ENSMUSG00000001988


Mus musculus

Features
Gene ID: ENSMUSG00000001988
  
Biological name :Npas1
  
Synonyms : Neuronal PAS domain-containing protein 1 / Npas1 / P97459
  
Possible biological names infered from orthology : neuronal PAS domain protein 1 / Q99742
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A2
Gene start: 16455721
Gene end: 16477728
  
Corresponding Affymetrix probe sets: 10560270 (MoGene1.0st)   1420801_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002053
Ensembl peptide - ENSMUSP00000147412
NCBI entrez gene - 18142     See in Manteia.
MGI - MGI:109205
RefSeq - XM_017322022
RefSeq - NM_008718
RefSeq - XM_006539614
RefSeq - XM_017322021
RefSeq Peptide - NP_032744
swissprot - A2RSH6
swissprot - P97459
Ensembl - ENSMUSG00000001988
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 npas1ENSDARG00000015876Danio rerio
 NPAS1ENSG00000130751Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Npas3 / neuronal PAS domain protein 3 / Q8IXF0*ENSMUSG0000002101049
Sim1 / Q61045 / Single-minded homolog 1 / P81133* / single-minded family bHLH transcription factor 1*ENSMUSG0000001991331
Sim2 / Q61079 / Single-minded homolog 2 / Q14190* / single-minded family bHLH transcription factor 2*ENSMUSG0000006271330
Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*ENSMUSG0000002110926
Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*ENSMUSG0000002414025
Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*ENSMUSG0000000432824
Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*ENSMUSG0000005511618
Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*ENSMUSG0000001552217
Arnt2 / Q61324 / Aryl hydrocarbon receptor nuclear translocator 2 / Q9HBZ2*ENSMUSG0000001570917
Arntl2 / Q2VPD4 / Aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSMUSG0000004018716
Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*ENSMUSG0000002923815
Npas2 / neuronal PAS domain protein 2 / Q99743*ENSMUSG0000002607712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013655  PAS fold-3
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001964 startle response IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032502 developmental process IBA
 biological_processGO:0042711 maternal behavior IGI
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
Show

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001408 stereotypic behavior "repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Npas1tm1Slm/Npas1+,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003088 abnormal prepulse inhibition "increase or decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91131]
Show

Allelic Composition: Npas1tm1Slm/Npas1tm1Slm,Npas3tm1Slm/Npas3tm1Slm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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