ENSG00000146216


Homo sapiens

Features
Gene ID: ENSG00000146216
  
Biological name :TTBK1
  
Synonyms : Q5TCY1 / tau tubulin kinase 1 / TTBK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.1
Gene start: 43243680
Gene end: 43288259
  
Corresponding Affymetrix probe sets: 230191_at (Human Genome U133 Plus 2.0 Array)   240643_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000259750
Ensembl peptide - ENSP00000307357
NCBI entrez gene - 84630     See in Manteia.
RefSeq - XM_017011367
RefSeq - NM_032538
RefSeq - XM_017011364
RefSeq - XM_017011365
RefSeq - XM_017011366
RefSeq - XM_011514947
RefSeq Peptide - NP_115927
swissprot - Q5TCY1
swissprot - X6R456
Ensembl - ENSG00000146216
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ttbk1aENSDARG00000056019Danio rerio
 ttbk1bENSDARG00000056659Danio rerio
 TTBK1ENSGALG00000008627Gallus gallus
 Ttbk1ENSMUSG00000015599Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TTBK2 / Q6IQ55 / tau tubulin kinase 2ENSG0000012888137
CSNK1D / P48730 / casein kinase 1 deltaENSG0000014155110
Z98749.3ENSG000002839009
P48729 / CSNK1A1 / casein kinase 1 alpha 1ENSG000001137129
CSNK1E / P49674 / casein kinase 1 epsilonENSG000002139239
Q8N752 / CSNK1A1L / casein kinase 1 alpha 1 likeENSG000001801388


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011989  Armadillo-like helical
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0032091 negative regulation of protein binding IMP
 biological_processGO:0032273 positive regulation of protein polymerization IDA
 biological_processGO:0061890 positive regulation of astrocyte activation IMP
 biological_processGO:1903980 positive regulation of microglial cell activation IMP
 biological_processGO:1904031 positive regulation of cyclin-dependent protein kinase activity IMP
 biological_processGO:2001056 positive regulation of cysteine-type endopeptidase activity IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0045298 tubulin complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity NAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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