ENSMUSG00000041216


Mus musculus

Features
Gene ID: ENSMUSG00000041216
  
Biological name :Clvs1
  
Synonyms : Clavesin-1 / Clvs1 / Q9D4C9
  
Possible biological names infered from orthology : Q8IUQ0
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 9269293
Gene end: 9451691
  
Corresponding Affymetrix probe sets: 10503234 (MoGene1.0st)   1431684_at (Mouse Genome 430 2.0 Array)   1433906_at (Mouse Genome 430 2.0 Array)   1459941_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035649
Ensembl peptide - ENSMUSP00000103985
NCBI entrez gene - 74438     See in Manteia.
MGI - MGI:1921688
RefSeq - XM_011250125
RefSeq - NM_028940
RefSeq - XM_006538321
RefSeq - XM_006538322
RefSeq Peptide - NP_001342112
RefSeq Peptide - NP_083216
swissprot - Q9D4C9
Ensembl - ENSMUSG00000041216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clvs2ENSDARG00000053122Danio rerio
 CLVS1ENSG00000177182Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clvs2 / Q8BG92 / Clavesin-2 / Q5SYC1*ENSMUSG0000001978574
Rlbp1 / Q9Z275 / retinaldehyde binding protein 1 / P12271*ENSMUSG0000003919432
Ttpal / Q9D3D0 / tocopherol (alpha) transfer protein-like / Q9BTX7* / alpha tocopherol transfer protein like*ENSMUSG0000001767931
Ttpa / Q8BWP5 / tocopherol (alpha) transfer protein / P49638* / alpha tocopherol transfer protein*ENSMUSG0000007398824


Protein motifs (from Interpro)
Interpro ID Name
 IPR001251  CRAL-TRIO lipid binding domain
 IPR011074  CRAL/TRIO, N-terminal domain
 IPR028634  Clavesin-1
 IPR036273  CRAL/TRIO, N-terminal domain superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007040 lysosome organization ISS
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031901 early endosome membrane IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding ISS


Pathways (from Reactome)
Pathway description
Lysosome Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003795 abnormal bone structure 
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000009090 Ap1b1 / O35643 / Mus musculus adaptor protein complex AP-1, beta 1 subunit (Ap1b1), transcript variant 4, mRNA. / Q10567* / adaptor related protein complex 1 beta 1 subunit*  / complex
 ENSMUSG00000003309 Ap1m2 / adaptor related protein complex 1 mu 2 subunit / Q9Y6Q5*  / complex
 ENSMUSG00000031367 Ap1s2 / Q9DB50 / AP-1 complex subunit sigma-2 / P56377* / adaptor related protein complex 1 sigma 2 subunit*  / complex
 ENSMUSG00000031731 Ap1g1 / P22892 / AP-1 complex subunit gamma-1 / O43747* / adaptor related protein complex 1 gamma 1 subunit*  / complex
 ENSMUSG00000003033 Ap1m1 / P35585 / AP-1 complex subunit mu-1 / Q9BXS5* / adaptor related protein complex 1 mu 1 subunit*  / complex
 ENSMUSG00000004849 Ap1s1 / P61967 / AP-1 complex subunit sigma-1A / P61966* / adaptor related protein complex 1 sigma 1 subunit*  / complex
 ENSMUSG00000054702 Ap1s3 / Q7TN05 / AP-1 complex subunit sigma-3 / Q96PC3* / adaptor related protein complex 1 sigma 3 subunit*  / complex






 

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