ENSG00000141551


Homo sapiens

Features
Gene ID: ENSG00000141551
  
Biological name :CSNK1D
  
Synonyms : casein kinase 1 delta / CSNK1D / P48730
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q25.3
Gene start: 82239023
Gene end: 82273731
  
Corresponding Affymetrix probe sets: 207945_s_at (Human Genome U133 Plus 2.0 Array)   208774_at (Human Genome U133 Plus 2.0 Array)   213522_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463906
Ensembl peptide - ENSP00000463757
Ensembl peptide - ENSP00000464551
Ensembl peptide - ENSP00000269361
Ensembl peptide - ENSP00000324464
Ensembl peptide - ENSP00000376146
Ensembl peptide - ENSP00000381531
Ensembl peptide - ENSP00000385769
Ensembl peptide - ENSP00000462079
Ensembl peptide - ENSP00000462144
NCBI entrez gene - 1453     See in Manteia.
OMIM - 600864
RefSeq - XM_017024199
RefSeq - NM_001893
RefSeq - NM_139062
RefSeq - XM_005256336
RefSeq - XM_005256337
RefSeq Peptide - NP_001884
RefSeq Peptide - NP_620693
swissprot - J3QS70
swissprot - P48730
swissprot - B4DLF1
swissprot - H0Y2N6
swissprot - H7BYT1
swissprot - J3KRM8
swissprot - J3QQI9
swissprot - J3KRS6
swissprot - J3QQU8
Ensembl - ENSG00000141551
  
Related genetic diseases (OMIM): 615224 - Advanced sleep-phase syndrome, familial, 2, 615224
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6P3K7ENSDARG00000006125Danio rerio
 Q7T2E3ENSDARG00000008370Danio rerio
 CSNK1DENSGALG00000002719Gallus gallus
 Csnk1dENSMUSG00000025162Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Z98749.3ENSG0000028390084
CSNK1E / P49674 / casein kinase 1 epsilonENSG0000021392384
P48729 / CSNK1A1 / casein kinase 1 alpha 1ENSG0000011371256
Q8N752 / CSNK1A1L / casein kinase 1 alpha 1 likeENSG0000018013853
TTBK1 / Q5TCY1 / tau tubulin kinase 1ENSG0000014621631
TTBK2 / Q6IQ55 / tau tubulin kinase 2ENSG0000012888131


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006897 endocytosis IBA
 biological_processGO:0007020 microtubule nucleation IMP
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0034067 protein localization to Golgi apparatus IMP
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0051225 spindle assembly IDA
 biological_processGO:0061512 protein localization to cilium IMP
 biological_processGO:0071539 protein localization to centrosome IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1905426 positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation IC
 biological_processGO:1905515 non-motile cilium assembly IMP
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway ISS
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0050321 tau-protein kinase activity IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Circadian Clock
Anchoring of the basal body to the plasma membrane
Major pathway of rRNA processing in the nucleolus and cytosol
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / reaction
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / reaction
 ENSG00000138069 RAB1A / P62820 / RAB1A, member RAS oncogene family  / reaction
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / reaction
 ENSG00000114745 Q9BQQ3 / GORASP1 / golgi reassembly stacking protein 1  / reaction
 ENSG00000167110 GOLGA2 / Q08379 / golgin A2  / reaction
 ENSG00000265808 O75396 / SEC22B / SEC22 homolog B, vesicle trafficking protein (gene/pseudogene)  / reaction
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / reaction
 ENSG00000157020 SEC13 / P55735 / SEC13 homolog, nuclear pore and COPII coat complex component  / reaction
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / reaction
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / reaction
 ENSG00000107651 Q9Y6Y8 / SEC23IP / SEC23 interacting protein  / reaction
 ENSG00000138674 O94979 / SEC31A / SEC31 homolog A, COPII coat complex component  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr