ENSG00000100280


Homo sapiens

Features
Gene ID: ENSG00000100280
  
Biological name :AP1B1
  
Synonyms : adaptor related protein complex 1 beta 1 subunit / AP1B1 / Q10567
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q12.2
Gene start: 29327680
Gene end: 29423179
  
Corresponding Affymetrix probe sets: 205423_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392735
Ensembl peptide - ENSP00000400065
Ensembl peptide - ENSP00000400022
Ensembl peptide - ENSP00000319361
Ensembl peptide - ENSP00000350199
Ensembl peptide - ENSP00000384194
Ensembl peptide - ENSP00000386071
Ensembl peptide - ENSP00000387612
NCBI entrez gene - 162     See in Manteia.
OMIM - 600157
RefSeq - NM_001127
RefSeq - NM_001166019
RefSeq - NM_145730
RefSeq Peptide - NP_001118
RefSeq Peptide - NP_663782
RefSeq Peptide - NP_001159491
swissprot - Q10567
swissprot - H7C034
swissprot - C9J1E7
Ensembl - ENSG00000100280
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap1b1ENSDARG00000020621Danio rerio
 AP1B1ENSGALG00000042213Gallus gallus
 Ap1b1ENSMUSG00000009090Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunitENSG0000000612583
AP4B1 / Q9Y6B7 / adaptor related protein complex 4 beta 1 subunitENSG0000013426223


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002553  Clathrin/coatomer adaptor, adaptin-like, N-terminal
 IPR008152  Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
 IPR009028  Coatomer/calthrin adaptor appendage, C-terminal subdomain
 IPR011989  Armadillo-like helical
 IPR013037  Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain
 IPR013041  Clathrin adaptor, appendage, Ig-like subdomain superfamily
 IPR015151  Beta-adaptin appendage, C-terminal subdomain
 IPR016024  Armadillo-type fold
 IPR016342  AP-1/2/4 complex subunit beta
 IPR026739  AP complex subunit beta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0030276 clathrin binding IEA


Pathways (from Reactome)
Pathway description
Nef mediated downregulation of MHC class I complex cell surface expression
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129354 AP1M2 / Q9Y6Q5 / adaptor related protein complex 1 mu 2 subunit  / complex
 ENSG00000072958 AP1M1 / Q9BXS5 / adaptor related protein complex 1 mu 1 subunit  / complex
 ENSG00000166747 AP1G1 / O43747 / adaptor related protein complex 1 gamma 1 subunit  / complex
 ENSG00000152056 AP1S3 / Q96PC3 / adaptor related protein complex 1 sigma 3 subunit  / complex
 ENSG00000182287 AP1S2 / P56377 / adaptor related protein complex 1 sigma 2 subunit  / complex
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex
 ENSG00000146352 CLVS2 / Q5SYC1 / clavesin 2  / complex
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000106367 AP1S1 / P61966 / adaptor related protein complex 1 sigma 1 subunit  / complex
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex
 ENSG00000177182 CLVS1 / Q8IUQ0 / clavesin 1  / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction
 ENSG00000175115 PACS1 / Q6VY07 / phosphofurin acidic cluster sorting protein 1  / complex / reaction






 

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