swissprot - Q8CBB7
Ensembl - ENSMUSG00000031731
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap1g1ENSDARG00000102394Danio rerio
 AP1G1ENSGALG00000000848Gallus gallus
 AP1G1ENSG00000166747Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ap1g2 / O88512 / AP-1 complex subunit gamma-like 2 / O75843* / adaptor related protein complex 1 gamma 2 subunit*ENSMUSG0000004070158
Ap4e1 / Q80V94 / AP-4 complex subunit epsilon-1 / Q9UPM8* / adaptor related protein complex 4 epsilon 1 subunit*ENSMUSG0000000199823


Protein motifs (from Interpro)
Interpro ID Name
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR008153  Gamma-adaptin ear (GAE) domain
 IPR011989  Armadillo-like helical
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR016024  Armadillo-type fold
 IPR017107  Adaptor protein complex AP-1, gamma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0035646 endosome to melanosome transport ISO
 biological_processGO:0043323 positive regulation of natural killer cell degranulation ISO
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity ISO
 biological_processGO:0090160 Golgi to lysosome transport ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network TAS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030121 AP-1 adaptor complex IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030136 clathrin-coated vesicle ISO
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0055037 recycling endosome ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017137 Rab GTPase binding ISO
 molecular_functionGO:0019894 kinesin binding ISO
 molecular_functionGO:0030742 GTP-dependent protein binding ISO


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000043 organ of Corti degeneration "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

Allelic Composition: Ap1g1fgt/Ap1g1fgt
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0004324 vestibular hair cell degeneration "degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0004328 decreased vestibular hair cell number "decreased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0004697 abnormal thyroid follicular cell "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0005307 head tossing "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

Allelic Composition: Ap1g1fgt/Ap1g1fgt
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0005546 choroidal neovascularization "new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Grid2Lc/Grid2ho-Nancy
Genetic Background: involves: C57BL/6 * STOCK MitfMi-wh

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

 MP:0012671 retinal spots "the appearance of roundish lesions on the retina, frequently white, and may be due to inflammation, degeneration, vasculitis, exudates, edema or mineral deposits" [MGI:csmith]
Show

Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Stat1tm1Rds/Stat1tm1Rds
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003033 Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*  / complex
 ENSMUSG00000003309 Ap1m2 / adaptor related protein complex 1 mu 2 subunit / Q9Y6Q5*  / complex
 ENSMUSG00000009090 Ap1b1 / O35643 / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA. / Q10567* / adaptor related protein complex 1 beta 1 subunit*  / complex
 ENSMUSG00000019785 Clvs2 / Q8BG92 / Clavesin-2 / Q5SYC1*  / complex
 ENSMUSG00000054702 Ap1s3 / Q7TN05 / AP-1 complex subunit sigma-3 / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*  / complex
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / complex / reaction
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / complex
 ENSMUSG00000031367 Ap1s2 / Q9DB50 / AP-1 complex subunit sigma-2 / P56377* / adaptor related protein complex 1 sigma 2 subunit*  / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000004849 Ap1s1 / P61967 / AP-1 complex subunit sigma-1A / P61966* / adaptor related protein complex 1 sigma 1 subunit*  / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / complex
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / complex
 ENSMUSG00000041216 Clvs1 / Q9D4C9 / Clavesin-1 / Q8IUQ0*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr