ENSG00000159263


Homo sapiens

Features
Gene ID: ENSG00000159263
  
Biological name :SIM2
  
Synonyms : Q14190 / SIM2 / single-minded family bHLH transcription factor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: 1
Band: q22.13
Gene start: 36699133
Gene end: 36749917
  
Corresponding Affymetrix probe sets: 1557900_at (Human Genome U133 Plus 2.0 Array)   206558_at (Human Genome U133 Plus 2.0 Array)   208157_at (Human Genome U133 Plus 2.0 Array)   237923_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000290399
Ensembl peptide - ENSP00000392003
Ensembl peptide - ENSP00000476273
NCBI entrez gene - 6493     See in Manteia.
OMIM - 600892
RefSeq - XM_017028442
RefSeq - NM_005069
RefSeq - NM_009586
RefSeq - XM_011529694
RefSeq Peptide - NP_033664
RefSeq Peptide - NP_005060
swissprot - Q14190
swissprot - V9GY04
swissprot - H7BZX8
Ensembl - ENSG00000159263
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SIM2ENSGALG00000016044Gallus gallus
 Sim2ENSMUSG00000062713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SIM1 / P81133 / single-minded family bHLH transcription factor 1ENSG0000011224658
NPAS3 / Q8IXF0 / neuronal PAS domain protein 3ENSG0000015132232
HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunitENSG0000010064427
NPAS1 / Q99742 / neuronal PAS domain protein 1ENSG0000013075127
EPAS1 / Q99814 / endothelial PAS domain protein 1ENSG0000011601626
HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunitENSG0000012444024
NPAS2 / Q99743 / neuronal PAS domain protein 2ENSG0000017048517
CLOCK / O15516 / clock circadian regulatorENSG0000013485216
ARNT / P27540 / aryl hydrocarbon receptor nuclear translocatorENSG0000014343716
ARNT2 / Q9HBZ2 / aryl hydrocarbon receptor nuclear translocator 2ENSG0000017237916
ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator likeENSG0000013379416
ARNTL2 / Q8WYA1 / aryl hydrocarbon receptor nuclear translocator like 2ENSG0000002915315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001610  PAC motif
 IPR010578  Single-minded, C-terminal
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0009880 embryonic pattern specification IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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