ENSMUSG00000026864


Mus musculus

Features
Gene ID: ENSMUSG00000026864
  
Biological name :Hspa5
  
Synonyms : heat shock protein 5 / Hspa5 / P20029
  
Possible biological names infered from orthology : heat shock protein family A (Hsp70) member 5 / P11021
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 34771970
Gene end: 34777547
  
Corresponding Affymetrix probe sets: 10471586 (MoGene1.0st)   1416064_a_at (Mouse Genome 430 2.0 Array)   1427464_s_at (Mouse Genome 430 2.0 Array)   1447824_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141966
Ensembl peptide - ENSMUSP00000028222
Ensembl peptide - ENSMUSP00000097747
NCBI entrez gene - 14828     See in Manteia.
MGI - MGI:95835
RefSeq - NM_001163434
RefSeq - NM_022310
RefSeq Peptide - NP_001156906
RefSeq Peptide - NP_071705
swissprot - A0A0A6YXF5
swissprot - P20029
Ensembl - ENSMUSG00000026864
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspa5ENSDARG00000103846Danio rerio
 ENSGALG00000033498Gallus gallus
 HSPA5ENSGALG00000001000Gallus gallus
 HSPA5ENSG00000044574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hspa8 / P63017 / Heat shock cognate 71 kDa protein / P11142* / heat shock protein family A (Hsp70) member 8*ENSMUSG0000001565663
Hspa2 / P17156 / Heat shock-related 70 kDa protein 2 / P54652* / heat shock protein family A (Hsp70) member 2*ENSMUSG0000005997061
P17879 / Hspa1b / Heat shock 70 kDa protein 1B / HSPA1A* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*ENSMUSG0000009087760
Q61696 / Hspa1a / Heat shock 70 kDa protein 1A / HSPA1B* / P0DMV8* / P0DMV9* / heat shock protein family A (Hsp70) member 1B* / heat shock protein family A (Hsp70) member 1A*ENSMUSG0000009197160
Hspa1l / P16627 / Heat shock 70 kDa protein 1-like / P34931* / heat shock protein family A (Hsp70) member 1 like*ENSMUSG0000000703360
Hspa14 / Q99M31 / Heat shock 70 kDa protein 14 / Q0VDF9* / heat shock protein family A (Hsp70) member 14*ENSMUSG0000010986525


Protein motifs (from Interpro)
Interpro ID Name
 IPR013126  Heat shock protein 70 family
 IPR018181  Heat shock protein 70, conserved site
 IPR029047  Heat shock protein 70kD, peptide-binding domain superfamily
 IPR029048  Heat shock protein 70kD, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006983 ER overload response IDA
 biological_processGO:0006987 obsolete activation of signaling protein activity involved in unfolded protein response IMP
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0021589 cerebellum structural organization IMP
 biological_processGO:0021680 cerebellar Purkinje cell layer development IMP
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IGI
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress ISO
 biological_processGO:0035437 maintenance of protein localization in endoplasmic reticulum ISO
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0040019 positive regulation of embryonic development TAS
 biological_processGO:0042149 cellular response to glucose starvation ISO
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IDA
 biological_processGO:0071236 cellular response to antibiotic IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071287 cellular response to manganese ion IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0090074 negative regulation of protein homodimerization activity ISS
 biological_processGO:0097501 stress response to metal ion IEA
 biological_processGO:1901998 toxin transport IMP
 biological_processGO:1903895 negative regulation of IRE1-mediated unfolded protein response ISS
 biological_processGO:1904313 response to methamphetamine hydrochloride IEA
 biological_processGO:1990090 cellular response to nerve growth factor stimulus IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005788 endoplasmic reticulum lumen IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment ISO
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0008180 COP9 signalosome ISO
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISO
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex ISO
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0043022 ribosome binding IDA
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0051082 unfolded protein binding IEA
 molecular_functionGO:0051787 misfolded protein binding IDA


Pathways (from Reactome)
Pathway description
Regulation of HSF1-mediated heat shock response
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Trip11m1Mawa/Trip11m1Mawa,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nlrp3m5Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3m5Btlr

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nlrp3m5Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3m5Btlr

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Nlrp3m5Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3m5Btlr

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Nlrp3m5Btlr/Nlrp3+
Genetic Background: C57BL/6J-Nlrp3m5Btlr

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kmt2atm1Saam/Kmt2a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3Sp-2H/Pax3+
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax3Sp-2H/Pax3+
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Pax3Sp-2H/Pax3+
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hiratm1Pjs/Hiratm1Pjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hiratm1Pjs/Hiratm1Pjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pax3Sp-2H/Pax3+
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0008457 abnormal cortical intermediate zone morphology "any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599]
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Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0008817 hematoma "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

 MP:0009219 prostate intraepithelial neoplasia "noninvasive prostate duct lesions that affect smaller caliber ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009220 prostate adenocarcinoma "malignant neoplasm arising from prostate tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hspa5tm1Alee/Hspa5+,Ptentm1Hwu/Ptentm1Hwu,Tg(Pbsn-cre)4Prb/?
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6 * DBA/2

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0009687 empty decidua capsularis "the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hiratm1Pjs/Hiratm1Pjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hiratm1Pjs/Hiratm1Pjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0010813 abnormal alveolar lamellar body morphology "any structural anomaly of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0010909 pulmonary alveolar hemorrhage "bleeding into the small sac-like dilations of the distal airspace of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

 MP:0010993 decreased surfactant secretion "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Artm1Chc/Y,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Allelic Composition: Hspa5baffled/Hspa5baffled,Tg(Mbp-MAPT/lacZ)#aCaw/Tg(Mbp-MAPT/lacZ)#aCaw
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * FVB/N

Allelic Composition: Hspa5baffled/Hspa5baffled
Genetic Background: FVB.Cg-Hspa5baffled

 MP:0011093 complete embryonic lethality at implantation "death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5)" [MGI:csmith]
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Allelic Composition: Hiratm1Pjs/Hiratm1Pjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Pax3Sp-2H/Pax3+
Genetic Background: involves: 101 * C3H/He * CBA/Ca

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0012114 absent inner cell mass proliferation 
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Allelic Composition: Hiratm1Pjs/Hiratm1Pjs
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Glycam1tm1.1(KOMP)Vlcg/Glycam1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Glycam1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020715 Ern1 / Q9EQY0 / Serine/threonine-protein kinase/endoribonuclease IRE1 Serine/threonine-protein kinase Endoribonuclease / O75460* / endoplasmic reticulum to nucleus signaling 1*  / complex
 ENSMUSG00000026663 Atf6 / F6VAN0 / Cyclic AMP-dependent transcription factor ATF-6 alpha Processed cyclic AMP-dependent transcription factor ATF-6 alpha / P18850* / activating transcription factor 6*  / complex
 ENSMUSG00000031668 Eif2ak3 / eukaryotic translation initiation factor 2 alpha kinase 3 / Q9NZJ5*  / complex






 

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