ENSG00000213923


Homo sapiens

Features
Gene ID: ENSG00000213923
  
Biological name :CSNK1E
  
Synonyms : casein kinase 1 epsilon / CSNK1E / P49674
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.1
Gene start: 38290691
Gene end: 38318084
  
Corresponding Affymetrix probe sets: 202332_at (Human Genome U133 Plus 2.0 Array)   222015_at (Human Genome U133 Plus 2.0 Array)   225756_at (Human Genome U133 Plus 2.0 Array)   226858_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403057
Ensembl peptide - ENSP00000412335
Ensembl peptide - ENSP00000412194
Ensembl peptide - ENSP00000407235
Ensembl peptide - ENSP00000403610
Ensembl peptide - ENSP00000352929
Ensembl peptide - ENSP00000380044
Ensembl peptide - ENSP00000384074
Ensembl peptide - ENSP00000384426
Ensembl peptide - ENSP00000397460
Ensembl peptide - ENSP00000400494
NCBI entrez gene - 1454     See in Manteia.
OMIM - 600863
RefSeq - NM_152221
RefSeq - NM_001894
RefSeq Peptide - NP_001885
RefSeq Peptide - NP_689407
swissprot - H0Y682
swissprot - H7C0Y5
swissprot - H7C3J2
swissprot - P49674
swissprot - B0QY36
swissprot - Q5U045
swissprot - B0QY35
swissprot - B0QY34
swissprot - H0Y5S9
swissprot - H0Y645
Ensembl - ENSG00000213923
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csnk1eENSDARG00000045150Danio rerio
 CSNK1EENSGALG00000032257Gallus gallus
 Csnk1eENSMUSG00000022433Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Z98749.3ENSG00000283900100
CSNK1D / P48730 / casein kinase 1 deltaENSG0000014155184
P48729 / CSNK1A1 / casein kinase 1 alpha 1ENSG0000011371256
Q8N752 / CSNK1A1L / casein kinase 1 alpha 1 likeENSG0000018013852
TTBK2 / Q6IQ55 / tau tubulin kinase 2ENSG0000012888130
TTBK1 / Q5TCY1 / tau tubulin kinase 1ENSG0000014621630


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006281 DNA repair TAS
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006897 endocytosis IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008360 regulation of cell shape IBA
 biological_processGO:0010389 regulation of G2/M transition of mitotic cell cycle TAS
 biological_processGO:0016055 Wnt signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IDA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0097711 ciliary basal body-plasma membrane docking TAS
 biological_processGO:1903827 regulation of cellular protein localization IDA
 biological_processGO:1905426 positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation NAS
 biological_processGO:2000052 positive regulation of non-canonical Wnt signaling pathway IC
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
WNT mediated activation of DVL
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Circadian Clock
Anchoring of the basal body to the plasma membrane
Major pathway of rRNA processing in the nucleolus and cytosol
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008405 CRY1 / Q16526 / cryptochrome circadian regulator 1  / complex
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / reaction
 ENSG00000179094 PER1 / O15534 / period circadian regulator 1  / complex
 ENSG00000133794 ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator like  / complex / reaction
 ENSG00000134852 CLOCK / O15516 / clock circadian regulator  / complex / reaction
 ENSG00000132326 PER2 / O15055 / period circadian regulator 2  / complex
 ENSG00000170485 NPAS2 / Q99743 / neuronal PAS domain protein 2  / reaction / complex
 ENSG00000121671 CRY2 / Q49AN0 / cryptochrome circadian regulator 2  / complex
 ENSG00000161202 DVL3 / Q92997 / dishevelled segment polarity protein 3  / reaction
 ENSG00000107404 DVL1 / O14640 / dishevelled segment polarity protein 1  / reaction






 

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