Manteia

ENSG00000204287

Homo sapiens

Features

Gene ID:	ENSG00000204287

Biological name :	HLA-DRA

Synonyms :	HLA-DRA / major histocompatibility complex, class II, DR alpha / P01903

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	6
Strand:	1
Band:	p21.32
Gene start:	32439842
Gene end:	32445046

Corresponding Affymetrix probe sets:	208894_at (Human Genome U133 Plus 2.0 Array) 210982_s_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000364121 Ensembl peptide - ENSP00000378786 NCBI entrez gene - 3122 See in Manteia. OMIM - 142860 RefSeq - NM_019111 RefSeq Peptide - NP_061984 swissprot - P01903 swissprot - Q30118 Ensembl - ENSG00000204287

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CT583723.2	ENSDARG00000116565	Danio rerio
CU914776.2	ENSDARG00000114601	Danio rerio
si:busm1-194e12.11	ENSDARG00000103716	Danio rerio
si:busm1-194e12.8	ENSDARG00000103702	Danio rerio
si:busm1-266f07.2	ENSDARG00000031745	Danio rerio
si:ch73-211l2.3	ENSDARG00000075932	Danio rerio
si:zfos-2070c2.1	ENSDARG00000070206	Danio rerio
si:zfos-367g9.1	ENSDARG00000074816	Danio rerio
zgc:123107	ENSDARG00000101675	Danio rerio

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1	ENSG00000231389	59
P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1	ENSG00000196735	54
P06340 / HLA-DOA / major histocompatibility complex, class II, DO alpha	ENSG00000204252	54
P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2	ENSG00000237541	53
P28067 / HLA-DMA / major histocompatibility complex, class II, DM alpha	ENSG00000204257	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR001003	MHC class II, alpha chain, N-terminal
IPR003006	Immunoglobulin/major histocompatibility complex, conserved site
IPR003597	Immunoglobulin C1-set
IPR007110	Immunoglobulin-like domain
IPR011162	MHC classes I/II-like antigen recognition protein
IPR013783	Immunoglobulin-like fold
IPR014745	MHC class II, alpha/beta chain, N-terminal
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0002503	peptide antigen assembly with MHC class II protein complex	IDA
biological_process	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	IEA
biological_process	GO:0002506	polysaccharide assembly with MHC class II protein complex	IDA
biological_process	GO:0006955	immune response	IEA
biological_process	GO:0016032	viral process	IEA
biological_process	GO:0019882	antigen processing and presentation	IEA
biological_process	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	TAS
biological_process	GO:0031295	T cell costimulation	TAS
biological_process	GO:0050852	T cell receptor signaling pathway	TAS
biological_process	GO:0050890	cognition	IMP
biological_process	GO:0060333	interferon-gamma-mediated signaling pathway	TAS
cellular_component	GO:0000139	Golgi membrane	TAS
cellular_component	GO:0005764	lysosome	IDA
cellular_component	GO:0005765	lysosomal membrane	TAS
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005886	plasma membrane	IDA
cellular_component	GO:0005887	integral component of plasma membrane	NAS
cellular_component	GO:0009986	cell surface	IDA
cellular_component	GO:0010008	endosome membrane	IEA
cellular_component	GO:0012507	ER to Golgi transport vesicle membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030658	transport vesicle membrane	TAS
cellular_component	GO:0030666	endocytic vesicle membrane	TAS
cellular_component	GO:0030669	clathrin-coated endocytic vesicle membrane	TAS
cellular_component	GO:0031902	late endosome membrane	IEA
cellular_component	GO:0032588	trans-Golgi network membrane	TAS
cellular_component	GO:0042613	MHC class II protein complex	IEA
cellular_component	GO:0070062	extracellular exosome	HDA
cellular_component	GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0023026	MHC class II protein complex binding	HDA
molecular_function	GO:0032395	MHC class II receptor activity	NAS
molecular_function	GO:0042605	peptide antigen binding	IDA

Pathways (from Reactome)

