ENSMUSG00000029613


Mus musculus

Features
Gene ID: ENSMUSG00000029613
  
Biological name :Eif2ak1
  
Synonyms : Eif2ak1 / Eukaryotic translation initiation factor 2-alpha kinase 1 / Q9Z2R9
  
Possible biological names infered from orthology : Q9BQI3
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 143817788
Gene end: 143904251
  
Corresponding Affymetrix probe sets: 10527252 (MoGene1.0st)   1421900_at (Mouse Genome 430 2.0 Array)   1421901_at (Mouse Genome 430 2.0 Array)   1430696_at (Mouse Genome 430 2.0 Array)   1436006_at (Mouse Genome 430 2.0 Array)   1453902_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098056
NCBI entrez gene - 15467     See in Manteia.
MGI - MGI:1353448
RefSeq - NM_013557
RefSeq - XM_017320685
RefSeq Peptide - NP_038585
swissprot - Q9Z2R9
Ensembl - ENSMUSG00000029613
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2ak1ENSDARG00000093182Danio rerio
 EIF2AK1ENSGALG00000003391Gallus gallus
 Q9BQI3ENSG00000086232Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif2ak3 / eukaryotic translation initiation factor 2 alpha kinase 3 / Q9NZJ5*ENSMUSG0000003166826
Q9QZ05 / Eif2ak4 / eIF-2-alpha kinase GCN2 / Q9P2K8* / eukaryotic translation initiation factor 2 alpha kinase 4*ENSMUSG0000000510225
Q03963 / Eif2ak2 / Interferon-induced, double-stranded RNA-activated protein kinase / P19525* / eukaryotic translation initiation factor 2 alpha kinase 2*ENSMUSG0000002407918


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002526 acute inflammatory response IMP
 biological_processGO:0006417 regulation of translation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IEA
 biological_processGO:0010999 regulation of eIF2 alpha phosphorylation by heme IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030225 macrophage differentiation IMP
 biological_processGO:0046501 protoporphyrinogen IX metabolic process IGI
 biological_processGO:0046777 protein autophosphorylation IEP
 biological_processGO:0046984 regulation of hemoglobin biosynthetic process IGI
 biological_processGO:0046986 negative regulation of hemoglobin biosynthetic process IDA
 biological_processGO:0055072 iron ion homeostasis IMP
 biological_processGO:1990641 response to iron ion starvation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001589 abnormal mean corpuscular hemoglobin "anomalies in the average levels of hemoglobin contained in an erythrocyte" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011171 increased number of Heinz bodies "presence of intracellular inclusions usually attached to the red blood cell membrane, resulting from oxidative injury to and precipitation of hemoglobin in red blood cells" [http://www.dorlands.com/]
Show

Allelic Composition: Nr1h4tm1Kok/Nr1h4tm1Kok
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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