ENSG00000134852


Homo sapiens

Features
Gene ID: ENSG00000134852
  
Biological name :CLOCK
  
Synonyms : CLOCK / clock circadian regulator / O15516
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q12
Gene start: 55427903
Gene end: 55547138
  
Corresponding Affymetrix probe sets: 204980_at (Human Genome U133 Plus 2.0 Array)   217563_at (Human Genome U133 Plus 2.0 Array)   225856_at (Human Genome U133 Plus 2.0 Array)   227531_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426983
Ensembl peptide - ENSP00000308741
Ensembl peptide - ENSP00000370723
Ensembl peptide - ENSP00000396649
NCBI entrez gene - 9575     See in Manteia.
OMIM - 601851
RefSeq - XM_017008855
RefSeq - NM_001267843
RefSeq - NM_004898
RefSeq - XM_011534409
RefSeq - XM_011534410
RefSeq - XM_011534411
RefSeq - XM_017008854
RefSeq - XM_005265787
RefSeq Peptide - NP_001254772
RefSeq Peptide - NP_004889
swissprot - O15516
swissprot - C9JK03
Ensembl - ENSG00000134852
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clockaENSDARG00000011703Danio rerio
 clockbENSDARG00000003631Danio rerio
 CLOCKENSGALG00000013793Gallus gallus
 ClockENSMUSG00000029238Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NPAS2 / Q99743 / neuronal PAS domain protein 2ENSG0000017048549
ARNT / P27540 / aryl hydrocarbon receptor nuclear translocatorENSG0000014343719
ARNT2 / Q9HBZ2 / aryl hydrocarbon receptor nuclear translocator 2ENSG0000017237917
EPAS1 / Q99814 / endothelial PAS domain protein 1ENSG0000011601616
ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator likeENSG0000013379416
ARNTL2 / Q8WYA1 / aryl hydrocarbon receptor nuclear translocator like 2ENSG0000002915315
HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunitENSG0000010064415
SIM2 / Q14190 / single-minded family bHLH transcription factor 2ENSG0000015926313
HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunitENSG0000012444013
SIM1 / P81133 / single-minded family bHLH transcription factor 1ENSG0000011224612
NPAS3 / Q8IXF0 / neuronal PAS domain protein 3ENSG0000015132212
NPAS1 / Q99742 / neuronal PAS domain protein 1ENSG0000013075111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006473 protein acetylation IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0009648 photoperiodism TAS
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0042634 regulation of hair cycle IMP
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050796 regulation of insulin secretion ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0051775 response to redox state IDA
 biological_processGO:0071479 cellular response to ionizing radiation IDA
 biological_processGO:2000074 regulation of type B pancreatic cell development ISS
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005694 chromosome IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0033391 chromatoid body ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004402 histone acetyltransferase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0031490 chromatin DNA binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
HATs acetylate histones
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008405 CRY1 / Q16526 / cryptochrome circadian regulator 1  / reaction / complex
 ENSG00000029153 ARNTL2 / Q8WYA1 / aryl hydrocarbon receptor nuclear translocator like 2  / complex
 ENSG00000132326 PER2 / O15055 / period circadian regulator 2  / reaction / complex
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000121671 CRY2 / Q49AN0 / cryptochrome circadian regulator 2  / reaction / complex
 ENSG00000179094 PER1 / O15534 / period circadian regulator 1  / complex / reaction
 ENSG00000213923 CSNK1E / P49674 / casein kinase 1 epsilon  / complex / reaction
 ENSG00000133794 ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator like  / complex / reaction






 

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