| MP:0000240 | extramedullary hematopoiesis | "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000274 | enlarged heart | "increase over normal size of the heart" [J:29971] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm4.1Bra/Ahrtm4.1Bra
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0000367 | abnormal coat/ hair morphology | "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000376 | folliculitis | "inflammatory reaction in hair follicles " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000405 | abnormal auchene hairs | "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000493 | rectal prolapse | "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000495 | abnormal colon morphology | "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000530 | abnormal kidney vasculature | "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
|
| MP:0000538 | abnormal urinary bladder morphology | "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Socs1tm3.1Wehi/Socs1tm3.1Wehi
Genetic Background: C57BL/6-Socs1tm3.1Wehi
|
| MP:0000540 | abnormal urinary bladder epithelium morphology | "malformation of the epithelial layer of the urinary bladder" [MGI:tc] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
|
| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0000601 | small liver | "reduced size of the liver" [J:23170] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Ahrtm4.1Bra/Ahrtm4.1Bra
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0000603 | pale liver | "liver lacking normal coloration, often refers to bloodless condition" [J:18048] |
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Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd
|
| MP:0000607 | abnormal hepatocyte morphology | "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
|
| MP:0000609 | abnormal liver physiology | "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000662 | abnormal branching of the mammary ductal tree | "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0000664 | small coagulating gland | "reduced size of the coagulating gland" [J:64981] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
|
| MP:0000689 | abnormal spleen morphology | "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000691 | enlarged spleen | "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ahrtm4.1Bra/Ahrtm4.1Bra
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0000692 | small spleen | "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001120 | abnormal uterus morphology | "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001127 | small ovary | "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0001130 | abnormal ovarian folliculogenesis | "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001154 | seminiferous tubule degeneration | "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0001191 | abnormal skin condition | "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001192 | scaly skin | "skin covered with shedding scales or flakes" [J:65146] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0001200 | thick skin | "greater depth of skin " [J:47225] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0001209 | spontaneous skin ulceration | "unpredictable appearance of skin lesions, usually with inflammation" [J:65302] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001216 | abnormal epidermal layer morphology | "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001260 | increased body weight | "greater than normal average weight " [J:33400] |
Show
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Acetm1Unc/Acetm1Unc,Ace2tm1Pngr/Ace2tm1Pngr
Genetic Background: involves: 129P2/OlaHsd
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| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra
|
| MP:0001328 | disorganized retinal layers | "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400] |
Show
Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0001573 | abnormal circulating alanine transaminase level | "aberrent concentration in the blood of this enzyme, whcih transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra
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| MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
|
| MP:0001665 | chronic diarrhea | "prolonged diarrhea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001790 | abnormal immune system physiology | "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ahrb-1/Ahrb-1
Genetic Background: C57BL/6J
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| MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrb-1/Ahrb-1
Genetic Background: C57BL/6J
|
| MP:0001853 | heart inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001855 | atrial thrombosis | "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
Show
Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0001874 | acanthosis | "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0001928 | abnormal ovulation | "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0002209 | germ cell depletion | "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0002356 | abnormal spleen red pulp morphology | "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
|
| MP:0002451 | abnormal macrophage physiology | "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ahrtm4.1Bra/Ahrtm4.1Bra
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0002662 | abnormal cauda | "anomalous structure of the tail of the epididymis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
|
| MP:0002680 | decreased number of corpora lutea | "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
|
| MP:0002816 | colitis | "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
|
| MP:0002833 | increased heart weight | "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm2Bra/Ahrtm2Bra
Genetic Background: involves: 129/Sv * C57BL/6
|
| MP:0002975 | vascular smooth muscle hypertrophy | "increase in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0003009 | abnormal cytokine secretion | "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003141 | cardiac fibrosis | "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0003254 | bile duct inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the bile ducts" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0003299 | gastric polyps | "abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the colon" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0003324 | liver adenoma | "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0003333 | liver fibrosis | "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0003402 | decreased liver weight | "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ahrtm2Bra/Ahrtm2Bra
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
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| MP:0003453 | abnormal keratinocyte physiology | "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0003507 | abnormal ovary physiology | "anomaly or loss either the production of female germ cells or the endocrine cells for the production of estrogen and progesterone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra/J
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| MP:0003809 | abnormal hair shaft morphology | "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0003828 | pulmonary edema | "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra/J
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| MP:0004004 | patent ductus venosus | "failure of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein (that allows oxygenated blood to bypass the developing liver) to close in adults" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ahrtm2Bra/Ahrtm2Bra
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Ahrtm3Bra/Ahrtm3Bra
Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2
Allelic Composition: Ahrtm3.1Bra/Ahrtm3.1Bra,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Ahrtm3.1Bra Tg(Tek-cre)12Flv
Allelic Composition: Ahrtm4.1Bra/Ahrtm4.1Bra
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra
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| MP:0004111 | abnormal coronary artery morphology | "anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0004182 | abnormal spermiation | "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0004499 | increased incidence of chemically-induced tumors | "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Card11tm1Xav/Card11tm1Xav
Genetic Background: involves: 129 * C57BL/6
Allelic Composition: Ahrd/Ahrd
Genetic Background: involves: 129S1/SvImJ * C57BL/6J
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| MP:0004852 | decreased testis weight | "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0004856 | decreased ovary weight | "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0004910 | decreased seminal gland weight | "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
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| MP:0004929 | decreased epididymis weight | "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0004952 | increased spleen weight | "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm2Bra/Ahrtm2Bra
Genetic Background: involves: 129/Sv * C57BL/6
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| MP:0005048 | thrombosis | "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0005141 | liver hyperplasia | "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005165 | increased susceptibility to injury | "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0005362 | abnormal Langerhans cell physiology | "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0005418 | abnormal circulating hormone level | "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
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| MP:0005578 | teratozoospermia | "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Spp1tm1Blh/Spp1tm1Blh
Genetic Background: involves: 129S6/SvEvTac * C57BL/6
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| MP:0005616 | decreased susceptibility to type IV hypersensitivity reaction | "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0008117 | abnormal Langerhans cell morphology | "any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus" [CL:0000453, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0008280 | male germ cell apoptosis | "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0008479 | decreased spleen white pulp amount | "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0008484 | decreased spleen germinal center size | "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0008713 | abnormal cytokine level | "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra/J
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| MP:0008721 | abnormal chemokine level | "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra/J
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| MP:0008751 | abnormal interleukin level | "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra/J
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| MP:0008752 | abnormal tumor necrosis factor level | "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra/J
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
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| MP:0008873 | increased sensitivity to xenobiotics | "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrb-1/Ahrb-1
Genetic Background: C57BL/6J
Allelic Composition: Ahrb-1/Ahrb-1
Genetic Background: C58/J
Allelic Composition: Ahrb-2/Ahrb-2
Genetic Background: C3H/He
Allelic Composition: Ahrb-2/Ahrb-2
Genetic Background: A/He
Allelic Composition: Ahrb-1/Ahrd
Genetic Background: involves: 129S1/SvImJ * C57BL/6J
Allelic Composition: Ahrd/Ahrd
Genetic Background: involves: 129S1/SvImJ * C57BL/6J
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra/J
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| MP:0008874 | decreased sensitivity to xenobiotics | "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ahrtm2Bra/Ahrtm2Bra
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Ahrtm3Bra/Ahrtm3Bra
Genetic Background: involves: 129/Sv * C57BL/6J * DBA/2
Allelic Composition: Ahrtm3.1Bra/Ahrtm3.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Ahrtm3.1Bra Speer6-ps1Tg(Alb-cre)21Mgn
Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Ahrtm1(AHR)Mym/Ahrtm1(AHR)Mym
Genetic Background: B6.129P2-Ahrtm1(AHR)Mym
Allelic Composition: Ahrd/Ahrd
Genetic Background: DBA/2J
Allelic Composition: Ahrd/Ahrd
Genetic Background: AKR
Allelic Composition: Ahrd/Ahrd
Genetic Background: B6.D2-Ahrd
Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J
Allelic Composition: Ahrtm4.1Bra/Ahrtm4.1Bra
Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
Allelic Composition: Ahrb-1/Ahrb-1,Aiptm2.1Bra/Aiptm2.1Bra,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Speer6-ps1Tg(Alb-cre)21Mgn Aiptm2.1Bra
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| MP:0008875 | abnormal pharmacokinetics of xenobiotics | "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * ICR
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| MP:0008989 | abnormal liver sinusoid morphology | "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
