ENSG00000204389


Homo sapiens

Features
Gene ID: ENSG00000204389
  
Biological name :HSPA1A
  
Synonyms : heat shock protein family A (Hsp70) member 1A / HSPA1A / P0DMV8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.33
Gene start: 31815464
Gene end: 31817946
  
Corresponding Affymetrix probe sets: 200799_at (Human Genome U133 Plus 2.0 Array)   200800_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364802
Ensembl peptide - ENSP00000477378
NCBI entrez gene - 3303     See in Manteia.
OMIM - 140550
RefSeq - NM_005345
RefSeq Peptide - NP_005336
swissprot - A8K5I0
swissprot - P0DMV8
swissprot - V9GZ37
Ensembl - ENSG00000204389
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Hspa1aENSMUSG00000091971Mus musculus
 Hspa1bENSMUSG00000090877Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1BENSG00000204388100
HSPA1L / P34931 / heat shock protein family A (Hsp70) member 1 likeENSG0000020439089
HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8ENSG0000010997186
HSPA2 / P54652 / heat shock protein family A (Hsp70) member 2ENSG0000012680384
HSPA6 / P17066 / heat shock protein family A (Hsp70) member 6ENSG0000017311082
HSPA5 / P11021 / heat shock protein family A (Hsp70) member 5ENSG0000004457462
HSPA14 / Q0VDF9 / heat shock protein family A (Hsp70) member 14ENSG0000018752227
HSPA14 / heat shock protein family A (Hsp70) member 14ENSG000002840247


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006402 mRNA catabolic process IDA
 biological_processGO:0006986 response to unfolded protein IDA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0031396 regulation of protein ubiquitination IDA
 biological_processGO:0031397 negative regulation of protein ubiquitination IDA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IMP
 biological_processGO:0034599 cellular response to oxidative stress TAS
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0042026 protein refolding IMP
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0046034 ATP metabolic process IDA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051131 chaperone-mediated protein complex assembly IDA
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0070370 cellular heat acclimation IMP
 biological_processGO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
 biological_processGO:0090063 positive regulation of microtubule nucleation IMP
 biological_processGO:0090084 negative regulation of inclusion body assembly IDA
 biological_processGO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress IDA
 biological_processGO:1900034 regulation of cellular response to heat TAS
 biological_processGO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
 biological_processGO:1901673 regulation of mitotic spindle assembly IMP
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
 biological_processGO:1902380 positive regulation of endoribonuclease activity IDA
 biological_processGO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway IMP
 biological_processGO:1904722 obsolete positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response IDA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005814 centriole IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0008180 COP9 signalosome IDA
 cellular_componentGO:0016234 inclusion body IDA
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031072 heat shock protein binding IPI
 molecular_functionGO:0031249 denatured protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042623 ATPase activity, coupled TAS
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0044183 protein binding involved in protein folding IDA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0051082 unfolded protein binding NAS
 molecular_functionGO:0055131 C3HC4-type RING finger domain binding IPI
 molecular_functionGO:0097718 disordered domain specific binding IPI


Pathways (from Reactome)
Pathway description
Viral RNP Complexes in the Host Cell Nucleus
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000096717 SIRT1 / Q96EB6 / sirtuin 1  / reaction / complex
 ENSG00000132002 DNAJB1 / P25685 / DnaJ heat shock protein family (Hsp40) member B1  / reaction / complex
 ENSG00000105821 DNAJC2 / Q99543 / DnaJ heat shock protein family (Hsp40) member C2  / reaction
 ENSG00000105993 DNAJB6 / O75190 / DnaJ heat shock protein family (Hsp40) member B6  / reaction
 ENSG00000110958 PTGES3 / Q15185 / prostaglandin E synthase 3  / reaction
 ENSG00000005339 CREBBP / Q92793 / CREB binding protein  / reaction
 ENSG00000100393 EP300 / Q09472 / E1A binding protein p300  / reaction
 ENSG00000149196 Q53FT3 / HIKESHI / Hikeshi, heat shock protein nuclear import factor  / reaction / complex
 ENSG00000168439 STIP1 / P31948 / stress induced phosphoprotein 1  / complex / reaction
 ENSG00000069345 DNAJA2 / O60884 / DnaJ heat shock protein family (Hsp40) member A2  / complex / reaction
 ENSG00000168259 DNAJC7 / Q99615 / DnaJ heat shock protein family (Hsp40) member C7  / reaction
 ENSG00000086061 DNAJA1 / P31689 / DnaJ heat shock protein family (Hsp40) member A1  / complex / reaction
 ENSG00000140403 DNAJA4 / Q8WW22 / DnaJ heat shock protein family (Hsp40) member A4  / reaction / complex
 ENSG00000120694 HSPH1 / Q92598 / heat shock protein family H (Hsp110) member 1  / reaction
 ENSG00000096060 FKBP5 / Q13451 / FK506 binding protein 5  / complex / reaction
 ENSG00000080824 P07900 / HSP90AA1 / heat shock protein 90 alpha family class A member 1  / reaction / complex
 ENSG00000004478 FKBP4 / Q02790 / FK506 binding protein 4  / reaction / complex
 ENSG00000096384 P08238 / HSP90AB1 / heat shock protein 90 alpha family class B member 1  / complex / reaction
 ENSG00000185122 HSF1 / Q00613 / heat shock transcription factor 1  / complex / reaction






 

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