ENSMUSG00000015709


Mus musculus

Features
Gene ID: ENSMUSG00000015709
  
Biological name :Arnt2
  
Synonyms : Arnt2 / Aryl hydrocarbon receptor nuclear translocator 2 / Q61324
  
Possible biological names infered from orthology : Q9HBZ2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D3
Gene start: 84246278
Gene end: 84410176
  
Corresponding Affymetrix probe sets: 10565292 (MoGene1.0st)   1420669_at (Mouse Genome 430 2.0 Array)   1420670_at (Mouse Genome 430 2.0 Array)   1434028_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146414
Ensembl peptide - ENSMUSP00000147129
Ensembl peptide - ENSMUSP00000146989
Ensembl peptide - ENSMUSP00000146868
Ensembl peptide - ENSMUSP00000146781
Ensembl peptide - ENSMUSP00000146776
Ensembl peptide - ENSMUSP00000146614
Ensembl peptide - ENSMUSP00000146599
Ensembl peptide - ENSMUSP00000082154
Ensembl peptide - ENSMUSP00000146413
NCBI entrez gene - 11864     See in Manteia.
MGI - MGI:107188
RefSeq - XM_011241655
RefSeq - XM_006507244
RefSeq - XM_006507243
RefSeq - XM_006507242
RefSeq - XM_006507240
RefSeq - XM_006507239
RefSeq - XM_006507238
RefSeq - NM_007488
RefSeq Peptide - NP_031514
swissprot - Q61324
swissprot - A0A140LIW9
swissprot - A0A140LHH4
swissprot - A0A140LHY4
swissprot - A0A140LHZ6
swissprot - A0A140LID4
swissprot - A0A140LID9
swissprot - A0A140LIL3
Ensembl - ENSMUSG00000015709
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arnt2ENSDARG00000103697Danio rerio
 ARNT2ENSGALG00000006445Gallus gallus
 ARNT2ENSG00000172379Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arnt / P53762 / Aryl hydrocarbon receptor nuclear translocator / P27540*ENSMUSG0000001552265
Arntl / Q9WTL8 / Mus musculus aryl hydrocarbon receptor nuclear translocator-like (Arntl), transcript variant 3, mRNA. / O00327* / aryl hydrocarbon receptor nuclear translocator like*ENSMUSG0000005511627
Arntl2 / Q2VPD4 / Aryl hydrocarbon receptor nuclear translocator-like protein 2 / Q8WYA1* / aryl hydrocarbon receptor nuclear translocator like 2*ENSMUSG0000004018724
Clock / O08785 / Circadian locomoter output cycles protein kaput / O15516* / clock circadian regulator*ENSMUSG0000002923820
Npas2 / neuronal PAS domain protein 2 / Q99743*ENSMUSG0000002607719
Epas1 / P97481 / Endothelial PAS domain-containing protein 1 / Q99814* / endothelial PAS domain protein 1*ENSMUSG0000002414017
Npas3 / neuronal PAS domain protein 3 / Q8IXF0*ENSMUSG0000002101017
Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*ENSMUSG0000002110916
Sim1 / Q61045 / Single-minded homolog 1 / P81133* / single-minded family bHLH transcription factor 1*ENSMUSG0000001991316
Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*ENSMUSG0000000432816
Sim2 / Q61079 / Single-minded homolog 2 / Q14190* / single-minded family bHLH transcription factor 2*ENSMUSG0000006271315
Npas1 / P97459 / Neuronal PAS domain-containing protein 1 / Q99742* / neuronal PAS domain protein 1*ENSMUSG0000000198814


Protein motifs (from Interpro)
Interpro ID Name
 IPR000014  PAS domain
 IPR001067  Nuclear translocator
 IPR001610  PAC motif
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR013767  PAS fold
 IPR035965  PAS domain superfamily
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia TAS
 biological_processGO:0001701 in utero embryonic development IEP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007417 central nervous system development IMP
 biological_processGO:0007420 brain development ISS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009410 response to xenobiotic stimulus TAS
 biological_processGO:0009636 response to toxic substance TAS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Phase I - Functionalization of compounds
Endogenous sterols
Xenobiotics
Aryl hydrocarbon receptor signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0001746 abnormal pituitary secretion "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003965 abnormal pituitary hormone level "aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004164 abnormal neurophysis morphology "any malfomation or absence of the part of the pituitary gland that secretes hormones involved in blood pressure regulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0008536 enlarged third ventricle "increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008845 abnormal paraventricular hypothalamic nucleus morphology "any structural anomaly of a group of magnocellular neurons located in the periventricular zone of the anterior half of the hypothalamus" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008846 abnormal supraoptic nucleus morphology "any structural anomaly of a group of cells in the hypothalamus located over the lateral border of the optic tract; neurons produce and transport vasopressin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gabbr1tm1Pngl/Gabbr1tm1Pngl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

Allelic Composition: Arnt2tm1Yfk/Arnt2tm1Yfk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019256 Ahr / aryl hydrocarbon receptor isoform 2 / P35869* / AC019117.3* / aryl hydrocarbon receptor*  / complex / reaction
 ENSMUSG00000021575 Ahrr / aryl-hydrocarbon receptor repressor / A9YTQ3*  / reaction / complex






 

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