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| MP:0009230 | abnormal sperm head morphology | "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0009238 | coiled sperm flagellum | "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0009361 | abnormal primordial ovarian follicle morphology | "any structural abnormality in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra/J
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| MP:0009550 | urinary bladder carcinoma | "a malignant neoplasm of the urinary bladder, arising from epithelial cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0009600 | hypergranulosis | "increased thickness of the granular layer of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0009619 | abnormal optokinetic reflex | "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement; normally, this reflex functions to stabilize a moving image on the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0009646 | urinary bladder inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0009647 | decreased fertilization frequency | "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0009648 | abnormal superovulation | "impaired ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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| MP:0009740 | small prostate gland dorsolateral lobe | "reduced size of the rodent prostate lobe that lies in the triangular area between urethra and seminal vesicle" [PMID:12645922, PMID:3308446] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
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| MP:0009766 | increased sensitivity to xenobiotic induced morbidity/mortality | "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrb-1/Ahrb-1
Genetic Background: C57BL/6J
Allelic Composition: Ahrb-1/Ahrb-1
Genetic Background: C58/J
Allelic Composition: Ahrb-2/Ahrb-2
Genetic Background: C3H/He
Allelic Composition: Ahrb-2/Ahrb-2
Genetic Background: A/He
Allelic Composition: Ahrb-1/Ahrd
Genetic Background: involves: 129S1/SvImJ * C57BL/6J
Allelic Composition: Ahrd/Ahrd
Genetic Background: involves: 129S1/SvImJ * C57BL/6J
Allelic Composition: Ahrb-1/Ahrd
Genetic Background: involves: C57BL/6 * DBA/2
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| MP:0009767 | decreased sensitivity to xenobiotic induced morbidity/mortality | "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrd/Ahrd
Genetic Background: DBA/2J
Allelic Composition: Ahrd/Ahrd
Genetic Background: AKR
Allelic Composition: Ahrd/Ahrd
Genetic Background: B6.D2-Ahrd
Allelic Composition: Ahrtm1Gonz/Ahrtm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6J
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| MP:0009810 | increased urine uric acid level | "greater concentration in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0010264 | increased hepatoma incidence | "greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0010357 | increased prostate gland tumor incidence | "greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
Allelic Composition: Ahrtm1Bra/Ahr+,Tg(TRAMP)8247Ng/0
Genetic Background: B6.Cg-Ahrtm1Bra Tg(TRAMP)8247Ng
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| MP:0010785 | abnormal stomach pyloric region morphology | "any structural anomaly of the stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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| MP:0010894 | pulmonary alveolar edema | "an effusion of serous fluid into the pulmonary alveoli; usually caused by the movement of blood components through the pulmonary capillary walls as a result of a change in osmotic pressure, an increased permeability of the walls, or related factors" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra/J
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| MP:0011042 | abnormal horizontal vestibuloocular reflex | "any anomaly in the nystagmus or deviation of the eyes in response to stimulation along the horizontal axis of the vestibular system" [MGI:smb] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * ICR
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| MP:0011625 | cystolithiasis | "caliculi, or a solid concretion or crystal aggregation, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection" [MGI:csmith] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0011750 | abnormal seminiferous tubule epithelium morphology | "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0011769 | urinary bladder fibrosis | "invasion of fibrous connective tissue into the urinary bladder, often resulting from inflammation or injury" [MGI:anna] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0011773 | abnormal urinary bladder blood vessel morphology | "any structural anomaly of the network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys" [MGI:anna] |
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Allelic Composition: Ahrtm1Yfk/Ahrtm1Yfk
Genetic Background: involves: 129S/SvEv * C57BL/6J
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| MP:0012538 | persistent hyaloid artery | "incomplete regression of the hyaloid artery, usually accompanied by persistence of the hyperplastic primary vitreous; small remnants of the artery may remain with free remnants sometimes seen as floating material (aka muscae volitantes); an anterior remnant of the hyaloid artery can be seen as Mittendorf s dot, a small pinpoint-like scar on the posterior surface of the lens; a posterior remnant may be seen where the artery left the optic disc, and is known as Bergmeister s papilla" [MGI:anna] |
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Allelic Composition: Ahrtm1Bra/Ahrtm1Bra
Genetic Background: B6.129-Ahrtm1Bra
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| MP:0020550 | multinucleated giant male germ cells | "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm] |
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Allelic Composition: Adam17tm1.1Wesh/Adam17tm1.1Wesh,Tg(Scgb1a1-rtTA)2Jaw/0,Tg(tetO-cre)1Jaw/0,Twist2tm1.1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
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| MP:0030571 | dilated piliary canal | "stretched or widened aperture of the luminal space of the tubular connection that is found between the epidermal surface and the most distal part of the hair follicle inner root sheath and contains the hair shaft; the infundibulum is the opening of the hair canal to the skin surface" [MGI:anna, PMID:11171393] |
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Allelic Composition: Tal1tm3Wehi/Tal1tm2Wehi,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA
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