ENSG00000086232


Homo sapiens

Features
Gene ID: ENSG00000086232
  
Biological name :EIF2AK1
  
Synonyms : EIF2AK1 / eukaryotic translation initiation factor 2 alpha kinase 1 / Q9BQI3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p22.1
Gene start: 6022244
Gene end: 6059230
  
Corresponding Affymetrix probe sets: 217735_s_at (Human Genome U133 Plus 2.0 Array)   217736_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000199389
Ensembl peptide - ENSP00000397590
Ensembl peptide - ENSP00000392734
Ensembl peptide - ENSP00000392459
NCBI entrez gene - 27102     See in Manteia.
OMIM - 613635
RefSeq - NM_001134335
RefSeq - NM_014413
RefSeq Peptide - NP_001127807
RefSeq Peptide - NP_055228
swissprot - Q9BQI3
swissprot - A0A024QZU1
swissprot - F8WCM0
swissprot - H7C033
swissprot - C9J7U7
Ensembl - ENSG00000086232
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2ak1ENSDARG00000093182Danio rerio
 EIF2AK1ENSGALG00000003391Gallus gallus
 Q9Z2R9ENSMUSG00000029613Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NZJ5 / EIF2AK3 / eukaryotic translation initiation factor 2 alpha kinase 3ENSG0000017207126
Q9P2K8 / EIF2AK4 / eukaryotic translation initiation factor 2 alpha kinase 4ENSG0000012882925
P19525 / EIF2AK2 / eukaryotic translation initiation factor 2 alpha kinase 2ENSG0000005533218


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IEA
 biological_processGO:0010999 regulation of eIF2 alpha phosphorylation by heme IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IEA
 biological_processGO:0030225 macrophage differentiation IEA
 biological_processGO:0045993 negative regulation of translational initiation by iron NAS
 biological_processGO:0046501 protoporphyrinogen IX metabolic process IEA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0046984 regulation of hemoglobin biosynthetic process IEA
 biological_processGO:0046986 negative regulation of hemoglobin biosynthetic process ISS
 biological_processGO:0055072 iron ion homeostasis IEA
 biological_processGO:1990641 response to iron ion starvation IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0020037 heme binding ISS
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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