ENSG00000157020


Homo sapiens

Features
Gene ID: ENSG00000157020
  
Biological name :SEC13
  
Synonyms : P55735 / SEC13 / SEC13 homolog, nuclear pore and COPII coat complex component
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p25.3
Gene start: 10293131
Gene end: 10321178
  
Corresponding Affymetrix probe sets: 207707_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000373312
Ensembl peptide - ENSP00000380298
Ensembl peptide - ENSP00000404141
Ensembl peptide - ENSP00000401368
Ensembl peptide - ENSP00000400260
Ensembl peptide - ENSP00000398623
Ensembl peptide - ENSP00000380306
Ensembl peptide - ENSP00000312122
Ensembl peptide - ENSP00000336566
NCBI entrez gene - 6396     See in Manteia.
OMIM - 600152
RefSeq - NM_183352
RefSeq - XM_017007021
RefSeq - XM_017007020
RefSeq - XM_017007019
RefSeq - XM_005265379
RefSeq - NM_001136026
RefSeq - NM_001136232
RefSeq - NM_030673
RefSeq Peptide - NP_001129498
RefSeq Peptide - NP_001129704
RefSeq Peptide - NP_109598
RefSeq Peptide - NP_899195
swissprot - C9JIB6
swissprot - P55735
swissprot - A8MXL6
swissprot - E7ERC8
swissprot - C9J0S2
swissprot - C9JBJ5
Ensembl - ENSG00000157020
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sec13ENSDARG00000054807Danio rerio
 SEC13ENSGALG00000008419Gallus gallus
 Sec13ENSMUSG00000030298Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR036322  WD40-repeat-containing domain superfamily
 IPR037363  Sec13/Seh1 family
 IPR037596  Protein Sec13


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS
 biological_processGO:0006886 intracellular protein transport NAS
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0032008 positive regulation of TOR signaling IMP
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0090110 cargo loading into COPII-coated vesicle IDA
 biological_processGO:0090114 COPII-coated vesicle budding IEA
 biological_processGO:1904263 positive regulation of TORC1 signaling IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030127 COPII vesicle coat IDA
 cellular_componentGO:0031080 nuclear pore outer ring NAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0061700 GATOR2 complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
COPII-mediated vesicle transport
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / reaction / complex
 ENSG00000138674 O94979 / SEC31A / SEC31 homolog A, COPII coat complex component  / complex / reaction
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / complex / reaction
 ENSG00000141551 CSNK1D / P48730 / casein kinase 1 delta  / reaction
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / reaction / complex
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / complex / reaction
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / complex / reaction
 ENSG00000114745 Q9BQQ3 / GORASP1 / golgi reassembly stacking protein 1  / complex / reaction
 ENSG00000157020 SEC13 / P55735 / SEC13 homolog, nuclear pore and COPII coat complex component  / complex
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / reaction / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000114354 TFG / Q92734 / TRK-fused gene  / complex / reaction
 ENSG00000120341 Q96JE7 / SEC16B / SEC16 homolog B, endoplasmic reticulum export factor  / complex / reaction
 ENSG00000148396 O15027 / SEC16A / SEC16 homolog A, endoplasmic reticulum export factor  / complex / reaction
 ENSG00000152700 SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B  / complex / reaction
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / reaction / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction / complex
 ENSG00000107651 Q9Y6Y8 / SEC23IP / SEC23 interacting protein  / complex
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction / complex
 ENSG00000265808 O75396 / SEC22B / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / reaction / complex
 ENSG00000138069 RAB1A / P62820 / RAB1A, member RAS oncogene family  / complex / reaction
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction






 

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