ENSMUSG00000073988


Mus musculus

Features
Gene ID: ENSMUSG00000073988
  
Biological name :Ttpa
  
Synonyms : Q8BWP5 / tocopherol (alpha) transfer protein / Ttpa
  
Possible biological names infered from orthology : alpha tocopherol transfer protein / P49638
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A3
Gene start: 20007938
Gene end: 20030785
  
Corresponding Affymetrix probe sets: 10503502 (MoGene1.0st)   10503520 (MoGene1.0st)   1427284_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113026
Ensembl peptide - ENSMUSP00000117031
Ensembl peptide - ENSMUSP00000113966
Ensembl peptide - ENSMUSP00000095845
NCBI entrez gene - 50500     See in Manteia.
MGI - MGI:1354168
RefSeq - NM_001317723
RefSeq - XM_017320306
RefSeq - NM_015767
RefSeq Peptide - NP_001304652
RefSeq Peptide - NP_056582
swissprot - A8Y5P0
swissprot - A8Y5N9
swissprot - Q499J3
swissprot - Q8BWP5
swissprot - A2AIT6
Ensembl - ENSMUSG00000073988
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttpaENSDARG00000027584Danio rerio
 TTPAENSGALG00000030031Gallus gallus
 TTPAENSG00000137561Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ttpal / Q9D3D0 / tocopherol (alpha) transfer protein-like / Q9BTX7* / alpha tocopherol transfer protein like*ENSMUSG0000001767934
Clvs2 / Q8BG92 / Clavesin-2 / Q5SYC1*ENSMUSG0000001978532
Clvs1 / Q9D4C9 / Clavesin-1 / Q8IUQ0*ENSMUSG0000004121631
Rlbp1 / Q9Z275 / retinaldehyde binding protein 1 / P12271*ENSMUSG0000003919429


Protein motifs (from Interpro)
Interpro ID Name
 IPR001251  CRAL-TRIO lipid binding domain
 IPR011074  CRAL/TRIO, N-terminal domain
 IPR036273  CRAL/TRIO, N-terminal domain superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0009636 response to toxic substance IMP
 biological_processGO:0032502 developmental process IEA
 biological_processGO:0042360 vitamin E metabolic process IMP
 biological_processGO:0051180 vitamin transport IDA
 biological_processGO:0051452 intracellular pH reduction IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0090212 negative regulation of establishment of blood-brain barrier IMP
 biological_processGO:0120009 intermembrane lipid transfer IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008431 vitamin E binding IEA
 molecular_functionGO:0019842 vitamin binding IEA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA
 molecular_functionGO:0120013 intermembrane lipid transfer activity IDA


Pathways (from Reactome)
Pathway description
Vitamin E


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttpatm1Hsz/Ttpa+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000754 partial paralysis "partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ttpatm1Hsz/Ttpa+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001328 disorganized retinal layers "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Ttpatm1Hsz/Ttpa+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttpatm1Hsz/Ttpa+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001908 abnormal somatosensory cortex function "anomalous activity of the area of the parietal lobe concerned with receiving general sensations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Tsc2tm1Tno/Tsc2+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ttpatm1Hsz/Ttpa+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpatm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002730 head shaking "compulsive movement of the head in the horizontal plane" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:274]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005112 abnormal anterior horn morphology "anomalous structure of the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpatm1Far
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009403 increased variability of skeletal muscle fiber size "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011231 abnormal vitamin E level "any anomaly in the concentration of vitamin E, tocopherol, including a series of eight structurally similar compounds; alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant" [GO:0010189]
Show

Allelic Composition: Tsc2tm1Tno/Tsc2+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Ttpatm1Far/Ttpa+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ttpatm1Hsz/Ttpa+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ttpatm1Hsz/Ttpatm1Hsz
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ttpatm1Far/Ttpa+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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