ENSG00000133794


Homo sapiens

Features
Gene ID: ENSG00000133794
  
Biological name :ARNTL
  
Synonyms : ARNTL / aryl hydrocarbon receptor nuclear translocator like / O00327
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.3
Gene start: 13276652
Gene end: 13387266
  
Corresponding Affymetrix probe sets: 209824_s_at (Human Genome U133 Plus 2.0 Array)   210971_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385915
Ensembl peptide - ENSP00000385897
Ensembl peptide - ENSP00000431488
Ensembl peptide - ENSP00000436721
Ensembl peptide - ENSP00000436442
Ensembl peptide - ENSP00000436313
Ensembl peptide - ENSP00000434781
Ensembl peptide - ENSP00000434263
Ensembl peptide - ENSP00000434044
Ensembl peptide - ENSP00000433571
Ensembl peptide - ENSP00000433540
Ensembl peptide - ENSP00000431566
Ensembl peptide - ENSP00000374357
Ensembl peptide - ENSP00000384517
Ensembl peptide - ENSP00000385581
NCBI entrez gene - 406     See in Manteia.
OMIM - 602550
RefSeq - XM_017017748
RefSeq - NM_001030273
RefSeq - NM_001178
RefSeq - NM_001297719
RefSeq - NM_001297722
RefSeq - NM_001297724
RefSeq - NM_001351813
RefSeq - NM_001351814
RefSeq - NM_001351816
RefSeq - NM_001351822
RefSeq - XM_006718233
RefSeq - XM_006718234
RefSeq - XM_011520105
RefSeq - XM_011520107
RefSeq - XM_011520108
RefSeq - XM_011520109
RefSeq - XM_011520110
RefSeq - XM_011520111
RefSeq - XM_011520112
RefSeq - XM_011520113
RefSeq - XM_017017738
RefSeq - XM_017017739
RefSeq - XM_017017740
RefSeq - XM_017017741
RefSeq - XM_017017742
RefSeq - XM_017017743
RefSeq - XM_017017744
RefSeq - XM_017017745
RefSeq - XM_017017746
RefSeq - XM_017017747
RefSeq - NM_001030272
RefSeq Peptide - NP_001338742
RefSeq Peptide - NP_001338749
RefSeq Peptide - NP_001338750
RefSeq Peptide - NP_001338751
RefSeq Peptide - NP_001338753
RefSeq Peptide - NP_001025443
RefSeq Peptide - NP_001025444
RefSeq Peptide - NP_001169
RefSeq Peptide - NP_001284648
RefSeq Peptide - NP_001284651
RefSeq Peptide - NP_001284653
RefSeq Peptide - NP_001338733
RefSeq Peptide - NP_001338737
RefSeq Peptide - NP_001338743
RefSeq Peptide - NP_001338744
RefSeq Peptide - NP_001338745
RefSeq Peptide - NP_001338747
swissprot - E9PRB1
swissprot - E9PPV4
swissprot - E9PNI4
swissprot - E9PL54
swissprot - E9PKN1
swissprot - E9PKG7
swissprot - E9PKF0
swissprot - E9PI92
swissprot - H0YER9
swissprot - A0A140VKD3
swissprot - E9PSD2
swissprot - O00327
Ensembl - ENSG00000133794
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arntl1aENSDARG00000006791Danio rerio
 arntl1bENSDARG00000035732Danio rerio
 ARNTLENSGALG00000005378Gallus gallus
 ArntlENSMUSG00000055116Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARNTL2 / Q8WYA1 / aryl hydrocarbon receptor nuclear translocator like 2ENSG0000002915350
ARNT / P27540 / aryl hydrocarbon receptor nuclear translocatorENSG0000014343732
ARNT2 / Q9HBZ2 / aryl hydrocarbon receptor nuclear translocator 2ENSG0000017237931
CLOCK / O15516 / clock circadian regulatorENSG0000013485221
NPAS2 / Q99743 / neuronal PAS domain protein 2ENSG0000017048520
EPAS1 / Q99814 / endothelial PAS domain protein 1ENSG0000011601619
HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunitENSG0000010064418
SIM2 / Q14190 / single-minded family bHLH transcription factor 2ENSG0000015926317
NPAS3 / Q8IXF0 / neuronal PAS domain protein 3ENSG0000015132217
SIM1 / P81133 / single-minded family bHLH transcription factor 1ENSG0000011224617
NPAS1 / Q99742 / neuronal PAS domain protein 1ENSG0000013075116
HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunitENSG0000012444015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0032007 negative regulation of TOR signaling ISS
 biological_processGO:0032922 circadian regulation of gene expression ISS
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0042634 regulation of hair cycle IMP
 biological_processGO:0042753 positive regulation of circadian rhythm ISS
 biological_processGO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045599 negative regulation of fat cell differentiation ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050767 regulation of neurogenesis ISS
 biological_processGO:0050796 regulation of insulin secretion ISS
 biological_processGO:0051726 regulation of cell cycle ISS
 biological_processGO:0051775 response to redox state IDA
 biological_processGO:0060137 maternal process involved in parturition IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISS
 biological_processGO:0090403 oxidative stress-induced premature senescence ISS
 biological_processGO:1901985 positive regulation of protein acetylation IMP
 biological_processGO:2000074 regulation of type B pancreatic cell development ISS
 biological_processGO:2000323 negative regulation of glucocorticoid receptor signaling pathway ISS
 biological_processGO:2000772 regulation of cellular senescence ISS
 biological_processGO:2001016 positive regulation of skeletal muscle cell differentiation ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0033391 chromatoid body ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IGI
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IPI
 molecular_functionGO:0043425 bHLH transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0051879 Hsp90 protein binding IDA
 molecular_functionGO:0070491 repressing transcription factor binding IPI
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
Circadian Clock


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000008405 CRY1 / Q16526 / cryptochrome circadian regulator 1  / reaction / complex
 ENSG00000132326 PER2 / O15055 / period circadian regulator 2  / complex / reaction
 ENSG00000179094 PER1 / O15534 / period circadian regulator 1  / complex / reaction
 ENSG00000213923 CSNK1E / P49674 / casein kinase 1 epsilon  / complex / reaction
 ENSG00000170485 NPAS2 / Q99743 / neuronal PAS domain protein 2  / reaction / complex
 ENSG00000121671 CRY2 / Q49AN0 / cryptochrome circadian regulator 2  / reaction / complex
 ENSG00000134852 CLOCK / O15516 / clock circadian regulator  / complex / reaction






 

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