ENSMUSG00000031668


Mus musculus

Features
Gene ID: ENSMUSG00000031668
  
Biological name :Eif2ak3
  
Synonyms : Eif2ak3 / eukaryotic translation initiation factor 2 alpha kinase 3
  
Possible biological names infered from orthology : Q9NZJ5
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 70844515
Gene end: 70905245
  
Corresponding Affymetrix probe sets: 10538939 (MoGene1.0st)   1430371_x_at (Mouse Genome 430 2.0 Array)   1449278_at (Mouse Genome 430 2.0 Array)   1453505_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123759
Ensembl peptide - ENSMUSP00000034093
NCBI entrez gene - 13666     See in Manteia.
MGI - MGI:1341830
RefSeq - XM_011241202
RefSeq - NM_001313918
RefSeq - NM_010121
RefSeq - XM_006505501
RefSeq Peptide - NP_001300847
RefSeq Peptide - NP_034251
swissprot - E9QQ30
swissprot - A0A0R4J1Y1
Ensembl - ENSMUSG00000031668
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2ak3ENSDARG00000062139Danio rerio
 EIF2AK3ENSGALG00000015958Gallus gallus
 Q9NZJ5ENSG00000172071Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9QZ05 / Eif2ak4 / eIF-2-alpha kinase GCN2 / Q9P2K8* / eukaryotic translation initiation factor 2 alpha kinase 4*ENSMUSG0000000510216
Q03963 / Eif2ak2 / Interferon-induced, double-stranded RNA-activated protein kinase / P19525* / eukaryotic translation initiation factor 2 alpha kinase 2*ENSMUSG0000002407914
Q9Z2R9 / Eif2ak1 / Eukaryotic translation initiation factor 2-alpha kinase 1 / Q9BQI3*ENSMUSG0000002961314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006983 ER overload response IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0032055 negative regulation of translation in response to stress IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0045943 positive regulation of transcription by RNA polymerase I IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0070417 cellular response to cold IEA
 biological_processGO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1990737 response to manganese-induced endoplasmic reticulum stress IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IEA


Pathways (from Reactome)
Pathway description
PERK regulates gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0000141 abnormal vertebral body morphology "malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
Show

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Tyos/Ccl2tm1Tyos
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif2ak3tm1Dron/Eif2ak3+,Tg(GFAP-tTA)110Pop/0,Tg(tetO-Ifng)184Pop/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster

 MP:0000953 abnormal oligodendrocyte morphology "anomalous structure, number or composition of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eif2ak3tm1Dron/Eif2ak3+,Tg(GFAP-tTA)110Pop/0,Tg(tetO-Ifng)184Pop/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Eif2ak3tm1Dron/Eif2ak3+,Tg(GFAP-tTA)110Pop/0,Tg(tetO-Ifng)184Pop/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Tyos/Ccl2tm1Tyos
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nos3tm1Unc/Nos3tm1Unc
Genetic Background: B6.129P2-Nos3tm1Unc/J

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0002791 steatorrhea "passage of large amounts of fat in the feces due to the inability to digest and absorb it" [J:75167]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif2ak3tm1Dron/Eif2ak3+,Tg(GFAP-tTA)110Pop/0,Tg(tetO-Ifng)184Pop/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster

 MP:0003335 exocrine pancreatic insufficiency "reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0003340 acute pancreas inflammation "early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into the pancreas; initiated by injury, infection, or local immune response " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

 MP:0005216 abnormal pancreatic alpha cell morphology "malformation of the cells of the pancreas that secrete glucagon" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0008027 abnormal spinal cord white matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak3tm1Dron/Eif2ak3+,Tg(GFAP-tTA)110Pop/0,Tg(tetO-Ifng)184Pop/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
Show

Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

 MP:0009164 exocrine pancreas atrophy "wasting of the acinar gland portion of the pancreas that secretes digestive enzymes resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak3tm1.1Drc/Eif2ak3tm1.1Drc,Tg(Ela1-cre)16Eps/0
Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * FVB)

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

 MP:0009178 absent pancreatic alpha cells "absence of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0010205 abnormal oligodendrocyte apoptosis "change in the timing or the number of oligodendrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak3tm1Dron/Eif2ak3+,Tg(GFAP-tTA)110Pop/0,Tg(tetO-Ifng)184Pop/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: CrygeElo/CrygeElo
Genetic Background: C3N.Cg-CrygeElo

Allelic Composition: Eif2ak3tm1Dron/Eif2ak3tm1Dron,Tg(GFAP-tTA)110Pop/0,Tg(tetO-Ifng)184Pop/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0013182 increased spinal cord apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Eif2ak3tm1Dron/Eif2ak3+,Tg(GFAP-tTA)110Pop/0,Tg(tetO-Ifng)184Pop/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * Swiss Webster

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

 MP:0030441 increased osteoblast apoptosis "increase in the number of osteoblasts undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Eif2ak3tm1Drc/Eif2ak3tm1Drc
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031668 Eif2ak3 / eukaryotic translation initiation factor 2 alpha kinase 3 / Q9NZJ5*  / complex / reaction
 ENSMUSG00000026864 Hspa5 / P20029 / heat shock protein 5 / P11021* / heat shock protein family A (Hsp70) member 5*  / complex
 ENSMUSG00000021116 Eif2s1 / Q6ZWX6 / Eukaryotic translation initiation factor 2 subunit 1 / P05198* / eukaryotic translation initiation factor 2 subunit alpha*  / reaction






 

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