ENSG00000130751


Homo sapiens

Features
Gene ID: ENSG00000130751
  
Biological name :NPAS1
  
Synonyms : neuronal PAS domain protein 1 / NPAS1 / Q99742
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 47019820
Gene end: 47045775
  
Corresponding Affymetrix probe sets: 206699_x_at (Human Genome U133 Plus 2.0 Array)   216975_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472679
Ensembl peptide - ENSP00000469142
Ensembl peptide - ENSP00000472075
Ensembl peptide - ENSP00000398689
Ensembl peptide - ENSP00000405290
Ensembl peptide - ENSP00000468871
NCBI entrez gene - 4861     See in Manteia.
OMIM - 603346
RefSeq - XM_017026843
RefSeq - XM_011527001
RefSeq - XM_011527002
RefSeq - XM_011527006
RefSeq - XM_011527007
RefSeq - XM_017026841
RefSeq - XM_017026842
RefSeq - NM_001321086
RefSeq - NM_002517
RefSeq - XM_006723231
RefSeq - XM_011526997
RefSeq - XM_011526999
RefSeq Peptide - NP_001308015
RefSeq Peptide - NP_002508
swissprot - M0R1R8
swissprot - M0R2M8
swissprot - Q99742
swissprot - M0QX32
Ensembl - ENSG00000130751
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npas1ENSDARG00000015876Danio rerio
 Npas1ENSMUSG00000001988Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NPAS3 / Q8IXF0 / neuronal PAS domain protein 3ENSG0000015132249
SIM1 / P81133 / single-minded family bHLH transcription factor 1ENSG0000011224631
SIM2 / Q14190 / single-minded family bHLH transcription factor 2ENSG0000015926331
EPAS1 / Q99814 / endothelial PAS domain protein 1ENSG0000011601626
HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunitENSG0000010064425
HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunitENSG0000012444024
ARNT / P27540 / aryl hydrocarbon receptor nuclear translocatorENSG0000014343718
ARNTL2 / Q8WYA1 / aryl hydrocarbon receptor nuclear translocator like 2ENSG0000002915318
ARNTL / O00327 / aryl hydrocarbon receptor nuclear translocator likeENSG0000013379417
ARNT2 / Q9HBZ2 / aryl hydrocarbon receptor nuclear translocator 2ENSG0000017237917
CLOCK / O15516 / clock circadian regulatorENSG0000013485216
NPAS2 / Q99743 / neuronal PAS domain protein 2ENSG0000017048513


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001964 startle response IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0007417 central nervous system development TAS
 biological_processGO:0042711 maternal behavior IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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