Pathway description

Downstream TCR signaling

Phosphorylation of CD3 and TCR zeta chains

Translocation of ZAP-70 to Immunological synapse

Generation of second messenger molecules

MHC class II antigen presentation

PD-1 signaling

Interferon gamma signaling

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
HP:0000989	Pruritus	"Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus." [HPO:curators]	Show
HP:0001596	Alopecia	"Loss of hair from the head or body." [HPO:curators]	Show
HP:0002209	Sparse scalp hair	"Sparseness of the `head hair` (FMA:54241)." [HPO:probinson]	Show
HP:0002215	Sparse axillary hair		Show
HP:0002225	Sparse pubic hair		Show
HP:0007468	Perifollicular hyperkeratosis		Show
HP:0100725	Lichenification	"Thickening and hardenining of the epidermis seen with exaggeration of normal skin lines." [HPO:probinson]	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000010610	CD4 / P01730 / CD4 molecule	/ complex / reaction
ENSG00000019582	CD74 / P04233 / CD74 molecule	/ reaction / complex
ENSG00000103653	CSK / P41240 / C-terminal Src kinase	/ reaction
ENSG00000122705	CLTA / P09496 / clathrin light chain A	/ reaction / complex
ENSG00000129354	AP1M2 / Q9Y6Q5 / adaptor related protein complex 1 mu 2 subunit	/ complex
ENSG00000204252	P06340 / HLA-DOA / major histocompatibility complex, class II, DO alpha	/ reaction / complex
ENSG00000138802	O95487 / SEC24B / SEC24 homolog B, COPII coat complex component	/ complex / reaction
ENSG00000138674	O94979 / SEC31A / SEC31 homolog A, COPII coat complex component	/ complex / reaction
ENSG00000042753	AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit	/ reaction / complex
ENSG00000115085	ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70	/ complex / reaction
ENSG00000072958	AP1M1 / Q9BXS5 / adaptor related protein complex 1 mu 1 subunit	/ complex
ENSG00000167286	CD3D / P04234 / CD3d molecule	/ complex / reaction
ENSG00000100934	Q15436 / SEC23A / Sec23 homolog A, coat complex II component	/ reaction / complex
ENSG00000160654	CD3G / P09693 / CD3g molecule	/ complex / reaction
ENSG00000161203	AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit	/ reaction / complex
ENSG00000150961	O94855 / SEC24D / SEC24 homolog D, COPII coat complex component	/ complex / reaction
ENSG00000141367	CLTC / Q00610 / clathrin heavy chain	/ reaction / complex
ENSG00000166747	AP1G1 / O43747 / adaptor related protein complex 1 gamma 1 subunit	/ complex
ENSG00000152056	AP1S3 / Q96PC3 / adaptor related protein complex 1 sigma 3 subunit	/ complex
ENSG00000182287	AP1S2 / P56377 / adaptor related protein complex 1 sigma 2 subunit	/ complex
ENSG00000100280	AP1B1 / Q10567 / adaptor related protein complex 1 beta 1 subunit	/ complex
ENSG00000182866	LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase	/ complex / reaction
ENSG00000183020	AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit	/ complex / reaction
ENSG00000157020	SEC13 / P55735 / SEC13 homolog, nuclear pore and COPII coat complex component	/ complex / reaction
ENSG00000176986	P53992 / SEC24C / SEC24 homolog C, COPII coat complex component	/ complex / reaction
ENSG00000111679	PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6	/ reaction
ENSG00000100600	LGMN / Q99538 / legumain	/ reaction
ENSG00000113615	O95486 / SEC24A / SEC24 homolog A, COPII coat complex component	/ reaction / complex
ENSG00000106367	AP1S1 / P61966 / adaptor related protein complex 1 sigma 1 subunit	/ complex
ENSG00000196735	P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1	/ complex / reaction
ENSG00000198821	CD247 / P20963 / CD247 molecule	/ reaction / complex
ENSG00000196961	AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit	/ complex / reaction
ENSG00000079805	DNM2 / P50570 / dynamin 2	/ reaction / complex
ENSG00000179295	PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11	/ reaction
ENSG00000198851	CD3E / P07766 / CD3e molecule	/ reaction / complex
ENSG00000134242	PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22	/ reaction
ENSG00000163131	CTSS / P25774 / cathepsin S	/ reaction
ENSG00000241106	P13765 / HLA-DOB / major histocompatibility complex, class II, DO beta	/ complex / reaction
ENSG00000211799	TRAV19 / T cell receptor alpha variable 19	/ reaction / complex
ENSG00000089692	LAG3 / P18627 / lymphocyte activating 3	/ reaction / complex
ENSG00000065675	PRKCQ / Q04759 / protein kinase C theta	/ reaction
ENSG00000127022	CANX / P27824 / calnexin	/ complex / reaction
ENSG00000237541	P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2	/ complex / reaction
ENSG00000124181	PLCG1 / P19174 / phospholipase C gamma 1	/ reaction
ENSG00000204287	P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha	/ complex / reaction
ENSG00000107295	Q99962 / SH3GL2 / SH3 domain containing GRB2 like 2, endophilin A1	/ complex
ENSG00000213658	LAT / O43561 / linker for activation of T cells	/ reaction
ENSG00000231389	P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1	/ complex / reaction
ENSG00000043462	LCP2 / Q13094 / lymphocyte cytosolic protein 2	/ reaction
ENSG00000100351	GRAP2 / O75791 / GRB2-related adaptor protein 2	/ reaction
ENSG00000204257	P28067 / HLA-DMA / major histocompatibility complex, class II, DM alpha	/ complex / reaction
ENSG00000242574	P28068 / HLA-DMB / major histocompatibility complex, class II, DM beta	/ complex / reaction
ENSG00000152700	SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B	/ complex / reaction
ENSG00000149177	PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type J	/ reaction
ENSG00000006125	AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr