ENSG00000055332


Homo sapiens

Features
Gene ID: ENSG00000055332
  
Biological name :EIF2AK2
  
Synonyms : EIF2AK2 / eukaryotic translation initiation factor 2 alpha kinase 2 / P19525
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p22.2
Gene start: 37099210
Gene end: 37157065
  
Corresponding Affymetrix probe sets: 204211_x_at (Human Genome U133 Plus 2.0 Array)   213294_at (Human Genome U133 Plus 2.0 Array)   238743_at (Human Genome U133 Plus 2.0 Array)   242898_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000233057
Ensembl peptide - ENSP00000378559
Ensembl peptide - ENSP00000385014
Ensembl peptide - ENSP00000393921
Ensembl peptide - ENSP00000374663
NCBI entrez gene - 5610     See in Manteia.
OMIM - 176871
RefSeq - XM_017004503
RefSeq - NM_001135651
RefSeq - NM_001135652
RefSeq - NM_002759
RefSeq - XM_011532987
RefSeq Peptide - NP_001129123
RefSeq Peptide - NP_001129124
RefSeq Peptide - NP_002750
swissprot - F8WBH4
swissprot - P19525
swissprot - C9JZT2
Ensembl - ENSG00000055332
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif2ak2ENSDARG00000068729Danio rerio
 pkzENSDARG00000052396Danio rerio
 EIF2AK2ENSGALG00000010560Gallus gallus
 Q03963ENSMUSG00000024079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9NZJ5 / EIF2AK3 / eukaryotic translation initiation factor 2 alpha kinase 3ENSG0000017207132
Q9P2K8 / EIF2AK4 / eukaryotic translation initiation factor 2 alpha kinase 4ENSG0000012882927
Q9BQI3 / EIF2AK1 / eukaryotic translation initiation factor 2 alpha kinase 1ENSG0000008623220


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014720  Double-stranded RNA-binding domain
 IPR017441  Protein kinase, ATP binding site
 IPR033366  Interferon-induced, double-stranded RNA-activated protein kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IMP
 biological_processGO:0001819 positive regulation of cytokine production ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0017148 negative regulation of translation IMP
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030683 evasion or tolerance by virus of host immune response TAS
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0032722 positive regulation of chemokine production ISS
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade ISS
 biological_processGO:0033689 negative regulation of osteoblast proliferation IMP
 biological_processGO:0034198 cellular response to amino acid starvation IMP
 biological_processGO:0035455 response to interferon-alpha IDA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046777 protein autophosphorylation IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:1900225 regulation of NLRP3 inflammasome complex assembly ISS
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling ISS
 biological_processGO:1901532 regulation of hematopoietic progenitor cell differentiation ISS
 biological_processGO:1902033 regulation of hematopoietic stem cell proliferation ISS
 biological_processGO:1902036 regulation of hematopoietic stem cell differentiation ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding TAS
 molecular_functionGO:0004672 protein kinase activity IMP
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IMP
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity TAS
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Inhibition of PKR


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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