ENSDARG00000052396


Danio rerio

Features
Gene ID: ENSDARG00000052396
  
Biological name :pkz
  
Synonyms : pkz / protein kinase containing Z-DNA binding domains
  
Possible biological names infered from orthology : EIF2AK2 / eukaryotic translation initiation factor 2 alpha kinase 2 / Interferon-induced, double-stranded RNA-activated protein kinase / P19525 / Q03963
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 50190664
Gene end: 50200348
  
Corresponding Affymetrix probe sets: Dr.18486.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000033668
Ensembl peptide - ENSDARP00000068719
NCBI entrez gene - 503703     See in Manteia.
swissprot - F1QXK7
swissprot - Q5NE14
ZFIN ID - ZDB-GENE-050301-2
Ensembl - ENSDARG00000052396
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 EIF2AK2ENSGALG00000010560Gallus gallus
 P19525ENSG00000055332Homo sapiens
 Q03963ENSMUSG00000024079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
eif2ak2 / eukaryotic translation initiation factor 2-alpha kinase 2 / P19525*ENSDARG0000006872928
eif2ak3 / eukaryotic translation initiation factor 2-alpha kinase 3 / Q9NZJ5*ENSDARG0000006213927
eif2ak1 / eukaryotic translation initiation factor 2-alpha kinase 1 / Q9BQI3* / Q9Z2R9*ENSDARG0000009318221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000607  Double-stranded RNA-specific adenosine deaminase (DRADA)
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011991  ArsR-like helix-turn-helix domain
 IPR017441  Protein kinase, ATP binding site
 IPR033366  Interferon-induced, double-stranded RNA-activated protein kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 biological_processGO:0045087 innate immune response IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003692 left-handed Z-DNA binding IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003726 double-stranded RNA adenosine deaminase activity IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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