ENSMUSG00000071072


Mus musculus

Features
Gene ID: ENSMUSG00000071072
  
Biological name :Ptges3
  
Synonyms : Prostaglandin E synthase 3 / Ptges3 / Q9R0Q7
  
Possible biological names infered from orthology : Q15185
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128058954
Gene end: 128077272
  
Corresponding Affymetrix probe sets: 10367100 (MoGene1.0st)   10511865 (MoGene1.0st)   10539649 (MoGene1.0st)   1417998_at (Mouse Genome 430 2.0 Array)   1460221_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081827
Ensembl peptide - ENSMUSP00000050292
NCBI entrez gene - 56351     See in Manteia.
MGI - MGI:1929282
RefSeq - NM_019766
RefSeq Peptide - NP_062740
swissprot - D3Z7C6
swissprot - Q9R0Q7
Ensembl - ENSMUSG00000071072
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptges3aENSDARG00000037284Danio rerio
 ptges3bENSDARG00000089626Danio rerio
 PTGES3ENSGALG00000036837Gallus gallus
 PTGES3ENSG00000110958Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm27029 / PTGES3L-AARSD1 readthrough / Q9BTE6* / PTGES3L-AARSD1*ENSMUSG0000009723943
Q9D9A7 / Ptges3l / Putative protein PTGES3L / prostaglandin E synthase 3 like*ENSMUSG0000009748736
Aarsd1 / Q3THG9 / alanyl-tRNA synthetase domain containing 1 / Q9BTE6*ENSMUSG0000007552811


Protein motifs (from Interpro)
Interpro ID Name
 IPR007052  CS domain
 IPR008978  HSP20-like chaperone


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process ISO
 biological_processGO:0005978 glycogen biosynthetic process IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0007004 telomere maintenance via telomerase IDA
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0042327 positive regulation of phosphorylation ISO
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IMP
 biological_processGO:0043588 skin development IMP
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding ISO
 biological_processGO:0051131 chaperone-mediated protein complex assembly ISO
 biological_processGO:0051973 positive regulation of telomerase activity IDA
 biological_processGO:0060430 lung saccule development IMP
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:1905323 telomerase holoenzyme complex assembly IDA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005697 telomerase holoenzyme complex ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005884 actin filament IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003720 telomerase activity ISO
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0050220 prostaglandin-E synthase activity ISO
 molecular_functionGO:0051082 unfolded protein binding ISS
 molecular_functionGO:0051879 Hsp90 protein binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IPI


Pathways (from Reactome)
Pathway description
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
Aryl hydrocarbon receptor signalling
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001196 shiny skin "skin with a glossy or glistening appearance" [J:56641]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009931 abnormal skin appearance "skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010811 decreased type II pneumocyte number "reduced number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010887 pale lung "lung lacking normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gria2tm3Rsp/Gria2tm3Rsp,Tg(Camk2a-cre)1Gsc/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * FVB/N

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Ptges3tm1Nkt/Ptges3tm1Nkt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015656 Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*  / reaction
 ENSMUSG00000024847 Aip / O08915 / AH receptor-interacting protein / O00170* / aryl hydrocarbon receptor interacting protein*  / complex
 ENSMUSG00000023944 P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / reaction / complex
 ENSMUSG00000024966 Stip1 / Q60864 / Stress-induced-phosphoprotein 1 / P31948*  / reaction
 ENSMUSG00000030357 Fkbp4 / P30416 / Peptidyl-prolyl cis-trans isomerase FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed / Q02790* / FK506 binding protein 4*  / complex / reaction
 ENSMUSG00000027804 Ppid / Q9CR16 / peptidylprolyl isomerase D (cyclophilin D) / Q08752* / peptidylprolyl isomerase D*  / complex
 ENSMUSG00000046532 Ar / P19091 / Androgen receptor / P10275*  / complex
 ENSMUSG00000090877 P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction
 ENSMUSG00000031870 Pgr / Q00175 / Progesterone receptor / P06401*  / complex
 ENSMUSG00000022556 Hsf1 / P38532 / heat shock factor 1 / Q00613* / heat shock transcription factor 1*  / reaction / complex
 ENSMUSG00000019256 Ahr / aryl hydrocarbon receptor isoform 2 / P35869* / AC019117.3* / aryl hydrocarbon receptor*  / complex
 ENSMUSG00000091971 Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*  / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex
 ENSMUSG00000071072 Ptges3 / Q9R0Q7 / Prostaglandin E synthase 3 / Q15185*  / complex / reaction
 ENSMUSG00000021055 Esr2 / O08537 / Estrogen receptor beta / Q92731* / estrogen receptor 2*  / complex
 ENSMUSG00000024222 Fkbp5 / Q64378 / Peptidyl-prolyl cis-trans isomerase FKBP5 / Q13451* / FK506 binding protein 5*  / complex / reaction






 

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