ENSMUSG00000005102


Mus musculus

Features
Gene ID: ENSMUSG00000005102
  
Biological name :Eif2ak4
  
Synonyms : Eif2ak4 / eIF-2-alpha kinase GCN2 / Q9QZ05
  
Possible biological names infered from orthology : eukaryotic translation initiation factor 2 alpha kinase 4 / Q9P2K8
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 118388618
Gene end: 118475234
  
Corresponding Affymetrix probe sets: 10474725 (MoGene1.0st)   1421389_a_at (Mouse Genome 430 2.0 Array)   1443235_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106493
Ensembl peptide - ENSMUSP00000106501
Ensembl peptide - ENSMUSP00000106498
Ensembl peptide - ENSMUSP00000106496
Ensembl peptide - ENSMUSP00000106494
Ensembl peptide - ENSMUSP00000005233
Ensembl peptide - ENSMUSP00000099586
NCBI entrez gene - 27103     See in Manteia.
MGI - MGI:1353427
RefSeq - XM_006499625
RefSeq - XM_017318909
RefSeq - XM_006499627
RefSeq - NM_001177806
RefSeq - NM_013719
RefSeq - XM_017318915
RefSeq - XM_006499626
RefSeq Peptide - NP_001171277
RefSeq Peptide - NP_038747
swissprot - Q9QZ05
swissprot - A2AUM2
swissprot - A2AUL9
swissprot - A2AUM0
swissprot - A2AUM1
Ensembl - ENSMUSG00000005102
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EIF2AK4ENSGALG00000009611Gallus gallus
 Q9P2K8ENSG00000128829Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif2ak3 / eukaryotic translation initiation factor 2 alpha kinase 3 / Q9NZJ5*ENSMUSG0000003166811
Q9Z2R9 / Eif2ak1 / Eukaryotic translation initiation factor 2-alpha kinase 1 / Q9BQI3*ENSMUSG000000296139
Q03963 / Eif2ak2 / Interferon-induced, double-stranded RNA-activated protein kinase / P19525* / eukaryotic translation initiation factor 2 alpha kinase 2*ENSMUSG000000240798


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR006575  RWD domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR016255  eIF-2-alpha kinase Gcn2
 IPR017441  Protein kinase, ATP binding site
 IPR024435  Histidyl tRNA synthetase-related domain
 IPR036621  Anticodon-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IDA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002286 T cell activation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002821 positive regulation of adaptive immune response IMP
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006446 regulation of translational initiation ISS
 biological_processGO:0006468 protein phosphorylation IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007612 learning IMP
 biological_processGO:0007616 long-term memory IMP
 biological_processGO:0009267 cellular response to starvation IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IGI
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IGI
 biological_processGO:0019081 viral translation IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IMP
 biological_processGO:0032057 negative regulation of translational initiation in response to stress IDA
 biological_processGO:0032792 negative regulation of CREB transcription factor activity IMP
 biological_processGO:0034198 cellular response to amino acid starvation IMP
 biological_processGO:0034644 cellular response to UV IDA
 biological_processGO:0034976 response to endoplasmic reticulum stress IGI
 biological_processGO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress ISO
 biological_processGO:0039520 induction by virus of host autophagy IMP
 biological_processGO:0043558 regulation of translational initiation in response to stress IDA
 biological_processGO:0044828 negative regulation by host of viral genome replication IDA
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045947 negative regulation of translational initiation IDA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060259 regulation of feeding behavior IMP
 biological_processGO:0060733 regulation of eIF2 alpha phosphorylation by amino acid starvation ISO
 biological_processGO:0070417 cellular response to cold ISS
 biological_processGO:0071264 positive regulation of translational initiation in response to starvation IMP
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IMP
 biological_processGO:1990138 neuron projection extension IMP
 biological_processGO:1990253 cellular response to leucine starvation IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0022626 cytosolic ribosome ISS
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0071074 eukaryotic initiation factor eIF2 binding IC


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndst2tm1Lkj/Ndst2tm1Lkj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Eif2ak4tm1.2Dron/Eif2ak4tm1.2Dron
Genetic Background: involves: 129S6/SvEvTac

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Stat3tm1Jbha/Stat3tm1Jbha,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0001934 increased litter size "greater numbers of live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Eif2ak4tm1Drc/Eif2ak4tm1Drc
Genetic Background: B6.129S6-Eif2ak4tm1Drc

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat3tm1Jbha/Stat3tm1Jbha,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Runx1tm1Spe/Runx1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprtm1.1Rll/Lepr+
Genetic Background: 129P3/J-Leprtm1.1Rll

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Leprtm1.1Rll/Lepr+
Genetic Background: 129P3/J-Leprtm1.1Rll

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1Spe/Runx1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Eif2ak4tm1Drc/Eif2ak4tm1Drc
Genetic Background: B6.129S6-Eif2ak4tm1Drc

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Eif2ak4tm1Drc/Eif2ak4tm1Drc
Genetic Background: B6.129S6-Eif2ak4tm1Drc

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Eif2ak4tm1Drc/Eif2ak4tm1Drc
Genetic Background: B6.129S6-Eif2ak4tm1Drc

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat3tm1Jbha/Stat3tm1Jbha,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eif2ak4tm1Drc/Eif2ak4tm1Drc
Genetic Background: B6.129S6-Eif2ak4tm1Drc

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcg5tm1Plo/Abcg5tm1Plo
Genetic Background: involves: 129P2/OlaHsd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Eif2ak4tm1Drc/Eif2ak4tm1Drc
Genetic Background: B6.129S6-Eif2ak4tm1Drc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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