ENSMUSG00000024079


Mus musculus

Features
Gene ID: ENSMUSG00000024079
  
Biological name :Eif2ak2
  
Synonyms : Eif2ak2 / Interferon-induced, double-stranded RNA-activated protein kinase / Q03963
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 2 alpha kinase 2 / P19525
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E3
Gene start: 78852564
Gene end: 78882573
  
Corresponding Affymetrix probe sets: 10452980 (MoGene1.0st)   1422005_at (Mouse Genome 430 2.0 Array)   1422006_at (Mouse Genome 430 2.0 Array)   1440866_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024884
NCBI entrez gene - 19106     See in Manteia.
MGI - MGI:1353449
RefSeq - NM_011163
RefSeq - XM_006523863
RefSeq Peptide - NP_035293
swissprot - Q03963
Ensembl - ENSMUSG00000024079
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2ak2ENSDARG00000068729Danio rerio
 pkzENSDARG00000052396Danio rerio
 EIF2AK2ENSGALG00000010560Gallus gallus
 P19525ENSG00000055332Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif2ak3 / eukaryotic translation initiation factor 2 alpha kinase 3 / Q9NZJ5*ENSMUSG0000003166830
Q9QZ05 / Eif2ak4 / eIF-2-alpha kinase GCN2 / Q9P2K8* / eukaryotic translation initiation factor 2 alpha kinase 4*ENSMUSG0000000510227
Q9Z2R9 / Eif2ak1 / Eukaryotic translation initiation factor 2-alpha kinase 1 / Q9BQI3*ENSMUSG0000002961321


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014720  Double-stranded RNA-binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR033366  Interferon-induced, double-stranded RNA-activated protein kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001819 positive regulation of cytokine production IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006412 translation IDA
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009615 response to virus ISS
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:0032722 positive regulation of chemokine production IMP
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IMP
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0035455 response to interferon-alpha IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:1900225 regulation of NLRP3 inflammasome complex assembly IMP
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1901532 regulation of hematopoietic progenitor cell differentiation IMP
 biological_processGO:1902033 regulation of hematopoietic stem cell proliferation IMP
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding ISO
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Psme3tm1Tchi/Psme3tm1Tchi
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
Genetic Background: involves: 129S4/SvJae

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Pgm1b-m1Ehs/Pgm1b-m1Ehs
Genetic Background: involves: DBA/2J

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Eif2ak2tm1Cwe/Eif2ak2tm1Cwe
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
Genetic Background: involves: 129S4/SvJae

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
Genetic Background: involves: 129S4/SvJae

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Tg(Drd1a-cre)AGsc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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