ENSG00000166747


Homo sapiens

Features
Gene ID: ENSG00000166747
  
Biological name :AP1G1
  
Synonyms : adaptor related protein complex 1 gamma 1 subunit / AP1G1 / O43747
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: q22.2
Gene start: 71729000
Gene end: 71809201
  
Corresponding Affymetrix probe sets: 203350_at (Human Genome U133 Plus 2.0 Array)   225754_at (Human Genome U133 Plus 2.0 Array)   225771_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456058
Ensembl peptide - ENSP00000457927
Ensembl peptide - ENSP00000457726
Ensembl peptide - ENSP00000456493
Ensembl peptide - ENSP00000456316
Ensembl peptide - ENSP00000299980
Ensembl peptide - ENSP00000377148
Ensembl peptide - ENSP00000405836
Ensembl peptide - ENSP00000454219
Ensembl peptide - ENSP00000454523
Ensembl peptide - ENSP00000454713
Ensembl peptide - ENSP00000454717
Ensembl peptide - ENSP00000454932
Ensembl peptide - ENSP00000454970
Ensembl peptide - ENSP00000455400
NCBI entrez gene - 164     See in Manteia.
OMIM - 603533
RefSeq - NM_001030007
RefSeq - NM_001128
RefSeq Peptide - NP_001025178
RefSeq Peptide - NP_001119
swissprot - H3BNN2
swissprot - H3BNR4
swissprot - H3BPN9
swissprot - H3BR36
swissprot - H3BRM7
swissprot - H3BS13
swissprot - H3BUN9
swissprot - H3BV30
swissprot - B4DGE1
swissprot - O43747
swissprot - B3KNW1
swissprot - A0A140VJE7
swissprot - H3BN71
swissprot - H3BN75
Ensembl - ENSG00000166747
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap1g1ENSDARG00000102394Danio rerio
 AP1G1ENSGALG00000000848Gallus gallus
 Ap1g1ENSMUSG00000031731Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP1G2 / O75843 / adaptor related protein complex 1 gamma 2 subunitENSG0000021398359
AP4E1 / Q9UPM8 / adaptor related protein complex 4 epsilon 1 subunitENSG0000008101423


Protein motifs (from Interpro)
Interpro ID Name
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR008153  Gamma-adaptin ear (GAE) domain
 IPR011989  Armadillo-like helical
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR016024  Armadillo-type fold
 IPR017107  Adaptor protein complex AP-1, gamma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0032438 melanosome organization IC
 biological_processGO:0035646 endosome to melanosome transport IMP
 biological_processGO:0043323 positive regulation of natural killer cell degranulation IMP
 biological_processGO:0045954 positive regulation of natural killer cell mediated cytotoxicity IMP
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0090160 Golgi to lysosome transport IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005794 Golgi apparatus TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030119 AP-type membrane coat adaptor complex TAS
 cellular_componentGO:0030121 AP-1 adaptor complex IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0030665 clathrin-coated vesicle membrane ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0055037 recycling endosome IDA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017137 Rab GTPase binding IPI
 molecular_functionGO:0019894 kinesin binding IPI
 molecular_functionGO:0030742 GTP-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
Nef mediated downregulation of MHC class I complex cell surface expression
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129354 AP1M2 / Q9Y6Q5 / adaptor related protein complex 1 mu 2 subunit  / complex
 ENSG00000072958 AP1M1 / Q9BXS5 / adaptor related protein complex 1 mu 1 subunit  / complex
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000152056 AP1S3 / Q96PC3 / adaptor related protein complex 1 sigma 3 subunit  / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex
 ENSG00000182287 AP1S2 / P56377 / adaptor related protein complex 1 sigma 2 subunit  / complex
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex
 ENSG00000177182 CLVS1 / Q8IUQ0 / clavesin 1  / complex
 ENSG00000106367 AP1S1 / P61966 / adaptor related protein complex 1 sigma 1 subunit  / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex
 ENSG00000146352 CLVS2 / Q5SYC1 / clavesin 2  / complex
 ENSG00000100280 AP1B1 / Q10567 / adaptor related protein complex 1 beta 1 subunit  / complex
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex
 ENSG00000175115 PACS1 / Q6VY07 / phosphofurin acidic cluster sorting protein 1  / complex / reaction






 

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