ENSG00000126803


Homo sapiens

Features
Gene ID: ENSG00000126803
  
Biological name :HSPA2
  
Synonyms : heat shock protein family A (Hsp70) member 2 / HSPA2 / P54652
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q23.3
Gene start: 64535905
Gene end: 64546173
  
Corresponding Affymetrix probe sets: 211538_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000247207
Ensembl peptide - ENSP00000378199
NCBI entrez gene - 3306     See in Manteia.
OMIM - 140560
RefSeq - NM_021979
RefSeq Peptide - NP_068814
swissprot - A0A024R6B5
swissprot - P54652
Ensembl - ENSG00000126803
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HSPA2ENSGALG00000011715Gallus gallus
 Hspa2ENSMUSG00000059970Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8ENSG0000010997187
HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1BENSG0000020438884
HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1AENSG0000020438984
HSPA1L / P34931 / heat shock protein family A (Hsp70) member 1 likeENSG0000020439082
HSPA6 / P17066 / heat shock protein family A (Hsp70) member 6ENSG0000017311079
HSPA5 / P11021 / heat shock protein family A (Hsp70) member 5ENSG0000004457463
HSPA14 / Q0VDF9 / heat shock protein family A (Hsp70) member 14ENSG0000018752228
HSPA14 / heat shock protein family A (Hsp70) member 14ENSG000002840247


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006986 response to unfolded protein TAS
 biological_processGO:0007140 male meiotic nuclear division TAS
 biological_processGO:0007141 male meiosis I IEA
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0007286 spermatid development TAS
 biological_processGO:0009408 response to heat ISS
 biological_processGO:0009409 response to cold ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032781 positive regulation of ATPase activity IEA
 biological_processGO:0042026 protein refolding IDA
 biological_processGO:0070194 synaptonemal complex disassembly IEA
 biological_processGO:0090084 negative regulation of inclusion body assembly IDA
 biological_processGO:1901896 positive regulation of calcium-transporting ATPase activity IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0001673 male germ cell nucleus IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0036128 CatSper complex ISS
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 cellular_componentGO:0072687 meiotic spindle ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0051082 unfolded protein binding TAS
 molecular_functionGO:0051861 glycolipid binding IEA
 molecular_functionGO:0097718 disordered domain specific binding IPI


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr