ENSG00000110958


Homo sapiens

Features
Gene ID: ENSG00000110958
  
Biological name :PTGES3
  
Synonyms : prostaglandin E synthase 3 / PTGES3 / Q15185
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.3
Gene start: 56663341
Gene end: 56688408
  
Corresponding Affymetrix probe sets: 200627_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000402385
Ensembl peptide - ENSP00000389090
Ensembl peptide - ENSP00000405299
Ensembl peptide - ENSP00000482075
Ensembl peptide - ENSP00000414892
Ensembl peptide - ENSP00000262033
NCBI entrez gene - 10728     See in Manteia.
OMIM - 607061
RefSeq - XM_011537774
RefSeq - NM_001282601
RefSeq - NM_001282602
RefSeq - NM_001282603
RefSeq - NM_001282604
RefSeq - NM_001282605
RefSeq - NM_006601
RefSeq - XM_005268576
RefSeq - XM_006719199
RefSeq - XM_011537773
RefSeq Peptide - NP_001269530
RefSeq Peptide - NP_001269533
RefSeq Peptide - NP_001269534
RefSeq Peptide - NP_006592
RefSeq Peptide - NP_001269531
RefSeq Peptide - NP_001269532
swissprot - B4DDC6
swissprot - A0A087WYT3
swissprot - Q15185
swissprot - A0A024RB32
Ensembl - ENSG00000110958
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptges3aENSDARG00000037284Danio rerio
 ptges3bENSDARG00000089626Danio rerio
 PTGES3ENSGALG00000036837Gallus gallus
 Ptges3ENSMUSG00000071072Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9BTE6 / PTGES3L-AARSD1 / PTGES3L-AARSD1 readthroughENSG0000010882540
PTGES3L / prostaglandin E synthase 3 likeENSG0000026706024
AARSD1 / Q9BTE6 / alanyl-tRNA synthetase domain containing 1ENSG000002669679


Protein motifs (from Interpro)
Interpro ID Name
 IPR007052  CS domain
 IPR008978  HSP20-like chaperone


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000723 telomere maintenance TAS
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0005978 glycogen biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006633 fatty acid biosynthetic process IEA
 biological_processGO:0006693 prostaglandin metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0007004 telomere maintenance via telomerase IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0019371 cyclooxygenase pathway TAS
 biological_processGO:0042327 positive regulation of phosphorylation IDA
 biological_processGO:0042921 glucocorticoid receptor signaling pathway IEA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051085 chaperone cofactor-dependent protein refolding IDA
 biological_processGO:0051131 chaperone-mediated protein complex assembly IMP
 biological_processGO:0051973 positive regulation of telomerase activity IEA
 biological_processGO:0060430 lung saccule development IEA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1905323 telomerase holoenzyme complex assembly IEA
 cellular_componentGO:0000781 chromosome, telomeric region IC
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005697 telomerase holoenzyme complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0032991 protein-containing complex IMP
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003720 telomerase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0050220 prostaglandin-E synthase activity TAS
 molecular_functionGO:0051082 unfolded protein binding IDA
 molecular_functionGO:0051879 Hsp90 protein binding IPI
 molecular_functionGO:0070182 DNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
HSP90 chaperone cycle for steroid hormone receptors (SHR)
HSF1 activation
Attenuation phase
Aryl hydrocarbon receptor signalling
ESR-mediated signaling
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004478 FKBP4 / Q02790 / FK506 binding protein 4  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / reaction
 ENSG00000106546 AHR / P35869 / aryl hydrocarbon receptor  / complex
 ENSG00000113580 NR3C1 / P04150 / nuclear receptor subfamily 3 group C member 1  / complex
 ENSG00000082175 PGR / P06401 / progesterone receptor  / complex
 ENSG00000171497 PPID / Q08752 / peptidylprolyl isomerase D  / complex
 ENSG00000204388 HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1B  / reaction
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / complex / reaction
 ENSG00000151623 NR3C2 / P08235 / nuclear receptor subfamily 3 group C member 2  / complex
 ENSG00000204389 HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1A  / reaction
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / reaction / complex
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / reaction
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / reaction / complex
 ENSG00000096060 FKBP5 / Q13451 / FK506 binding protein 5  / reaction / complex
 ENSG00000169083 AR / P10275 / androgen receptor  / complex
 ENSG00000140009 ESR2 / Q92731 / estrogen receptor 2  / complex
 ENSG00000110711 AIP / O00170 / aryl hydrocarbon receptor interacting protein  / complex






 

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