ENSG00000044574


Homo sapiens

Features
Gene ID: ENSG00000044574
  
Biological name :HSPA5
  
Synonyms : heat shock protein family A (Hsp70) member 5 / HSPA5 / P11021
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: q33.3
Gene start: 125234853
Gene end: 125241330
  
Corresponding Affymetrix probe sets: 211936_at (Human Genome U133 Plus 2.0 Array)   230031_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000324173
NCBI entrez gene - 3309     See in Manteia.
OMIM - 138120
RefSeq - NM_005347
RefSeq Peptide - NP_005338
swissprot - P11021
swissprot - V9HWB4
Ensembl - ENSG00000044574
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspa5ENSDARG00000103846Danio rerio
 ENSGALG00000033498Gallus gallus
 HSPA5ENSGALG00000001000Gallus gallus
 Hspa5ENSMUSG00000026864Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8ENSG0000010997163
HSPA1L / P34931 / heat shock protein family A (Hsp70) member 1 likeENSG0000020439061
HSPA2 / P54652 / heat shock protein family A (Hsp70) member 2ENSG0000012680361
HSPA1A / P0DMV8 / heat shock protein family A (Hsp70) member 1AENSG0000020438961
HSPA1B / P0DMV9 / heat shock protein family A (Hsp70) member 1BENSG0000020438861
HSPA6 / P17066 / heat shock protein family A (Hsp70) member 6ENSG0000017311060
HSPA14 / Q0VDF9 / heat shock protein family A (Hsp70) member 14ENSG0000018752226
HSPA14 / heat shock protein family A (Hsp70) member 14ENSG000002840247


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006983 ER overload response IEA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0021589 cerebellum structural organization IEA
 biological_processGO:0021680 cerebellar Purkinje cell layer development IEA
 biological_processGO:0021762 substantia nigra development HEP
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway TAS
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response TAS
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0034975 protein folding in endoplasmic reticulum TAS
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035437 maintenance of protein localization in endoplasmic reticulum IMP
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0036499 PERK-mediated unfolded protein response TAS
 biological_processGO:0036500 ATF6-mediated unfolded protein response TAS
 biological_processGO:0042149 cellular response to glucose starvation IDA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0060904 regulation of protein folding in endoplasmic reticulum TAS
 biological_processGO:0071236 cellular response to antibiotic IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071287 cellular response to manganese ion IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071353 cellular response to interleukin-4 IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0090074 negative regulation of protein homodimerization activity TAS
 biological_processGO:0097501 stress response to metal ion IEA
 biological_processGO:1901998 toxin transport IEA
 biological_processGO:1903891 regulation of ATF6-mediated unfolded protein response TAS
 biological_processGO:1903894 regulation of IRE1-mediated unfolded protein response TAS
 biological_processGO:1903895 negative regulation of IRE1-mediated unfolded protein response ISS
 biological_processGO:1903897 regulation of PERK-mediated unfolded protein response TAS
 biological_processGO:1904313 response to methamphetamine hydrochloride IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress TAS
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0008180 COP9 signalosome IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0051087 chaperone binding TAS
 molecular_functionGO:0051787 misfolded protein binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000172071 Q9NZJ5 / EIF2AK3 / eukaryotic translation initiation factor 2 alpha kinase 3  / complex
 ENSG00000118217 ATF6 / P18850 / activating transcription factor 6  / complex
 ENSG00000178607 ERN1 / O75460 / endoplasmic reticulum to nucleus signaling 1  / complex






 

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